STRINGSTRING
rab5b rab5b zgc:171927 zgc:171927 zgc:101559 zgc:101559 tbc1d19 tbc1d19 trappc6b trappc6b rab22a rab22a gdi2 gdi2 rab5ab rab5ab exoc3 exoc3 exoc3l2a exoc3l2a rabgef1l rabgef1l rab11al rab11al rabgef1 rabgef1 chm chm slc49a4 slc49a4 ehd1b ehd1b exoc4 exoc4 rab3il1 rab3il1 rilpl2 rilpl2 trappc4 trappc4 rab5aa rab5aa rab5c rab5c trappc5 trappc5 rab1ab rab1ab stxbp3 stxbp3 tbc1d20 tbc1d20 trappc13 trappc13 rab42a rab42a rgp1 rgp1 rps6ka3a rps6ka3a vps11 vps11 rab11fip1b rab11fip1b trappc11 trappc11 rab1ba rab1ba trappc1 trappc1 rab11a rab11a rab11ba rab11ba exoc1 exoc1 vps33b vps33b rab9a rab9a trappc3 trappc3 rab10 rab10 rab11fip1a rab11fip1a rab1aa rab1aa rab33ba rab33ba rab24 rab24 trappc8 trappc8 pim3 pim3 exoc2 exoc2 rab1bb rab1bb ccz1 ccz1 rab33a rab33a stxbp6l stxbp6l tnfaip2b tnfaip2b rab43 rab43 tbc1d25 tbc1d25 tbc1d9b tbc1d9b vps16 vps16 trappc12 trappc12 vps45 vps45 tgfbrap1 tgfbrap1 tbc1d22b tbc1d22b cracr2aa cracr2aa rabggtb rabggtb rab8b rab8b B8A5K8_DANRE B8A5K8_DANRE vps18 vps18 exoc3l1 exoc3l1 capn1b capn1b E7EYJ1_DANRE E7EYJ1_DANRE rabl6a rabl6a E7FDE3_DANRE E7FDE3_DANRE plekhm2 plekhm2 gapvd1 gapvd1 vps39 vps39 rbsn rbsn rabif rabif mon1a mon1a rabep2 rabep2 rabep1 rabep1 exoc7 exoc7 atg16l2-2 atg16l2-2 tnfaip2a tnfaip2a rab11fip4a rab11fip4a ankrd27 ankrd27 ptp4a2a ptp4a2a exoc8 exoc8 gdi1 gdi1 rab11bb rab11bb exoc6 exoc6 exoc3l4 exoc3l4 tbc1d4 tbc1d4 E9QDW7_DANRE E9QDW7_DANRE rabl3 rabl3 lca5 lca5 rabl6b rabl6b vps41 vps41 clk4b clk4b vps8 vps8 mon1ba mon1ba rab38b rab38b tbc1d8b tbc1d8b tbc1d14 tbc1d14 rab20 rab20 mical3b mical3b exoc5 exoc5 rab8a rab8a rab3gap2 rab3gap2 armc5 armc5 X1WCE1_DANRE X1WCE1_DANRE gareml gareml exoc3l2b exoc3l2b TRAPPC9 TRAPPC9 rab6a rab6a zgc:112334 zgc:112334 RAB19 RAB19 rab42b rab42b vipas39 vipas39 rab3gap1 rab3gap1 ENSDARP00000132178 ENSDARP00000132178 herc7 herc7 rab11fip2 rab11fip2 rab11fip4b rab11fip4b ptar1 ptar1 vps33a vps33a ENSDARP00000133373 ENSDARP00000133373 rab18b rab18b tbc1d8 tbc1d8 LOC570939 LOC570939 exoc6b exoc6b ankfy1 ankfy1 LOC100535428 LOC100535428 mical3a mical3a trappc2 trappc2 megf8-2 megf8-2 myo5b myo5b rab11fip5a rab11fip5a sfxn5a sfxn5a ENSDARP00000140484 ENSDARP00000140484 rab9b rab9b ENSDARP00000140736 ENSDARP00000140736 trappc10 trappc10 zgc:63863 zgc:63863 trappc9 trappc9 ehd1a ehd1a rab21 rab21 trappc2l trappc2l ENSDARP00000148800 ENSDARP00000148800 rab11fip3 rab11fip3 rab3ip rab3ip ENSDARP00000150109 ENSDARP00000150109 ENSDARP00000150161 ENSDARP00000150161 rab31 rab31 ENSDARP00000157027 ENSDARP00000157027 RIC1 RIC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rab5bRAB5B, member RAS oncogene family. (214 aa)
zgc:171927Zgc:171927. (210 aa)
zgc:101559Zgc:101559. (233 aa)
tbc1d19TBC1 domain family, member 19. (526 aa)
trappc6bTrafficking protein particle complex subunit 6b; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival. (157 aa)
rab22aRAB22A, member RAS oncogene family. (196 aa)
gdi2Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (448 aa)
rab5abRAB5A, member RAS oncogene family like. (216 aa)
exoc3Exocyst complex component 3. (748 aa)
exoc3l2aExocyst complex component 3-like 2a. (354 aa)
rabgef1lRAB guanine nucleotide exchange factor (GEF) 1,-like. (470 aa)
rab11alRAB11a, member RAS oncogene family,-like. (216 aa)
rabgef1RAB guanine nucleotide exchange factor (GEF) 1. (502 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
slc49a4Solute carrier family 49 member 4. (466 aa)
ehd1bEH-domain-containing 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (532 aa)
exoc4Exocyst complex component 4. (968 aa)
rab3il1RAB3A-interacting protein (rabin3)-like 1. (373 aa)
rilpl2RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport (By similarity); Belongs to the RILPL family. (195 aa)
trappc4Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (219 aa)
rab5aaRAB5A, member RAS oncogene family, a. (216 aa)
rab5cRAB5C, member RAS oncogene family. (221 aa)
trappc5Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (188 aa)
rab1abRAB1A, member RAS oncogene family b. (201 aa)
stxbp3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
tbc1d20TBC1 domain family, member 20. (397 aa)
trappc13Trafficking protein particle complex subunit 13. (412 aa)
rab42aRAB42, member RAS oncogene family a. (213 aa)
rgp1RGP1 retrograde golgi transport homolog (S. cerevisiae). (386 aa)
rps6ka3aRibosomal protein S6 kinase. (732 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
rab11fip1bRAB11 family-interacting protein 1 (class I) b. (169 aa)
trappc11Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. (1132 aa)
rab1baZRAB1B, member RAS oncogene family a. (201 aa)
trappc1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
rab11aNovel protein similar to vertebrate Ras family. (215 aa)
rab11baRAB11B, member RAS oncogene family, a. (218 aa)
exoc1Exocyst complex component 1. (892 aa)
vps33bVacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity (By similarity). Plays a role in bile duct development. ECO:0000250|UniProtKB:Q9H267, ; Belongs to the STXBP/unc-18/SEC1 [...] (617 aa)
rab9aRAB9A, member RAS oncogene family. (201 aa)
trappc3Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
rab10RAB10, member RAS oncogene family. (201 aa)
rab11fip1aRAB11 family-interacting protein 1 (class I) a. (456 aa)
rab1aaRAB1A, member RAS oncogene family a. (201 aa)
rab33baRAB33B, member RAS oncogene family a. (239 aa)
rab24RAB24, member RAS oncogene family. (202 aa)
trappc8Trafficking protein particle complex 8. (1478 aa)
pim3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (320 aa)
exoc2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (918 aa)
rab1bbRAB1B, member RAS oncogene family b. (201 aa)
ccz1Vacuolar fusion protein CCZ1 homolog. (480 aa)
rab33aRAB33A, member RAS oncogene family. (236 aa)
stxbp6lSyntaxin-binding protein 6 (amisyn),-like. (278 aa)
tnfaip2bTumor necrosis factor, alpha-induced protein 2b. (613 aa)
rab43RAB43, member RAS oncogene family. (208 aa)
tbc1d25TBC1 domain family, member 25. (863 aa)
tbc1d9bTBC1 domain family, member 9 (with GRAM domain). (1218 aa)
vps16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (835 aa)
trappc12Trafficking protein particle complex 12. (760 aa)
vps45Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (568 aa)
tgfbrap1Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. (863 aa)
tbc1d22bTBC1 domain family, member 22B. (459 aa)
cracr2aaCalcium release activated channel regulator 2A. (718 aa)
rabggtbGeranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (331 aa)
rab8bRAB8B, member RAS oncogene family. (209 aa)
B8A5K8_DANRESi:dkey-245p14.4. (183 aa)
vps18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and p [...] (974 aa)
exoc3l1Exocyst complex component 3-like protein; As part of the exocyst, may play a role in regulated exocytosis; Belongs to the SEC6 family. (780 aa)
capn1bCalpain 1, (mu/I) large subunit b; Belongs to the peptidase C2 family. (700 aa)
E7EYJ1_DANRESi:ch211-247i17.1. (118 aa)
rabl6aRAB, member RAS oncogene family-like 6a. (565 aa)
E7FDE3_DANRESi:ch211-266g18.9. (837 aa)
plekhm2Pleckstrin homology domain-containing, family M (with RUN domain) member 2. (994 aa)
gapvd1GTPase-activating protein and VPS9 domains 1. (512 aa)
vps39VPS39 subunit of HOPS complex. (875 aa)
rbsnRabenosyn, RAB effector. (715 aa)
rabifRAB-interacting factor. (132 aa)
mon1aMON1 secretory-trafficking family member A. (530 aa)
rabep2Rabaptin, RAB GTPase-binding effector protein 2. (483 aa)
rabep1Rabaptin, RAB GTPase-binding effector protein 1. (850 aa)
exoc7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (673 aa)
atg16l2-2ATG16 autophagy-related 16-like 2 (S. cerevisiae). (192 aa)
tnfaip2aTumor necrosis factor, alpha-induced protein 2a. (701 aa)
rab11fip4aRab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa)
ankrd27Ankyrin repeat domain 27 (VPS9 domain). (862 aa)
ptp4a2aProtein tyrosine phosphatase 4A2a. (168 aa)
exoc8Exocyst complex component 8. (684 aa)
gdi1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
rab11bbRAB11B, member RAS oncogene family, b. (218 aa)
exoc6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (801 aa)
exoc3l4Exocyst complex component 3-like 4. (787 aa)
tbc1d4TBC1 domain family, member 4. (1230 aa)
E9QDW7_DANRESi:dkey-261l7.2. (228 aa)
rabl3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (233 aa)
lca5Lebercilin LCA5. (754 aa)
rabl6bRAB, member RAS oncogene family-like 6b. (764 aa)
vps41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (855 aa)
clk4bCDC-like kinase 4b; Belongs to the protein kinase superfamily. (479 aa)
vps8VPS8 subunit of CORVET complex. (1412 aa)
mon1baMON1 secretory-trafficking family member Ba. (474 aa)
rab38bRAB38b, member of RAS oncogene family. (210 aa)
tbc1d8bTBC1 domain family member 8B; Involved in vesicular recycling, probably as a GTPase- activating protein for Rab family protein(s). (1108 aa)
tbc1d14TBC1 domain family, member 14. (711 aa)
rab20RAB20, member RAS oncogene family. (242 aa)
mical3bProtein-methionine sulfoxide oxidase mical3b; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1673 aa)
exoc5Exocyst complex component 5. (708 aa)
rab8aRAB8A, member RAS oncogene family. (207 aa)
rab3gap2RAB3 GTPase-activating protein subunit 2 (non-catalytic). (1345 aa)
armc5Armadillo repeat-containing 5. (1218 aa)
X1WCE1_DANRESi:ch211-116o3.5. (382 aa)
garemlGRB2-associated, regulator of MAPK1-like. (810 aa)
exoc3l2bExocyst complex component 3-like 2b. (861 aa)
TRAPPC9Si:dkey-218f9.10. (995 aa)
rab6aRAB6A, member RAS oncogene family. (208 aa)
zgc:112334Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (441 aa)
RAB19RAB19, member RAS oncogene family. (217 aa)
rab42bRAB42, member RAS oncogene family. (218 aa)
vipas39Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part vps33b. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical rab11a-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of vps33b. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indir [...] (505 aa)
rab3gap1Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (968 aa)
ENSDARP00000132178Uncharacterized protein. (115 aa)
herc7Hect domain and RLD 7. (424 aa)
rab11fip2RAB11 family-interacting protein 2 (class I). (478 aa)
rab11fip4bRab11 family-interacting protein 4B; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). (502 aa)
ptar1Protein prenyltransferase alpha subunit repeat-containing protein 1; Belongs to the protein prenyltransferase subunit alpha family. (426 aa)
vps33aVPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (599 aa)
ENSDARP00000133373Si:dkey-45k15.1. (632 aa)
rab18bRas-related protein Rab-18-B; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration; Belongs to the small GTPase superfamily. Rab family. (205 aa)
tbc1d8Uncharacterized protein. (1030 aa)
LOC570939Uncharacterized protein. (606 aa)
exoc6bExocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (802 aa)
ankfy1Ankyrin repeat and FYVE domain-containing 1. (1167 aa)
LOC100535428NACHT domain-containing protein. (1037 aa)
mical3aProtein-methionine sulfoxide oxidase mical3a; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1994 aa)
trappc2Trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (140 aa)
megf8-2Multiple EGF-like-domains 8. (173 aa)
myo5bMyosin VB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1839 aa)
rab11fip5aRAB11 family-interacting protein 5a (class I). (699 aa)
sfxn5aSidoreflexin. (347 aa)
ENSDARP00000140484Si:dkey-196h17.9. (546 aa)
rab9bRAB9B, member RAS oncogene family. (202 aa)
ENSDARP00000140736Uncharacterized protein. (195 aa)
trappc10Trafficking protein particle complex 10. (1228 aa)
zgc:63863Zgc:63863. (399 aa)
trappc9Trafficking protein particle complex 9. (133 aa)
ehd1aEH-domain-containing 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (533 aa)
rab21RAB21, member RAS oncogene family. (216 aa)
trappc2lTrafficking protein particle complex 2-like. (139 aa)
ENSDARP00000148800Uncharacterized protein. (169 aa)
rab11fip3Rab11 family-interacting protein 3. (1875 aa)
rab3ipRAB3A-interacting protein (rabin3). (436 aa)
ENSDARP00000150109Uncharacterized protein. (108 aa)
ENSDARP00000150161Si:ch211-117c9.2. (787 aa)
rab31Uncharacterized protein. (196 aa)
ENSDARP00000157027Uncharacterized protein. (99 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1321 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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