STRINGSTRING
A3KQ53_DANRE A3KQ53_DANRE prmt1 prmt1 rps6kb1a rps6kb1a pdpk1b pdpk1b sgk2b sgk2b akt2 akt2 sgk1 sgk1 tsc1a tsc1a foxo3a foxo3a tbc1d7 tbc1d7 nos2b nos2b cdkn1ba cdkn1ba setd7 setd7 rhebl1 rhebl1 foxo3b foxo3b foxo4 foxo4 rps6kb1b rps6kb1b foxo1b foxo1b sirt1 sirt1 prr5a prr5a pdpk1a pdpk1a F1QYY8_DANRE F1QYY8_DANRE mtor mtor nos2a nos2a rheb rheb mapkap1 mapkap1 akt3b akt3b l3mbtl1-2 l3mbtl1-2 mlst8 mlst8 rictorb rictorb tsc1b tsc1b deptor deptor ddit4 ddit4 akt1s1 akt1s1 akt1 akt1 tsc2 tsc2 rptor rptor foxo1a foxo1a rictora rictora nos1 nos1 foxo6a foxo6a akt3a akt3a akt2l akt2l rragcb rragcb ENSDARP00000153406 ENSDARP00000153406
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A3KQ53_DANRENon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (423 aa)
prmt1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (348 aa)
rps6kb1aRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (506 aa)
pdpk1b3-phosphoinositide-dependent protein kinase 1b. (537 aa)
sgk2bSerum/glucocorticoid-regulated kinase 2b; Belongs to the protein kinase superfamily. (404 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
sgk1Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (433 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
foxo3aForkhead box O3A. (643 aa)
tbc1d7TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). (294 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
cdkn1baCyclin-dependent kinase inhibitor 1Ba. (187 aa)
setd7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. (373 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
foxo3bForkhead box O3b. (651 aa)
foxo4Forkhead box O4. (626 aa)
rps6kb1bRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
foxo1bForkhead box protein O1-B; Transcriptional regulator of cell cycle arrest required for cellular stress responses. (629 aa)
sirt1Sirtuin 1. (710 aa)
prr5aProline-rich 5a (renal). (453 aa)
pdpk1a3-phosphoinositide-dependent protein kinase 1a. (536 aa)
F1QYY8_DANRESi:dkeyp-97e7.9. (393 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
mapkap1MAPK-associated protein 1. (527 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
l3mbtl1-2L3MBTL histone methyl-lysine-binding protein 1. (200 aa)
mlst8Target of rapamycin complex subunit lst8. (326 aa)
rictorbRPTOR-independent companion of MTOR, complex 2b. (1698 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
deptorDEP domain-containing MTOR-interacting protein. (407 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa)
akt1s1AKT1 substrate 1 (proline-rich). (354 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
tsc2TSC complex subunit 2. (1674 aa)
rptorRegulatory-associated protein of MTOR, complex 1. (1363 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
rictoraRPTOR-independent companion of MTOR, complex 2 a. (1686 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
foxo6aForkhead box O6 a. (594 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
akt2lV-akt murine thymoma viral oncogene homolog 2,-like. (478 aa)
rragcbRas-related GTP-binding Cb. (392 aa)
ENSDARP00000153406DUF3384 domain-containing protein. (162 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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