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| | wnt10a | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development. Regulates the expression of genes involved in tooth development. Belongs to the Wnt family. (442 aa) |
| | fzd9b | Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | wnt7ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | prickle2a | Prickle homolog 2a. (869 aa) |
| | wls | Wnt ligand secretion mediator. (542 aa) |
| | dkk1a | Dickkopf WNT-signaling pathway inhibitor 1a. (256 aa) |
| | nkd2a | Protein naked cuticle homolog 2-like; Cell autonomous antagonist of both the canonical and non- canonical Wnt signaling pathways; Belongs to the NKD family. (409 aa) |
| | wif1 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. (378 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | daam1a | Dishevelled-associated activator of morphogenesis 1a. (1084 aa) |
| | daam1b | Dishevelled-associated activator of morphogenesis 1b. (1079 aa) |
| | frzb | Frizzled-related protein. (315 aa) |
| | vangl1 | Vang-like protein. (527 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | fzd5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | fzd7b | Frizzled class receptor 7b; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | celsr1a | Cadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family. (3044 aa) |
| | shisa2a | Shisa family member 2a. (258 aa) |
| | porcn | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (442 aa) |
| | wnt2bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | notum1a | Palmitoleoyl-protein carboxylesterase notum1a; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway. Acts by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity); Belongs to the pectinacetylesterase family. Notum subfamily. (500 aa) |
| | tspan12 | Tetraspanin. (301 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | sfrp1a | Secreted frizzled-related protein 1a. (296 aa) |
| | wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | fzd8b | Frizzled class receptor 8b; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa) |
| | sfrp5 | Secreted frizzled-related protein 5. (310 aa) |
| | rspo3 | R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and prunin [...] (317 aa) |
| | prickle1a | Prickle homolog 1a. (793 aa) |
| | wnt10b | Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer. (427 aa) |
| | wnt2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). (350 aa) |
| | wnt7aa | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | dkk1b | Dickkopf WNT-signaling pathway inhibitor 1b. (241 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | porcnl | Porcupine O-acyltransferase-like; Belongs to the membrane-bound acyltransferase family. (449 aa) |
| | fzd2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) |
| | wnt1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa) |
| | ryk | Receptor-like tyrosine kinase. (604 aa) |
| | sfrp1b | Secreted frizzled-related protein 1b. (300 aa) |
| | LOC568110 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | celsr2 | Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2940 aa) |
| | sost | Sclerostin. (210 aa) |
| | fzd3a | Transmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa) |
| | kremen1 | Kringle-containing transmembrane protein 1. (465 aa) |
| | F1QQA9_DANRE | Si:ch211-81a5.1. (301 aa) |
| | dvl3a | Dishevelled segment polarity protein 3a. (676 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | fzd10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (294 aa) |
| | llgl1 | LLGL scribble cell polarity complex component 1. (304 aa) |
| | wnt2ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | dvl1b | Dishevelled segment polarity protein 1b. (716 aa) |
| | dkk3b | Dickkopf WNT-signaling pathway inhibitor 3b. (283 aa) |
| | wnt4 | Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa) |
| | dkk2 | Dickkopf WNT-signaling pathway inhibitor 2. (243 aa) |
| | wnt4b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | rspo2 | R-spondin 2_variant1. (248 aa) |
| | ror2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa) |
| | adgra2 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] (1367 aa) |
| | wnt6b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa) |
| | fzd7a | Frizzled class receptor 7a; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa) |
| | fzd3b | Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa) |
| | trabd2a | Metalloprotease TIKI1; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation (By similarity). (494 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | wnt8a | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa) |
| | celsr3 | Cadherin, EGF LAG seven-pass G-type receptor 3. (2065 aa) |
| | ror1 | Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa) |
| | ankrd6b | Ankyrin repeat domain 6b. (728 aa) |
| | prickle1b | Prickle homolog 1b. (863 aa) |
| | celsr2-2 | Cadherin, EGF LAG seven-pass G-type receptor 2. (85 aa) |
| | wnt8-2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa) |
| | rspo4 | R-spondin 4. (246 aa) |
| | ndp | Norrin cystine knot growth factor NDP. (138 aa) |
| | notum2 | Carboxylesterase notum2; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling. (495 aa) |
| | I3ITC3_DANRE | Si:dkey-217d24.6. (995 aa) |
| | fzd9a | Frizzled class receptor 9a; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | wnt7bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | dact1 | Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to activate the canonical Wnt signaling pathway. (616 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | reck | Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. Adgra2 is then required to deliver reck-bound Wnt7 to frizzled [...] (755 aa) |
| | lrp6 | Low density lipoprotein receptor-related protein 6. (935 aa) |
| | rspo1 | R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Belongs to the R-spondin family. (261 aa) |
| | prickle2b | Prickle homolog 2b. (840 aa) |
| | lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (971 aa) |
| | wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | fzd4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa) |
| | APCDD1 | APC down-regulated 1. (484 aa) |
| | fzd6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa) |
| | dvl3 | Dishevelled segment polarity protein 3b. (706 aa) |
| | nkd1 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa) |
| | fzd1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa) |
| | sfrp2l | Secreted frizzled-related protein 2-like. (333 aa) |
| | notum1b | Inactive palmitoleoyl-protein carboxylesterase notum1b. (49 aa) |
| | znrf3 | E3 ubiquitin-protein ligase znrf3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Belongs to the ZNRF3 family. (866 aa) |
