STRINGSTRING
ofd1 ofd1 ttbk2a ttbk2a cep135 cep135 stil stil plk4 plk4 cep68 cep68 ccsapb ccsapb crocc2 crocc2 cep63 cep63 cep76 cep76 sass6 sass6 cep131 cep131 F1R371_DANRE F1R371_DANRE wdr62 wdr62 neurl4 neurl4 cep70 cep70 cep120 cep120 ttbk2b ttbk2b cep170aa cep170aa cep104 cep104 ccdc120 ccdc120 cep89 cep89 sclt1 sclt1 mcph1 mcph1 pcnt pcnt nin nin c2cd3 c2cd3 cep97 cep97 ccdc14 ccdc14 talpid3 talpid3 cep192 cep192 cep128 cep128 aspm aspm pcm1 pcm1 lrrc45 lrrc45 cep83 cep83 cep72 cep72 spice1 spice1 ZNF335 ZNF335 cntln cntln cenpj cenpj
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ofd1Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family. (902 aa)
ttbk2aTau tubulin kinase 2a. (1193 aa)
cep135Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. (1164 aa)
stilSCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). (1263 aa)
plk4Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] (941 aa)
cep68Centrosomal protein 68. (650 aa)
ccsapbCentriole, cilia and spindle-associated protein; Plays a role in embryonic development, including proper left- right asymmetry formation. Also required for proper cilia beating. Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity). (263 aa)
crocc2Ciliary rootlet coiled-coil, rootletin family member 2. (1959 aa)
cep63Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). (689 aa)
cep76Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity). Belongs to the CEP76 family. (662 aa)
sass6Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). (627 aa)
cep131Centrosomal protein of 131 kDa; Cilium-specific protein required for the regulation of cilium/flagellum formation. Involved in centriole duplication (By similarity). May play a role in melanosome trafficking ; Belongs to the CEP131 family. (1111 aa)
F1R371_DANRESi:dkey-230p4.1. (2775 aa)
wdr62WD repeat domain 62. (1493 aa)
neurl4Neuralized E3 ubiquitin protein ligase 4. (1588 aa)
cep70Centrosomal protein 70. (609 aa)
cep120Centrosomal protein 120. (929 aa)
ttbk2bTau tubulin kinase 2b. (928 aa)
cep170aaCentrosomal protein 170Aa. (1479 aa)
cep104Centrosomal protein 104. (978 aa)
ccdc120Coiled-coil domain-containing 120. (615 aa)
cep89Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity). (711 aa)
sclt1Sodium channel and clathrin linker 1. (683 aa)
mcph1Microcephalin 1. (463 aa)
pcntPericentrin. (4245 aa)
ninNinein (GSK3B-interacting protein). (1954 aa)
c2cd3C2 domain-containing 3 centriole elongation regulator. (2114 aa)
cep97Centrosomal protein 97. (599 aa)
ccdc14Coiled-coil domain-containing 14. (886 aa)
talpid3Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa)
cep192Centrosomal protein 192. (2582 aa)
cep128Centrosomal protein 128. (533 aa)
aspmAbnormal spindle microtubule assembly. (3391 aa)
pcm1Pericentriolar material 1. (2018 aa)
lrrc45Leucine-rich repeat-containing 45. (674 aa)
cep83Centrosomal protein of 83 kDa; Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. (725 aa)
cep72Centrosomal protein of 72 kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Involved in centriole duplication (By similarity); Belongs to the CEP72 family. (532 aa)
spice1Spindle and centriole-associated protein 1. (724 aa)
ZNF335Si:ch211-269m15.3. (1534 aa)
cntlnCentlein, centrosomal protein. (1120 aa)
cenpjCentromere protein J. (1124 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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