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vmp1 vmp1 uvrag uvrag chchd10 chchd10 smcr8b smcr8b C13H9orf72 C13H9orf72 rnf19a rnf19a chmp2bb chmp2bb cwf19l1 cwf19l1 scamp3 scamp3 ATG14 ATG14 nono nono pibf1 pibf1 sh3glb1a sh3glb1a atg4a atg4a rab39ba rab39ba nrbf2b nrbf2b nek1 nek1 tmem230a tmem230a gabarapl2 gabarapl2 tax1bp1b tax1bp1b atg3 atg3 map1lc3a map1lc3a sh3glb1b sh3glb1b gabarapa gabarapa atg4c atg4c atg13 atg13 stk35l stk35l fus fus chmp2ba chmp2ba tardbp tardbp glt8d1 glt8d1 wipi1 wipi1 zgc:92606 zgc:92606 tsc22d2 tsc22d2 Q5RIC1_DANRE Q5RIC1_DANRE atg101 atg101 atg9a atg9a dram1 dram1 gabarapb gabarapb smcr8a smcr8a MANEAL MANEAL pdik1l pdik1l dbr1 dbr1 dnaja3a dnaja3a atxn2 atxn2 pik3r4 pik3r4 ulk1a ulk1a atg16l2 atg16l2 pik3c3 pik3c3 atg12 atg12 rab39bb rab39bb hnrnpa3 hnrnpa3 vapb vapb als2a als2a rb1cc1 rb1cc1 ccdc61 ccdc61 becn1 becn1 sema4bb sema4bb puraa puraa map1lc3cl map1lc3cl qsox2 qsox2 map11 map11 nbr1b nbr1b mtss1lb mtss1lb atg4b atg4b wdr41 wdr41 stk35 stk35 rpain rpain cenpv cenpv ulk1b ulk1b rcn2 rcn2 adarb2 adarb2 hecw1b hecw1b E9QB44_DANRE E9QB44_DANRE arhgef28a arhgef28a sqstm1 sqstm1 matr3l1.2 matr3l1.2 znf106a znf106a wipi2 wipi2 atg9b atg9b nbr1a nbr1a ttll10 ttll10 tecpr2 tecpr2 epg5 epg5 atg5 atg5 arpp21 arpp21 fopnl fopnl wdr45b wdr45b atg4da atg4da ulk2 ulk2 atg2b atg2b atg16l1 atg16l1 cwf19l2 cwf19l2 map1lc3b map1lc3b stk40 stk40 map1lc3c map1lc3c ulk3 ulk3 plekhm1 plekhm1 ENSDARP00000132315 ENSDARP00000132315 ankib1a ankib1a oscp1a oscp1a ENSDARP00000132851 ENSDARP00000132851 ATG2A ATG2A atg7 atg7 OSCP1 OSCP1 atg10 atg10 atg4db atg4db wdfy3 wdfy3 ENSDARP00000148097 ENSDARP00000148097 rubcn rubcn wdr45 wdr45 LOC110438503 LOC110438503
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vmp1Vacuole membrane protein 1; Belongs to the VMP1 family. (406 aa)
uvragUV radiation resistance-associated gene. (664 aa)
chchd10Coiled-coil-helix-coiled-coil-helix domain-containing 10. (143 aa)
smcr8bGuanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa)
C13H9orf72Zgc:100846. (462 aa)
rnf19aRBR-type E3 ubiquitin transferase. (913 aa)
chmp2bbCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa)
cwf19l1CWF19-like protein 1. (544 aa)
scamp3Secretory carrier-associated membrane protein. (341 aa)
ATG14Zgc:113944. (517 aa)
nonoNon-POU domain-containing, octamer-binding. (441 aa)
pibf1Progesterone immunomodulatory-binding factor 1. (752 aa)
sh3glb1aSH3-domain GRB2-like endophilin B1a. (360 aa)
atg4aCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (375 aa)
rab39baRAB39B, member RAS oncogene family a. (213 aa)
nrbf2bNuclear receptor-binding factor 2b. (247 aa)
nek1NIMA-related kinase 1. (1200 aa)
tmem230aTransmembrane protein 230a. (120 aa)
gabarapl2GABA(A) receptor-associated protein-like 2. (117 aa)
tax1bp1bTax1-binding protein 1 homolog B; May have anti-apoptotic activity. (810 aa)
atg3Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] (317 aa)
map1lc3aMicrotubule-associated protein 1 light chain 3 alpha. (121 aa)
sh3glb1bSH3-domain GRB2-like endophilin B1b. (360 aa)
gabarapaGABA(A) receptor-associated protein a. (122 aa)
atg4cCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (463 aa)
atg13Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa)
stk35lSerine/threonine kinase 35,-like; Belongs to the protein kinase superfamily. (397 aa)
fusFUS RNA-binding protein. (541 aa)
chmp2baCharged multivesicular body protein 2Ba. (216 aa)
tardbpTAR DNA-binding protein. (412 aa)
glt8d1Glycosyltransferase 8 domain-containing protein 1. (365 aa)
wipi1WD repeat domain, phosphoinositide-interacting 1. (453 aa)
zgc:92606Zgc:92606. (117 aa)
tsc22d2KIAA0669-like protein. (556 aa)
Q5RIC1_DANRESi:ch211-63o20.7; Belongs to the protein kinase superfamily. (357 aa)
atg101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
dram1DNA-damage-regulated autophagy modulator 1. (240 aa)
gabarapbGABA(A) receptor-associated protein b. (152 aa)
smcr8aGuanine nucleotide exchange protein smcr8a; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (853 aa)
MANEALGlycoprotein endo-alpha-1,2-mannosidase-like protein. (442 aa)
pdik1lSerine/threonine-protein kinase pdik1l. (341 aa)
dbr1Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (568 aa)
dnaja3aDnaJ heat shock protein family (Hsp40) member A3a. (453 aa)
atxn2Ataxin 2. (1112 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1347 aa)
ulk1aUnc-51-like autophagy-activating kinase 1a. (927 aa)
atg16l2ATG16 autophagy-related 16-like 2 (S. cerevisiae). (302 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa)
rab39bbRAB39B, member RAS oncogene family b. (213 aa)
hnrnpa3Heterogeneous nuclear ribonucleoprotein A3. (339 aa)
vapbVAMP (vesicle-associated membrane protein)-associated protein B and C. (243 aa)
als2aAlsin Rho guanine nucleotide exchange factor ALS2 a. (1662 aa)
rb1cc1RB1-inducible coiled-coil 1. (1622 aa)
ccdc61Coiled-coil domain-containing protein 61. (525 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
sema4bbSemaphorin-4B; Belongs to the semaphorin family. (849 aa)
puraaPurine-rich element-binding protein Aa. (287 aa)
map1lc3clMicrotubule-associated protein 1 light chain 3 gamma,-like. (126 aa)
qsox2Sulfhydryl oxidase. (656 aa)
map11Microtubule-associated protein 11; Microtubule associated protein wich seems to play a role in spindle dynamics and cell division. Plays a role in brain cell proliferation. (595 aa)
nbr1bNBR1 autophagy cargo receptor b. (992 aa)
mtss1lbMTSS I-BAR domain-containing 2b. (712 aa)
atg4bCysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family. (394 aa)
wdr41WD repeat domain 41. (449 aa)
stk35Serine/threonine kinase 35; Belongs to the protein kinase superfamily. (406 aa)
rpainRPA-interacting protein. (225 aa)
cenpvCentromere protein V. (146 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
rcn2Reticulocalbin 2. (325 aa)
adarb2Adenosine deaminase RNA-specific B2 (inactive). (739 aa)
hecw1bHECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1b. (1552 aa)
E9QB44_DANRESi:ch1073-143l10.2. (228 aa)
arhgef28aRho guanine nucleotide exchange factor (GEF) 28a. (1753 aa)
sqstm1Sequestosome 1. (452 aa)
matr3l1.2Matrin 3-like 1.1. (1155 aa)
znf106aZinc finger protein 106a. (1636 aa)
wipi2WD repeat domain, phosphoinositide-interacting 2. (425 aa)
atg9bAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (806 aa)
nbr1aNBR1 autophagy cargo receptor a. (989 aa)
ttll10Tubulin tyrosine ligase-like family, member 10. (600 aa)
tecpr2Tectonin beta-propeller repeat-containing 2. (1358 aa)
epg5Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity). (2532 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
arpp21cAMP-regulated phosphoprotein, 21. (688 aa)
fopnlFgfr1op N-terminal-like. (146 aa)
wdr45bWD repeat domain phosphoinositide-interacting protein 3; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. In the cellular response to starvation, may also function in the inhibition of the mTORC1 signaling pathway. Belongs to the WD repeat SVP1 family. (344 aa)
atg4daCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (485 aa)
ulk2Unc-51-like autophagy-activating kinase 2. (1034 aa)
atg2bAutophagy-related 2B. (322 aa)
atg16l1ATG16 autophagy-related 16-like 1 (S. cerevisiae). (621 aa)
cwf19l2CWF19-like protein 2; Belongs to the CWF19 family. (961 aa)
map1lc3bMicrotubule-associated protein 1 light chain 3 beta. (122 aa)
stk40Serine/threonine kinase 40. (436 aa)
map1lc3cMicrotubule-associated protein 1 light chain 3 gamma. (128 aa)
ulk3Unc-51-like kinase 3. (407 aa)
plekhm1Pleckstrin homology domain-containing, family M (with RUN domain) member 1. (1058 aa)
ENSDARP00000132315Si:ch211-247j9.1. (622 aa)
ankib1aAnkyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. (1060 aa)
oscp1aOrganic solute carrier partner 1a. (391 aa)
ENSDARP00000132851Si:ch1073-266p11.2. (731 aa)
ATG2ASi:ch73-45o6.2. (2022 aa)
atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (711 aa)
OSCP1Organic solute carrier partner 1. (380 aa)
atg10ATG10 autophagy-related 10 homolog (S. cerevisiae). (224 aa)
atg4dbCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (411 aa)
wdfy3WD repeat and FYVE domain-containing 3. (3522 aa)
ENSDARP00000148097Uncharacterized protein. (115 aa)
rubcnRubicon autophagy regulator. (956 aa)
wdr45WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family. (358 aa)
LOC110438503Uncharacterized protein. (539 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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