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traf3ip1 traf3ip1 b9d2 b9d2 arl3l2 arl3l2 tmem237b tmem237b ift22 ift22 unc119.1 unc119.1 zgc:112294 zgc:112294 ift57 ift57 b9d1 b9d1 invs invs ift81 ift81 poc1b poc1b pkd2 pkd2 ift74 ift74 ttc26 ttc26 ift88 ift88 pkd1a pkd1a unc119a unc119a ttc21b ttc21b arl6 arl6 flr flr bbs5 bbs5 bbs2 bbs2 ift172 ift172 tmem231 tmem231 nphp1 nphp1 unc119b unc119b ift52 ift52 nek8 nek8 arl2 arl2 mks1 mks1 bbs7 bbs7 ift46 ift46 zgc:158640 zgc:158640 wdr35 wdr35 arl13b arl13b cfap36 cfap36 arl3b arl3b sstr3 sstr3 C10H5orf30 C10H5orf30 alms1 alms1 cluap1 cluap1 nphp3 nphp3 pde6d pde6d bbs1 bbs1 tctn1 tctn1 bbs4 bbs4 armc9 armc9 rpgrip1l rpgrip1l tmem107l tmem107l nphp4 nphp4 arl2bp arl2bp TMEM216 TMEM216 ift140 ift140 rpusd1 rpusd1 tctn2 tctn2 ift80 ift80 tmem67 tmem67 bbip1 bbip1 asap1b asap1b rp2 rp2 ccdc28b ccdc28b znf423 znf423 bbs10 bbs10 tbc1d32 tbc1d32 ahi1 ahi1 cep290 cep290 unc119.2 unc119.2 pkd1b pkd1b opn6b opn6b arf4b arf4b ENSDARP00000131115 ENSDARP00000131115 ift27 ift27 iqcb1-2 iqcb1-2 iqcb1 iqcb1 inpp5e inpp5e cspp1 cspp1 tmem107 tmem107 lztfl1 lztfl1 ttc8 ttc8 cfap20 cfap20 fahd2a fahd2a ift20 ift20 wdr19 wdr19 cc2d2a cc2d2a bbs9 bbs9 tmem17 tmem17 arl3a arl3a bbs12 bbs12 sdccag8 sdccag8 ZNF423 ZNF423 ENSDARP00000157013 ENSDARP00000157013
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa)
b9d2B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. (175 aa)
arl3l2ADP ribosylation factor-like GTPase 3, like 2; Belongs to the small GTPase superfamily. Arf family. (187 aa)
tmem237bTransmembrane protein 237B; Component of the transition zone in primary cilia. Required for ciliogenesis. (413 aa)
ift22Intraflagellar transport protein 22 homolog; Belongs to the small GTPase superfamily. Rab family. (187 aa)
unc119.1Protein unc-119 homolog B; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in localization of proteins to the primary cilium membrane. Belongs to the PDE6D/unc-119 family. (243 aa)
zgc:112294Transmembrane protein 17A; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (222 aa)
ift57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. (407 aa)
b9d1B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (201 aa)
invsInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa)
ift81Intraflagellar transport 81 homolog. (675 aa)
poc1bPOC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa)
pkd2Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa)
ift74Intraflagellar transport 74. (583 aa)
ttc26Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. (557 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
pkd1aPolycystic kidney disease 1a. (4346 aa)
unc119aUnc-119 homolog a (C. elegans). (204 aa)
ttc21bTetratricopeptide repeat domain 21B. (1321 aa)
arl6ADP-ribosylation factor-like protein 6; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization. Belongs to the small GTPase superfamily. Arf family. (186 aa)
flrTetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. (651 aa)
bbs5Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa)
bbs2Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis. (715 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
tmem231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (309 aa)
nphp1Nephronophthisis 1. (667 aa)
unc119bProtein unc-119 homolog B. (264 aa)
ift52Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa)
nek8Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. (697 aa)
arl2ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
mks1MKS transition zone complex subunit 1. (559 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
ift46Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development; Belongs to the IFT46 family. (355 aa)
zgc:158640Zgc:158640. (134 aa)
wdr35WD repeat-containing protein 35. (1203 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
cfap36Cilia- and flagella-associated protein 36; Belongs to the CFAP36 family. (350 aa)
arl3bADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the ciliary membrane by releasing myristoylated protein from unc119 cargo adapters into the cilium (By similarity). (182 aa)
sstr3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (480 aa)
C10H5orf30Macrophage immunometabolism regulator; May play a role in immune regulation through regulation of the macrophage function (By similarity). Involved in the recruitment of macrophages in response to injury. May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization. (206 aa)
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
cluap1Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa)
nphp3Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. (1303 aa)
pde6dRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (150 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
tctn1Tectonic family member 1. (534 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
armc9LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis. (544 aa)
rpgrip1lRPGRIP1-like. (1256 aa)
tmem107lTransmembrane protein 107-like. (140 aa)
nphp4Si:dkey-202c5.1 protein. (189 aa)
arl2bpADP-ribosylation factor-like protein 2-binding protein; Plays a role as an effector of the ADP-ribosylation factor- like protein 2, ARL2; Belongs to the ARL2BP family. (203 aa)
TMEM216Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. (160 aa)
ift140Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa)
rpusd1RNA pseudouridylate synthase domain-containing protein 1; Belongs to the pseudouridine synthase RluA family. (293 aa)
tctn2Tectonic family member 2. (709 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
tmem67Transmembrane protein 67. (982 aa)
bbip1BBSome-interacting protein 1; Required for primary cilia assembly; Belongs to the BBIP10 family. (72 aa)
asap1bArfGAP with SH3 domain, ankyrin repeat and PH domain 1b. (1140 aa)
rp2Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa)
ccdc28bCoiled-coil domain-containing 28B. (213 aa)
znf423Zinc finger protein 423. (92 aa)
bbs10Bardet-Biedl syndrome 10. (151 aa)
tbc1d32Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling. (1298 aa)
ahi1Abelson helper integration site 1. (1193 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
unc119.2Unc-119 lipid-binding chaperone B homolog 2. (261 aa)
pkd1bPolycystic kidney disease 1b. (3827 aa)
opn6bOpsin 6, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (391 aa)
arf4bADP-ribosylation factor 4b; Belongs to the small GTPase superfamily. Arf family. (180 aa)
ENSDARP00000131115Si:zfos-169g10.2; Belongs to the G-protein coupled receptor 1 family. (429 aa)
ift27Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa)
iqcb1-2IQ motif-containing B1. (421 aa)
iqcb1IQ motif-containing B1. (595 aa)
inpp5eInositol polyphosphate-5-phosphatase E. (584 aa)
cspp1Centrosome and spindle pole-associated protein 1a. (1135 aa)
tmem107Transmembrane protein 107; May play a role in cilia formation and embryonic patterning. (135 aa)
lztfl1Leucine zipper transcription factor-like 1. (298 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
cfap20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. (192 aa)
fahd2aFumarylacetoacetate hydrolase domain-containing 2A. (289 aa)
ift20Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. (132 aa)
wdr19WD repeat domain 19. (1372 aa)
cc2d2aCoiled-coil and C2 domain-containing 2A. (1675 aa)
bbs9Bardet-Biedl syndrome 9. (842 aa)
tmem17Transmembrane protein 17B; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (191 aa)
arl3aADP ribosylation factor-like GTPase 3a; Belongs to the small GTPase superfamily. Arf family. (182 aa)
bbs12Bardet-Biedl syndrome 12. (763 aa)
sdccag8Serologically defined colon cancer antigen 8 homolog; Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (By similarity). (702 aa)
ZNF423Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity); Belongs to the kr [...] (1379 aa)
ENSDARP00000157013GMP_PDE_delta domain-containing protein. (74 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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