STRINGSTRING
mespaa mespaa her7 her7 tbx6 tbx6 dlc dlc hes6 hes6 her1 her1 uncx4.1 uncx4.1 mespab mespab ripply2 ripply2 msgn1 msgn1 meox1 meox1 tbx16l tbx16l mespba mespba ripply1 ripply1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mespaaMesp-related bHLH transcription factor mesp-a. (223 aa)
her7Hairy and enhancer of split-related-7. (206 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
dlcDelta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa)
hes6Hes family bHLH transcription factor 6. (226 aa)
her1Hairy-related 1. (328 aa)
uncx4.1Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis; Belongs to the paired homeobox family. Unc-4 subfamily. (470 aa)
mespabMesoderm posterior ab. (240 aa)
ripply2Protein ripply2; Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity). (109 aa)
msgn1Mesogenin-1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). (131 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
tbx16lT-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa)
mespbaMesoderm posterior ba. (236 aa)
ripply1Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. (140 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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