STRINGSTRING
arhgef6 arhgef6 arhgdig arhgdig rnd3b rnd3b rhoab rhoab pak4 pak4 rhoj rhoj rhogb rhogb rhoq rhoq diras1a diras1a cdc42bpab cdc42bpab rhoaa rhoaa rhoua rhoua pak2b pak2b rasa1a rasa1a git1 git1 elmo3 elmo3 nck2b nck2b fgd6 fgd6 RTKN RTKN prex1 prex1 arhgap35b arhgap35b arhgap5 arhgap5 git2a git2a pkn1b pkn1b bcr bcr rhoh rhoh nck2a nck2a rhov rhov LOC100536197 LOC100536197 arhgef37 arhgef37 rac1a rac1a prex2 prex2 iqgap1 iqgap1 vav3b vav3b fmnl3 fmnl3 arhgef7b arhgef7b tiam1a tiam1a rnd3a rnd3a arhgef38 arhgef38 trip10a trip10a plekhg7 plekhg7 rac2 rac2 rac3b rac3b rac3a rac3a grk5l grk5l arhgef9b arhgef9b arhgap32b arhgap32b dock11 dock11 nck1b nck1b iqgap2 iqgap2 rock2a rock2a diaph3 diaph3 pkn1a pkn1a dock5 dock5 DOCK4 DOCK4 Rac1l Rac1l rhoga rhoga R4GED8_DANRE R4GED8_DANRE rac1l-2 rac1l-2 cdc42ep1a cdc42ep1a X1WBN8_DANRE X1WBN8_DANRE arhgap35a arhgap35a fgd5a fgd5a dock9b dock9b arhgef33 arhgef33 dock10 dock10 cdc42 cdc42 Vav3 Vav3 iqgap3 iqgap3 RAC1 RAC1 elmo1 elmo1 pak1 pak1 depdc1b depdc1b MYO9B MYO9B pak7 pak7 mcf2l2 mcf2l2 elmo2 elmo2 pak2a pak2a rock2b rock2b dock1 dock1 arhgef15 arhgef15 sowahca sowahca rock1 rock1 vav2 vav2 Dock2 Dock2 arhgef7a arhgef7a ENSDARP00000148010 ENSDARP00000148010 ENSDARP00000148259 ENSDARP00000148259 Dock2-like Dock2-like fmnl2b fmnl2b RASL10B RASL10B pkn2 pkn2 ENSDARP00000152387 ENSDARP00000152387 ENSDARP00000153262 ENSDARP00000153262 plekhg4 plekhg4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arhgef6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (766 aa)
arhgdigRho GDP dissociation inhibitor (GDI) gamma. (204 aa)
rnd3bRas-like protein Rnd3b. (224 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
pak4Non-specific serine/threonine protein kinase. (664 aa)
rhojRas homolog family member J. (226 aa)
rhogbRas homolog gene family, member Gb. (191 aa)
rhoqRas homolog gene family, member Q. (205 aa)
diras1aDIRAS family, GTP-binding RAS-like 1a. (195 aa)
cdc42bpabNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1716 aa)
rhoaaRho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
rhouaRas homolog gene family, member Ua. (254 aa)
pak2bNon-specific serine/threonine protein kinase. (537 aa)
rasa1aRAS p21 protein activator (GTPase-activating protein) 1a. (1010 aa)
git1G protein-coupled receptor kinase-interacting ArfGAP 1. (752 aa)
elmo3Engulfment and cell motility 3. (715 aa)
nck2bCytoplasmic protein. (380 aa)
fgd6FYVE, RhoGEF and PH domain-containing 6. (1315 aa)
RTKNSi:dkey-40c11.1. (630 aa)
prex1Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1622 aa)
arhgap35bRho GTPase-activating protein 35b. (1517 aa)
arhgap5Rho GTPase-activating protein 5. (1502 aa)
git2aG protein-coupled receptor kinase-interacting ArfGAP 2a. (750 aa)
pkn1bProtein kinase N1b. (909 aa)
bcrBCR activator of RhoGEF and GTPase. (1341 aa)
rhohRas homolog family member H. (195 aa)
nck2aCytoplasmic protein. (403 aa)
rhovNovel protein similar to vertebrate ras homolog gene family, member V (RHOV). (235 aa)
LOC100536197Non-specific serine/threonine protein kinase. (693 aa)
arhgef37Rho guanine nucleotide exchange factor (GEF) 37. (709 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
prex2Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1600 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
vav3bVav 3 guanine nucleotide exchange factor b. (826 aa)
fmnl3Formin-like protein 3; Required for developmental angiogenesis, but not for vasculogenesis; Belongs to the formin homology family. (1047 aa)
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b. (799 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
rnd3aRho family GTPase 3a. (243 aa)
arhgef38Rho guanine nucleotide exchange factor (GEF) 38. (771 aa)
trip10aCdc42-interacting protein 4 homolog; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Belongs to the FNBP1 family. (537 aa)
plekhg7Pleckstrin homology domain-containing, family G (with RhoGef domain) member 7. (769 aa)
rac2Rac family small GTPase 2. (219 aa)
rac3bRac family small GTPase 3b. (192 aa)
rac3aRas-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (192 aa)
grk5lG protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (575 aa)
arhgef9bCdc42 guanine nucleotide exchange factor (GEF) 9b. (514 aa)
arhgap32bRho GTPase-activating protein 32b. (1908 aa)
dock11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2067 aa)
nck1bCytoplasmic protein. (381 aa)
iqgap2IQ motif-containing GTPase-activating protein 2. (1680 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
diaph3Diaphanous-related formin 3. (1078 aa)
pkn1aProtein kinase N1a. (930 aa)
dock5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)
DOCK4Si:dkey-81e3.1; Belongs to the DOCK family. (1925 aa)
Rac1lSi:ch211-1f22.1. (192 aa)
rhogaRas homolog family member Ga. (191 aa)
R4GED8_DANRESi:ch211-1f22.2. (190 aa)
rac1l-2Rac family small GTPase 1,-like. (229 aa)
cdc42ep1aCDC42 effector protein (Rho GTPase-binding) 1a. (351 aa)
X1WBN8_DANRESi:dkey-56f14.7. (254 aa)
arhgap35aRho GTPase-activating protein 35a. (1536 aa)
fgd5aFYVE, RhoGEF and PH domain-containing 5a. (1473 aa)
dock9bDedicator of cytokinesis 9b; Belongs to the DOCK family. (2075 aa)
arhgef33Rho guanine nucleotide exchange factor (GEF) 33. (707 aa)
dock10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2185 aa)
cdc42Cell division cycle 42. (191 aa)
Vav3Si:ch73-383g2.1. (253 aa)
iqgap3IQ motif-containing GTPase-activating protein 3. (1639 aa)
RAC1Rac family small GTPase 1. (166 aa)
elmo1Engulfment and Cell motility 1 (Ced-12 homolog, C. elegans). (726 aa)
pak1Non-specific serine/threonine protein kinase. (587 aa)
depdc1bRho-GAP domain-containing protein. (405 aa)
MYO9BSi:zfos-588f8.1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2085 aa)
pak7P21 protein (Cdc42/Rac)-activated kinase 7. (645 aa)
mcf2l2MCF.2 cell line-derived-transforming sequence-like 2. (1249 aa)
elmo2Engulfment and cell motility 2. (675 aa)
pak2aNon-specific serine/threonine protein kinase. (518 aa)
rock2bRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
dock1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1840 aa)
arhgef15Rho guanine nucleotide exchange factor (GEF) 15. (917 aa)
sowahcaSosondowah ankyrin repeat domain family Ca. (505 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
vav2Vav 2 guanine nucleotide exchange factor. (875 aa)
Dock2DHR-2 domain-containing protein; Belongs to the DOCK family. (369 aa)
arhgef7aRho guanine nucleotide exchange factor (GEF) 7a. (859 aa)
ENSDARP00000148010DOCK_N domain-containing protein. (164 aa)
ENSDARP00000148259DHR-1 domain-containing protein; Belongs to the DOCK family. (83 aa)
Dock2-likeUncharacterized protein. (253 aa)
fmnl2bFormin-like 2b. (1129 aa)
RASL10BRAS like family 10 member B. (160 aa)
pkn2Serine/threonine-protein kinase N2. (1005 aa)
ENSDARP00000152387DHR-2 domain-containing protein; Belongs to the DOCK family. (140 aa)
ENSDARP00000153262Uncharacterized protein. (69 aa)
plekhg4Pleckstrin homology domain-containing, family G (with RhoGef domain) member 4. (2656 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.