(23 nodes) Heteromeric SMAD protein complex, and Signaling by BMP network (Danio rerio)

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Your Input:
	smurf1	E3 ubiquitin-protein ligase. (731 aa)
	acvr1ba	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
	smad7	Mothers against decapentaplegic homolog. (372 aa)
	smad3b	Mothers against decapentaplegic homolog. (423 aa)
	acvrl1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (499 aa)
	smad3a	Mothers against decapentaplegic homolog. (425 aa)
	smad5	Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
	smurf2	E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (765 aa)
	foxh1	Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
	gdf2	Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/eng. (389 aa)
	bmp10	Bone morphogenetic protein 10. (485 aa)
	smad6b	Mothers against decapentaplegic homolog. (486 aa)
	skia	V-ski avian sarcoma viral oncogene homolog a. (727 aa)
	smad4a	Mothers against decapentaplegic homolog. (547 aa)
	gb:cr929477	SMAD family member 4. (332 aa)
	skilb	SKI-like proto-oncogene b. (624 aa)
	acvr2ba	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	smad2	Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
	bmpr2b	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
	smad6a	Mothers against decapentaplegic homolog. (456 aa)
	Q1L8R8_DANRE	Mothers against decapentaplegic homolog. (571 aa)
	E7FFZ5_DANRE	Mothers against decapentaplegic homolog. (568 aa)
	smad9	Mothers against decapentaplegic homolog. (466 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E7FFZ5_DANRE	Q1L8R8_DANRE	ENSDARP00000124579	ENSDARP00000120222	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.544
E7FFZ5_DANRE	foxh1	ENSDARP00000124579	ENSDARP00000072485	Mothers against decapentaplegic homolog.	Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.	0.408
E7FFZ5_DANRE	skia	ENSDARP00000124579	ENSDARP00000091440	Mothers against decapentaplegic homolog.	V-ski avian sarcoma viral oncogene homolog a.	0.809
E7FFZ5_DANRE	skilb	ENSDARP00000124579	ENSDARP00000105507	Mothers against decapentaplegic homolog.	SKI-like proto-oncogene b.	0.627
E7FFZ5_DANRE	smad2	ENSDARP00000124579	ENSDARP00000106756	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.	0.955
E7FFZ5_DANRE	smad3a	ENSDARP00000124579	ENSDARP00000045373	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.955
E7FFZ5_DANRE	smad3b	ENSDARP00000124579	ENSDARP00000043454	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.955
E7FFZ5_DANRE	smad4a	ENSDARP00000124579	ENSDARP00000097763	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.547
E7FFZ5_DANRE	smad5	ENSDARP00000124579	ENSDARP00000054174	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family.	0.953
E7FFZ5_DANRE	smad6a	ENSDARP00000124579	ENSDARP00000112408	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.697
E7FFZ5_DANRE	smad6b	ENSDARP00000124579	ENSDARP00000091342	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.697
E7FFZ5_DANRE	smad7	ENSDARP00000124579	ENSDARP00000024277	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.697
E7FFZ5_DANRE	smad9	ENSDARP00000124579	ENSDARP00000131023	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.953
E7FFZ5_DANRE	smurf1	ENSDARP00000124579	ENSDARP00000003721	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.438
E7FFZ5_DANRE	smurf2	ENSDARP00000124579	ENSDARP00000055490	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.508
Q1L8R8_DANRE	E7FFZ5_DANRE	ENSDARP00000120222	ENSDARP00000124579	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.544
Q1L8R8_DANRE	foxh1	ENSDARP00000120222	ENSDARP00000072485	Mothers against decapentaplegic homolog.	Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.	0.408
Q1L8R8_DANRE	skia	ENSDARP00000120222	ENSDARP00000091440	Mothers against decapentaplegic homolog.	V-ski avian sarcoma viral oncogene homolog a.	0.809
Q1L8R8_DANRE	skilb	ENSDARP00000120222	ENSDARP00000105507	Mothers against decapentaplegic homolog.	SKI-like proto-oncogene b.	0.627
Q1L8R8_DANRE	smad2	ENSDARP00000120222	ENSDARP00000106756	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.	0.955

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