STRINGSTRING
tbx16 tbx16 cdh2 cdh2 prdm1a prdm1a lft1 lft1 foxa2 foxa2 twist3 twist3 vim vim nkx2.5 nkx2.5 shox2 shox2 dlx3b dlx3b noto noto hand2 hand2 tbx3a tbx3a gata5 gata5 tbx20 tbx20 six1b six1b wt1a wt1a tbx5a tbx5a pax3a pax3a csrnp1a csrnp1a tdgf1 tdgf1 twist1a twist1a zeb1b zeb1b pitx2 pitx2 dand5 dand5 tcf21 tcf21 sox8b sox8b klf17 klf17 snai2 snai2 lft2 lft2 sall4 sall4 pou5f3 pou5f3 snai1b snai1b ndr1 ndr1 gsc gsc mef2ca mef2ca tbx18 tbx18 sox2 sox2 klf4 klf4 csrnp1b csrnp1b sox10 sox10 myca myca nanog nanog twist2 twist2 foxa foxa zic1 zic1 foxd3 foxd3 mixl1 mixl1 snai1a snai1a pcdh8 pcdh8 F1Q5G8_DANRE F1Q5G8_DANRE spaw spaw eya1 eya1 tfcp2l1 tfcp2l1 hcn4 hcn4 lmcd1 lmcd1 foxi1 foxi1 gata4 gata4 sox17 sox17 cdh1 cdh1 gata6 gata6 LIN28A LIN28A sox32 sox32 ctnnb1 ctnnb1 ndr2 ndr2 tbxta tbxta zeb2a zeb2a esrrb esrrb msx1a msx1a tbxtb tbxtb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx16T-box transcription factor 16. (470 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
twist3Twist3. (199 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
nkx2.5NK2 homeobox 5. (314 aa)
shox2Short stature homeobox 2. (299 aa)
dlx3bHomeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa)
notoNotochord homeobox. (241 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
tbx3aT-box transcription factor 3a. (689 aa)
gata5Transcription factor gata5. (383 aa)
tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
wt1aWT1 transcription factor a. (419 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
pax3aTranscription factor PAX3. (509 aa)
csrnp1aCysteine-serine-rich nuclear protein 1a. (514 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
twist1aTwist family bHLH transcription factor 1a. (171 aa)
zeb1bZinc finger E-box-binding homeobox 1b. (1078 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
dand5DAN domain family, member 5. (243 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
sox8bSRY-box transcription factor 8b. (356 aa)
klf17Kruppel-like factor 17. (409 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
lft2Left-right determination factor. (362 aa)
sall4Spalt-like transcription factor 4. (1091 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
snai1bSnail family zinc finger 1b. (256 aa)
ndr1Nodal-related 1. (392 aa)
gscHomeobox protein goosecoid. (240 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
tbx18T-box transcription factor 18. (554 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
klf4Kruppel-like factor 4. (340 aa)
csrnp1bCysteine-serine-rich nuclear protein 1b. (566 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
nanogOvary-expressed homeobox protein. (384 aa)
twist2Twist2. (163 aa)
foxaForkhead box A sequence. (355 aa)
zic1ZIC family member 1 (Odd-paired homolog, Drosophila). (442 aa)
foxd3Forkhead box D3. (371 aa)
mixl1Mix paired-like homeobox. (327 aa)
snai1aSnail family zinc finger 1a. (260 aa)
pcdh8Protocadherin 8. (950 aa)
F1Q5G8_DANRESi:dkey-49n23.1; Belongs to the semaphorin family. (758 aa)
spawSouthpaw. (411 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
tfcp2l1Transcription factor CP2-like 1. (468 aa)
hcn4Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4. (1130 aa)
lmcd1LIM and cysteine-rich domains 1. (342 aa)
foxi1Forkhead box I1. (377 aa)
gata4GATA-binding protein 4. (352 aa)
sox17SRY-box transcription factor 17. (413 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
gata6GATA-binding protein 6. (501 aa)
LIN28ASi:ch1073-284b18.2. (193 aa)
sox32SRY-box transcription factor 32. (307 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
ndr2Nodal-related 2. (505 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
zeb2aZinc finger E-box-binding homeobox 2a. (1242 aa)
esrrbEstrogen-related receptor beta. (437 aa)
msx1aMuscle segment homeobox 1a. (233 aa)
tbxtbT-box transcription factor Tb. (427 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.