(31 nodes) Mixed, incl. Preribosome, large subunit precursor, and Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (631 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (242 aa)
	nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae). (260 aa)
	wdr12	Ribosome biogenesis protein wdr12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (422 aa)
	noc3l	Nucleolar complex protein 3 homolog; Belongs to the CBF/MAK21 family. (800 aa)
	gnl3l	Guanine nucleotide-binding protein-like 3 (nucleolar)-like. (565 aa)
	pes	Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa)
	ddx18	RNA helicase. (653 aa)
	pa2g4a	Novel protein similar to human proliferation-associated 2G4 protein (PA2G4). (392 aa)
	nifk	MKI67 FHA domain-interacting nucleolar phosphoprotein; Plays an essential role in early embryonic development. (269 aa)
	rpf2	Ribosome production factor 2 homolog. (308 aa)
	rsl1d1	Ribosomal L1 domain-containing 1. (373 aa)
	nip7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. (180 aa)
	wdr74	WD repeat domain 74. (375 aa)
	noc2l	NOC2-like nucleolar-associated transcriptional repressor. (752 aa)
	rsl24d1	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). (161 aa)
	mak16	Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa)
	gnl3	Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa)
	rrs1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (346 aa)
	rpf1	Ribosome production factor 1; May be required for ribosome biogenesis. (352 aa)
	bop1	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (785 aa)
	nle1	Notchless homolog 1 (Drosophila). (476 aa)
	bxdc2	Brix domain-containing 2. (383 aa)
	nsun6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (459 aa)
	ftsj3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (838 aa)
	rrp1	Ribosomal RNA-processing 1. (673 aa)
	gnl2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (726 aa)
	sdad1	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (682 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (473 aa)
	ebna1bp2	EBNA1-binding protein 2. (308 aa)
	pum3	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (By similarity). Binds to double-stranded RNA or DNA without sequence specificity (By similarity). Involved in development of the eye and of primordial germ cells. (629 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bop1	bxdc2	ENSDARP00000120969	ENSDARP00000130248	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Brix domain-containing 2.	0.990
bop1	ddx18	ENSDARP00000120969	ENSDARP00000048752	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	RNA helicase.	0.987
bop1	ebna1bp2	ENSDARP00000120969	ENSDARP00000151663	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	EBNA1-binding protein 2.	0.987
bop1	ftsj3	ENSDARP00000120969	ENSDARP00000136961	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.989
bop1	gnl2	ENSDARP00000120969	ENSDARP00000140260	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.951
bop1	gnl3	ENSDARP00000120969	ENSDARP00000109517	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation.	0.980
bop1	gnl3l	ENSDARP00000120969	ENSDARP00000005405	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Guanine nucleotide-binding protein-like 3 (nucleolar)-like.	0.954
bop1	gtpbp4	ENSDARP00000120969	ENSDARP00000002061	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.982
bop1	mak16	ENSDARP00000120969	ENSDARP00000098580	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Protein MAK16 homolog; Plays an essential role in early embryonic development.	0.968
bop1	mrto4	ENSDARP00000120969	ENSDARP00000002982	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.990
bop1	nifk	ENSDARP00000120969	ENSDARP00000059548	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	MKI67 FHA domain-interacting nucleolar phosphoprotein; Plays an essential role in early embryonic development.	0.979
bop1	nip7	ENSDARP00000120969	ENSDARP00000076524	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.	0.981
bop1	nle1	ENSDARP00000120969	ENSDARP00000122687	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Notchless homolog 1 (Drosophila).	0.865
bop1	noc2l	ENSDARP00000120969	ENSDARP00000086095	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NOC2-like nucleolar-associated transcriptional repressor.	0.995
bop1	noc3l	ENSDARP00000120969	ENSDARP00000004350	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar complex protein 3 homolog; Belongs to the CBF/MAK21 family.	0.979
bop1	nop53	ENSDARP00000120969	ENSDARP00000145727	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.	0.674
bop1	nsa2	ENSDARP00000120969	ENSDARP00000003036	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NSA2 ribosome biogenesis homolog (S. cerevisiae).	0.985
bop1	nsun6	ENSDARP00000120969	ENSDARP00000131024	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.943
bop1	pa2g4a	ENSDARP00000120969	ENSDARP00000057822	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Novel protein similar to human proliferation-associated 2G4 protein (PA2G4).	0.823
bop1	pes	ENSDARP00000120969	ENSDARP00000026992	Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999

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