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hsp90ab1 hsp90ab1 hsp90aa1.1 hsp90aa1.1 hsp90aa1.2 hsp90aa1.2 fkbp5 fkbp5 ptges3a ptges3a nr3c1 nr3c1 ar ar stip1 stip1 ppid ppid hsp70.1 hsp70.1 ahsa1a ahsa1a fkbp4 fkbp4 nr3c2 nr3c2 cdc37 cdc37 LOC103910107 LOC103910107 sugt1 sugt1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hsp90ab1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (725 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
hsp90aa1.2Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (734 aa)
fkbp5Peptidylprolyl isomerase. (453 aa)
ptges3aProstaglandin E synthase 3a (cytosolic). (159 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
arAndrogen receptor. (868 aa)
stip1Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). (542 aa)
ppidPeptidylprolyl isomerase D (Cyclophilin D). (371 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
ahsa1aAHA1, activator of heat shock protein ATPase homolog 1a. (316 aa)
fkbp4Peptidylprolyl isomerase. (450 aa)
nr3c2Nuclear receptor subfamily 3, group C, member 2. (970 aa)
cdc37Cell division cycle 37 homolog (S. cerevisiae). (364 aa)
LOC103910107NACHT domain-containing protein. (847 aa)
sugt1SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (322 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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