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map2k1 map2k1 mark3b mark3b A3KQ53_DANRE A3KQ53_DANRE prmt1 prmt1 ralab ralab rps6kb1a rps6kb1a rras rras map2k2a map2k2a hrasb hrasb rnf144aa rnf144aa pdpk1b pdpk1b ywhae2 ywhae2 sgk2b sgk2b ywhaqb ywhaqb zgc:55558 zgc:55558 akt2 akt2 sgk1 sgk1 ywhae1 ywhae1 tsc1a tsc1a foxo3a foxo3a tbc1d7 tbc1d7 ywhaz ywhaz rasd3 rasd3 braf braf nos2b nos2b cdkn1ba cdkn1ba rap1aa rap1aa zgc:110699 zgc:110699 rras2 rras2 nras nras setd7 setd7 rhebl1 rhebl1 ralba ralba shoc2 shoc2 ywhaqa ywhaqa foxo3b foxo3b ralaa ralaa foxo4 foxo4 rap1gap rap1gap RASSF5 RASSF5 rps6kb1b rps6kb1b raf1b raf1b GARNL3 GARNL3 foxo1b foxo1b rasl10a rasl10a rasgrp2 rasgrp2 shank3a shank3a sirt1 sirt1 ftr83 ftr83 ralgps1 ralgps1 prr5a prr5a rap1gap2a rap1gap2a pdpk1a pdpk1a F1QYY8_DANRE F1QYY8_DANRE mapk3 mapk3 ralbp1 ralbp1 LOC100332969 LOC100332969 rap1gap2b rap1gap2b ywhabb ywhabb mtor mtor nos2a nos2a rheb rheb rap1ab rap1ab mapkap1 mapkap1 akt3b akt3b rap1b rap1b shank3b shank3b F1QZR0_DANRE F1QZR0_DANRE l3mbtl1-2 l3mbtl1-2 syngap1a syngap1a apbb1ip apbb1ip ksr1a ksr1a mlst8 mlst8 araf araf rictorb rictorb RALGDS RALGDS tsc1b tsc1b diras1b diras1b nf1b nf1b prkcg prkcg B8JKT4_DANRE B8JKT4_DANRE deptor deptor MRAS MRAS mlf1 mlf1 spred2a spred2a ddit4 ddit4 akt1s1 akt1s1 nf1a nf1a X1WFB5_DANRE X1WFB5_DANRE tfe3b tfe3b ksr1b ksr1b raf1a-2 raf1a-2 raf1a raf1a akt1 akt1 tsc2 tsc2 rptor rptor foxo1a foxo1a rictora rictora zgc:171558 zgc:171558 nos1 nos1 tfe3a tfe3a foxo6a foxo6a akt3a akt3a dlgap1b dlgap1b akt2l akt2l rragcb rragcb hrasa hrasa shank2a shank2a LOC101885386 LOC101885386 Prr5b Prr5b dusp26 dusp26 ENSDARP00000153406 ENSDARP00000153406 ENSDARP00000153499 ENSDARP00000153499 ralbb ralbb rapgef6 rapgef6 lratb.1-2 lratb.1-2 rapgef5a rapgef5a
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
mark3bNon-specific serine/threonine protein kinase. (754 aa)
A3KQ53_DANRENon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (423 aa)
prmt1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (348 aa)
ralabV-ral simian leukemia viral oncogene homolog Ab (ras-related). (202 aa)
rps6kb1aRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (506 aa)
rrasRelated RAS viral (R-ras) oncogene homolog. (196 aa)
map2k2aMitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
hrasb-Ha-ras Harvey rat sarcoma viral oncogene homolog, like. (189 aa)
rnf144aaProbable E3 ubiquitin-protein ligase RNF144A-A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (293 aa)
pdpk1b3-phosphoinositide-dependent protein kinase 1b. (537 aa)
ywhae2Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (255 aa)
sgk2bSerum/glucocorticoid-regulated kinase 2b; Belongs to the protein kinase superfamily. (404 aa)
ywhaqbTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa)
zgc:55558Zgc:55558 protein. (187 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
sgk1Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (433 aa)
ywhae1Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
foxo3aForkhead box O3A. (643 aa)
tbc1d7TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). (294 aa)
ywhazTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (244 aa)
rasd3RASD family member 3. (211 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (817 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
cdkn1baCyclin-dependent kinase inhibitor 1Ba. (187 aa)
rap1aaRAP1A, member of RAS oncogene family a. (185 aa)
zgc:110699Zgc:110699 protein. (211 aa)
rras2Related RAS viral (R-ras) oncogene homolog 2. (202 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
setd7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. (373 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
ralbaV-ral simian leukemia viral oncogene homolog Ba (ras-related). (207 aa)
shoc2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity). (561 aa)
ywhaqaTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (245 aa)
foxo3bForkhead box O3b. (651 aa)
ralaaV-ral simian leukemia viral oncogene homolog Aa (ras-related). (206 aa)
foxo4Forkhead box O4. (626 aa)
rap1gapRAP1 GTPase-activating protein. (695 aa)
RASSF5Si:dkey-85p17.3. (482 aa)
rps6kb1bRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
raf1bRaf-1 proto-oncogene, serine/threonine kinase b. (629 aa)
GARNL3GTPase-activating Rap/Ran-GAP domain-like protein 3; Belongs to the GARNL3 family. (1015 aa)
foxo1bForkhead box protein O1-B; Transcriptional regulator of cell cycle arrest required for cellular stress responses. (629 aa)
rasl10aRAS-like, family 10, member A. (203 aa)
rasgrp2RAS guanyl-releasing protein 2 (calcium and DAG-regulated). (579 aa)
shank3aSH3 and multiple ankyrin repeat domains 3a. (1509 aa)
sirt1Sirtuin 1. (710 aa)
ftr83FinTRIM family, member 83. (420 aa)
ralgps1Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor. May be involved in cytoskeletal organization. (581 aa)
prr5aProline-rich 5a (renal). (453 aa)
rap1gap2aRAP1 GTPase-activating protein 2a. (472 aa)
pdpk1a3-phosphoinositide-dependent protein kinase 1a. (536 aa)
F1QYY8_DANRESi:dkeyp-97e7.9. (393 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
ralbp1RalA-binding protein 1. (665 aa)
LOC100332969RAP2A, member of RAS oncogene family a. (183 aa)
rap1gap2bRAP1 GTPase-activating protein 2b. (696 aa)
ywhabb14-3-3 protein beta/alpha-B; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (242 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
rap1abRAP1A, member of RAS oncogene family b. (185 aa)
mapkap1MAPK-associated protein 1. (527 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
rap1bRas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
shank3bSH3 and multiple ankyrin repeat domains 3b. (1631 aa)
F1QZR0_DANRESi:dkey-21o19.2. (159 aa)
l3mbtl1-2L3MBTL histone methyl-lysine-binding protein 1. (200 aa)
syngap1aSynaptic Ras GTPase-activating protein 1a. (1290 aa)
apbb1ipAmyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family. (645 aa)
ksr1aKinase suppressor of ras 1a. (1025 aa)
mlst8Target of rapamycin complex subunit lst8. (326 aa)
arafA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
rictorbRPTOR-independent companion of MTOR, complex 2b. (1698 aa)
RALGDSSi:ch211-251j10.3. (813 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
diras1bDIRAS family, GTP-binding RAS-like 1b. (198 aa)
nf1bNeurofibromin 1b. (2759 aa)
prkcgProtein kinase C, gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (654 aa)
B8JKT4_DANRESi:ch73-263f13.1. (106 aa)
deptorDEP domain-containing MTOR-interacting protein. (407 aa)
MRASSi:ch73-116o1.2. (208 aa)
mlf1Myeloid leukemia factor 1. (255 aa)
spred2aSprouty-related EVH1 domain-containing 2a. (421 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa)
akt1s1AKT1 substrate 1 (proline-rich). (354 aa)
nf1aNeurofibromin 1a. (2759 aa)
X1WFB5_DANRESi:ch211-147k10.5. (341 aa)
tfe3bTranscription factor-binding to IGHM enhancer 3b. (451 aa)
ksr1bKinase suppressor of ras 1b. (940 aa)
raf1a-2Raf-1 proto-oncogene, serine/threonine kinase a. (186 aa)
raf1aRaf-1 proto-oncogene, serine/threonine kinase a. (654 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
tsc2TSC complex subunit 2. (1674 aa)
rptorRegulatory-associated protein of MTOR, complex 1. (1363 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
rictoraRPTOR-independent companion of MTOR, complex 2 a. (1686 aa)
zgc:171558Zgc:171558. (1005 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
tfe3aTranscription factor-binding to IGHM enhancer 3a. (539 aa)
foxo6aForkhead box O6 a. (594 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
dlgap1bDiscs, large (Drosophila) homolog-associated protein 1b. (1001 aa)
akt2lV-akt murine thymoma viral oncogene homolog 2,-like. (478 aa)
rragcbRas-related GTP-binding Cb. (392 aa)
hrasaHRas proto-oncogene, GTPase a. (189 aa)
shank2aSH3 and multiple ankyrin repeat domains 2a. (1306 aa)
LOC101885386Uncharacterized protein. (224 aa)
Prr5bUncharacterized protein. (122 aa)
dusp26Uncharacterized protein. (594 aa)
ENSDARP00000153406DUF3384 domain-containing protein. (162 aa)
ENSDARP00000153499Uncharacterized protein. (102 aa)
ralbbV-ral simian leukemia viral oncogene homolog Bb (ras-related). (100 aa)
rapgef6Rap guanine nucleotide exchange factor (GEF) 6. (1261 aa)
lratb.1-2Si:ch73-132f6.5. (679 aa)
rapgef5aRap guanine nucleotide exchange factor (GEF) 5a. (588 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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