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gdf5 gdf5 acvr1l acvr1l bmp2a bmp2a bmpr1aa bmpr1aa bmp7a bmp7a rgmb rgmb bmp6 bmp6 rgma rgma smad1 smad1 grem1a grem1a chrd chrd hjv hjv tll1 tll1 bmp4 bmp4 nog3 nog3 nog1 nog1 bmp8a bmp8a bmp2b bmp2b nog2 nog2 gdf7 gdf7 bmp7b bmp7b rgmd rgmd grem2a grem2a twsg1a twsg1a bmpr1bb bmpr1bb grem2b grem2b tfr2 tfr2 bmper bmper szl szl bmp5 bmp5 nbl1 nbl1 grem1b grem1b bmpr1ba bmpr1ba bmpr1ab bmpr1ab twsg1b twsg1b bmp16 bmp16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gdf5Growth differentiation factor 5. (474 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
rgmbRepulsive guidance molecule BMP co-receptor b. (436 aa)
bmp6Bone morphogenetic protein 6. (417 aa)
rgmaRepulsive guidance molecule BMP co-receptor a. (449 aa)
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
grem1aGremlin. (177 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
hjvHemojuvelin BMP co-receptor. (410 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
bmp8aBone morphogenetic protein 8a. (433 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
gdf7Growth differentiation factor 7. (396 aa)
bmp7bBone morphogenetic protein 7b. (427 aa)
rgmdRGM domain family, member D. (458 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
twsg1aTwisted gastrulation protein homolog 1-A; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization (By similarity); Belongs to the twisted gastrulation protein family. (217 aa)
bmpr1bbSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
grem2bGremlin. (166 aa)
tfr2Transferrin receptor 2. (783 aa)
bmperBMP-binding endothelial regulator. (667 aa)
szlSzl protein. (282 aa)
bmp5Bone morphogenetic protein 5. (446 aa)
nbl1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family. (86 aa)
grem1bGremlin 1b. (204 aa)
bmpr1baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
bmpr1abReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
twsg1bTwisted gastrulation protein homolog 1-B; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization; Belongs to the twisted gastrulation protein family. (155 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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