STRINGSTRING
tbx16 tbx16 prdm1a prdm1a lft1 lft1 foxa2 foxa2 nkx2.5 nkx2.5 shox2 shox2 noto noto hand2 hand2 tbx3a tbx3a gata5 gata5 tbx20 tbx20 wt1a wt1a tbx5a tbx5a tdgf1 tdgf1 pitx2 pitx2 dand5 dand5 tcf21 tcf21 klf17 klf17 lft2 lft2 sall4 sall4 pou5f3 pou5f3 ndr1 ndr1 gsc gsc mef2ca mef2ca tbx18 tbx18 sox2 sox2 klf4 klf4 myca myca nanog nanog foxa foxa mixl1 mixl1 pcdh8 pcdh8 F1Q5G8_DANRE F1Q5G8_DANRE spaw spaw tfcp2l1 tfcp2l1 hcn4 hcn4 lmcd1 lmcd1 gata4 gata4 sox17 sox17 gata6 gata6 LIN28A LIN28A sox32 sox32 ndr2 ndr2 tbxta tbxta esrrb esrrb tbxtb tbxtb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx16T-box transcription factor 16. (470 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
nkx2.5NK2 homeobox 5. (314 aa)
shox2Short stature homeobox 2. (299 aa)
notoNotochord homeobox. (241 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
tbx3aT-box transcription factor 3a. (689 aa)
gata5Transcription factor gata5. (383 aa)
tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
wt1aWT1 transcription factor a. (419 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
dand5DAN domain family, member 5. (243 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
klf17Kruppel-like factor 17. (409 aa)
lft2Left-right determination factor. (362 aa)
sall4Spalt-like transcription factor 4. (1091 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
ndr1Nodal-related 1. (392 aa)
gscHomeobox protein goosecoid. (240 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
tbx18T-box transcription factor 18. (554 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
klf4Kruppel-like factor 4. (340 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
nanogOvary-expressed homeobox protein. (384 aa)
foxaForkhead box A sequence. (355 aa)
mixl1Mix paired-like homeobox. (327 aa)
pcdh8Protocadherin 8. (950 aa)
F1Q5G8_DANRESi:dkey-49n23.1; Belongs to the semaphorin family. (758 aa)
spawSouthpaw. (411 aa)
tfcp2l1Transcription factor CP2-like 1. (468 aa)
hcn4Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4. (1130 aa)
lmcd1LIM and cysteine-rich domains 1. (342 aa)
gata4GATA-binding protein 4. (352 aa)
sox17SRY-box transcription factor 17. (413 aa)
gata6GATA-binding protein 6. (501 aa)
LIN28ASi:ch1073-284b18.2. (193 aa)
sox32SRY-box transcription factor 32. (307 aa)
ndr2Nodal-related 2. (505 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
esrrbEstrogen-related receptor beta. (437 aa)
tbxtbT-box transcription factor Tb. (427 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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