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atf6 atf6 ern1 ern1 creb3l3l creb3l3l eif2s1a eif2s1a trib3 trib3 map3k5 map3k5 atf4b atf4b creb1a creb1a ddit3 ddit3 creb5b creb5b dab2ipb dab2ipb xbp1 xbp1 ppp5c ppp5c LOC100334396 LOC100334396 creb3l3b creb3l3b creb3l3a creb3l3a eif2ak1 eif2ak1 dab2ipa dab2ipa ern2 ern2 eif2ak3 eif2ak3 creb3l2 creb3l2 eif2a eif2a creb5a creb5a cremb cremb traf2b traf2b atf4a atf4a ENSDARP00000146561 ENSDARP00000146561
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atf6Activating transcription factor 6. (653 aa)
ern1Endoplasmic reticulum to nucleus-signaling 1. (1031 aa)
creb3l3lcAMP-responsive element-binding protein 3-like 3 like. (503 aa)
eif2s1aEukaryotic translation initiation factor 2, subunit 1 alpha, like. (315 aa)
trib3Tribbles pseudokinase 3. (348 aa)
map3k5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
atf4bActivating transcription factor 4b. (425 aa)
creb1acAMP-responsive element-binding protein 1a. (318 aa)
ddit3DNA-damage-inducible transcript 3. (242 aa)
creb5bCyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (480 aa)
dab2ipbDAB2-interacting protein b. (1178 aa)
xbp1Transcription factor Treb5. (263 aa)
ppp5cSerine/threonine-protein phosphatase. (489 aa)
LOC100334396Uncharacterized protein. (415 aa)
creb3l3bCyclic AMP-responsive element-binding protein 3-like protein 3-B. (388 aa)
creb3l3aProcessed cyclic AMP-responsive element-binding protein 3-like protein 3-B; Transcriptional activator. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with atf6 (By similarity). (460 aa)
eif2ak1Eukaryotic translation initiation factor 2-alpha kinase 1. (668 aa)
dab2ipaDAB2-interacting protein a. (1147 aa)
ern2Endoplasmic reticulum to nucleus-signaling 2. (927 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
creb3l2Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (519 aa)
eif2aEukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (580 aa)
creb5aCyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (450 aa)
crembcAMP-responsive element modulator b. (108 aa)
traf2bTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
atf4aCyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa)
ENSDARP00000146561Si:ch211-1i11.3. (1356 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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