STRINGSTRING
flt1 flt1 nradd nradd epha4l epha4l mst1rb mst1rb anos1a anos1a fgf1a fgf1a memo1 memo1 erbb2 erbb2 bdnf bdnf fgfr3 fgfr3 fgfr1a fgfr1a igf2a igf2a etv4 etv4 igf1ra igf1ra igf1 igf1 fgf8a fgf8a ntrk1 ntrk1 anos1b anos1b marcksb marcksb insra insra cbl cbl cblb cblb crkl crkl angpt1 angpt1 kitb kitb igf1rb igf1rb ptpn11b ptpn11b igf2b igf2b fgf10a fgf10a kdr kdr fgf5 fgf5 spry2 spry2 irs2a irs2a igfbp5b igfbp5b fgf24 fgf24 tek tek slx4ip slx4ip igfbp5a igfbp5a fgf8b fgf8b fgf14 fgf14 fgf16 fgf16 ptpn1 ptpn1 fgf18b fgf18b ngfb ngfb etv5b etv5b fgf23 fgf23 fgf6b fgf6b frs2a frs2a igfbp2a igfbp2a egf egf pdgfc pdgfc fgfr1b fgfr1b angpt2b angpt2b tgfa tgfa irs1 irs1 prox1a prox1a crk crk kitlgb kitlgb flt3 flt3 ptpn11a ptpn11a ntf3 ntf3 fgfrl1a fgfrl1a pappab pappab hyal2a hyal2a adamts3 adamts3 pecam1 pecam1 sos2 sos2 fgf12b fgf12b ENSDARP00000086547 ENSDARP00000086547 erbb4a erbb4a shc1 shc1 csf1b csf1b nrg2a nrg2a spry4 spry4 hgfa hgfa vegfc vegfc pdgfra pdgfra pdgfaa pdgfaa insrb insrb kita kita cblc cblc hbegfa hbegfa kl kl pdgfd pdgfd kitlga kitlga csf1a csf1a fgf22 fgf22 nitr1a nitr1a fgf9 fgf9 cdh5 cdh5 lyve1a lyve1a erbb3b erbb3b nrg3b nrg3b bcar1 bcar1 ccbe1 ccbe1 fgf18a fgf18a fgf20b fgf20b il34 il34 nr2f2 nr2f2 prok2 prok2 nrg2b nrg2b hbegfb hbegfb irs4a irs4a rapgef1b rapgef1b ngfra ngfra sox18 sox18 chd7 chd7 shc2 shc2 frs2b frs2b insb insb rapgef1a rapgef1a fgf11a fgf11a stab2 stab2 gab1 gab1 LOC569566 LOC569566 ntrk2a ntrk2a vegfab vegfab sh3kbp1 sh3kbp1 vegfd vegfd csf1rb csf1rb grapb grapb fgf7 fgf7 grb2b grb2b igfals igfals F1QGV9_DANRE F1QGV9_DANRE met met erbb3a erbb3a fgfr2 fgfr2 fgf11b fgf11b H0WED3_DANRE H0WED3_DANRE egfra egfra ngfrb ngfrb pgfb pgfb frs3 frs3 fgfbp1a fgfbp1a nrg1 nrg1 fgf3 fgf3 fgf2 fgf2 flt4 flt4 vegfaa vegfaa grb2a grb2a grap2b grap2b kdrl kdrl pappaa pappaa igfbp3 igfbp3 nsmfb nsmfb spry1 spry1 igfbp1a igfbp1a fgf19 fgf19 fgf4 fgf4 irs2b irs2b ngfa ngfa btc btc mrc1a mrc1a ENSDARP00000137311 ENSDARP00000137311 fgf17 fgf17 fgfrl1b fgfrl1b SHC3 SHC3 ntrk3a ntrk3a pdgfab pdgfab angpt2a angpt2a il17rd il17rd fgf21 fgf21 klb klb sos1 sos1 fgfr4 fgfr4 epgn epgn pdgfba pdgfba pdgfbb pdgfbb angpt4 angpt4 tie1 tie1 ptpn6 ptpn6 csf1ra csf1ra prokr1b prokr1b pdgfrb pdgfrb lyve1b lyve1b erbb4b erbb4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
nraddNeurotrophin receptor-associated death domain. (413 aa)
epha4lEph receptor A4,-like. (988 aa)
mst1rbMacrophage-stimulating 1 receptor b. (1380 aa)
anos1aAnosmin 1a. (652 aa)
fgf1aPutative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)
memo1Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity); Belongs to the MEMO1 family. (297 aa)
erbb2Receptor protein-tyrosine kinase. (1275 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
etv4ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
igf1Insulin-like growth factor 1b. (161 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
ntrk1Tyrosine-protein kinase receptor. (797 aa)
anos1bAnosmin 1b. (633 aa)
marcksbMyristoylated alanine-rich protein kinase C substrate b. (227 aa)
insraTyrosine-protein kinase receptor. (1353 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (913 aa)
cblbCbl proto-oncogene B, E3 ubiquitin protein ligase. (939 aa)
crklV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa)
angpt1Angiopoietin 1. (513 aa)
kitbMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (957 aa)
igf1rbTyrosine-protein kinase receptor. (1380 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
igf2bInsulin-like growth factor 2b. (212 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
kdrVascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
spry2Sprouty RTK-signaling antagonist 2. (301 aa)
irs2aInsulin receptor substrate 2a. (1032 aa)
igfbp5bInsulin-like growth factor-binding protein 5b. (265 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
tekTyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)
slx4ipProtein SLX4IP; Belongs to the SLX4IP family. (499 aa)
igfbp5aInsulin-like growth factor-binding protein 5a. (268 aa)
fgf8bFibroblast growth factor 8b; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system. (212 aa)
fgf14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
ptpn1Protein tyrosine phosphatase non-receptor type 1. (350 aa)
fgf18bFibroblast growth factor 18b; Belongs to the heparin-binding growth factors family. (213 aa)
ngfbNerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity). (194 aa)
etv5bETS variant transcription factor 5b. (524 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (258 aa)
fgf6bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
frs2aFibroblast growth factor receptor substrate 2a. (485 aa)
igfbp2aInsulin-like growth factor-binding protein 2-A; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (276 aa)
egfEpidermal growth factor. (1114 aa)
pdgfcPlatelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
angpt2bAngiopoietin 2b. (489 aa)
tgfaTransforming growth factor, alpha. (191 aa)
irs1Insulin receptor substrate 1. (1099 aa)
prox1aProspero homeobox 1a. (739 aa)
crkV-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa)
kitlgbKit ligand b. (267 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (243 aa)
fgfrl1aFibroblast growth factor receptor-like 1a. (483 aa)
pappabPregnancy-associated plasma protein A, pappalysin 1b. (1624 aa)
hyal2aHyaluronidase. (475 aa)
adamts3ADAM metallopeptidase with thrombospondin type 1 motif, 3. (1164 aa)
pecam1Platelet/endothelial cell adhesion molecule 1. (738 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1341 aa)
fgf12bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
ENSDARP00000086547Receptor protein-tyrosine kinase. (1392 aa)
erbb4aReceptor protein-tyrosine kinase. (1388 aa)
shc1SHC (Src homology 2 domain-containing)-transforming protein 1. (454 aa)
csf1bColony-stimulating factor 1b (macrophage). (284 aa)
nrg2aZgc:162973 protein. (488 aa)
spry4Sprouty homolog 4 (Drosophila). (310 aa)
hgfaHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (699 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
pdgfaaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa)
insrbTyrosine-protein kinase receptor. (1348 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
cblcCbl proto-oncogene C, E3 ubiquitin protein ligase. (502 aa)
hbegfaHeparin-binding EGF-like growth factor a. (230 aa)
klKlotho. (990 aa)
pdgfdPlatelet-derived growth factor d. (372 aa)
kitlgaKit ligand a. (272 aa)
csf1aColony-stimulating factor 1a (macrophage). (526 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
nitr1aNovel immune-type receptor 1a, allele 3. (329 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
lyve1aLymphatic vessel endothelial hyaluronic receptor 1a. (328 aa)
erbb3bErb-b2 receptor tyrosine kinase 3b. (1429 aa)
nrg3bNeuregulin 3b. (764 aa)
bcar1BCAR1 scaffold protein, Cas family member. (919 aa)
ccbe1Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
il34Si:ch211-239j19.3 protein. (213 aa)
nr2f2Drosophila seven-up homolog/mammalian ARP-1 homolog. (422 aa)
prok2Prokineticin 2. (107 aa)
nrg2bNeuregulin 2b. (705 aa)
hbegfbHeparin-binding EGF-like growth factor b. (263 aa)
irs4aInsulin receptor substrate 4a. (1051 aa)
rapgef1bRap guanine nucleotide exchange factor (GEF) 1b. (1188 aa)
ngfraNerve growth factor receptor a (TNFR superfamily, member 16). (346 aa)
sox18SRY-box transcription factor 18. (431 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
shc2SHC (Src homology 2 domain-containing)-transforming protein 2. (501 aa)
frs2bFibroblast growth factor receptor substrate 2b. (508 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
rapgef1aRap guanine nucleotide exchange factor (GEF) 1a. (1077 aa)
fgf11aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
stab2Stabilin 2. (2543 aa)
gab1GRB2-associated-binding protein 1. (740 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
ntrk2aTyrosine-protein kinase receptor. (784 aa)
vegfabVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa)
sh3kbp1SH3-domain kinase-binding protein 1. (669 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
csf1rbColony-stimulating factor 1 receptor, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
grapbGRB2-related adaptor protein b. (214 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
igfalsInsulin-like growth factor-binding protein, acid labile subunit. (614 aa)
F1QGV9_DANREPhosphoinositide phospholipase C. (476 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
erbb3aErb-b2 receptor tyrosine kinase 3a. (1319 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
fgf11bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
H0WED3_DANRESi:ch211-197k17.3. (208 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
ngfrbNerve growth factor receptor b. (431 aa)
pgfbPlacental growth factor b; Belongs to the PDGF/VEGF growth factor family. (164 aa)
frs3Fibroblast growth factor receptor substrate 3. (627 aa)
fgfbp1aFibroblast growth factor-binding protein 1b. (197 aa)
nrg1Neuregulin 1. (730 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
grb2aGrowth factor receptor-bound protein 2a. (217 aa)
grap2bGRB2-related adaptor protein 2b. (249 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
pappaaPregnancy-associated plasma protein A, pappalysin 1a. (1627 aa)
igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
nsmfbNMDA receptor synaptonuclear signaling and neuronal migration factor; Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. (570 aa)
spry1Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). (292 aa)
igfbp1aInsulin-like growth factor-binding protein 1a. (262 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
irs2bInsulin receptor substrate 2b. (1062 aa)
ngfaNeurotrophin-7; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF; Belongs to the NGF-beta family. (233 aa)
btcBetacellulin, epidermal growth factor family member. (178 aa)
mrc1aMannose receptor, C type 1a. (1440 aa)
ENSDARP00000137311Si:dkey-237i9.8. (686 aa)
fgf17Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family. (215 aa)
fgfrl1bFibroblast growth factor receptor-like 1b. (481 aa)
SHC3SHC adaptor protein 3. (347 aa)
ntrk3aTyrosine-protein kinase receptor. (821 aa)
pdgfabPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
angpt2aAngiopoietin 2a. (488 aa)
il17rdInterleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa)
fgf21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (194 aa)
klbKlotho beta. (994 aa)
sos1Son of sevenless homolog 1 (Drosophila). (714 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
epgnEpithelial mitogen homolog (mouse). (148 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
angpt4Angiopoietin 4. (499 aa)
tie1Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1150 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
prokr1bPutative prokineticin receptor; Belongs to the G-protein coupled receptor 1 family. (396 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1072 aa)
lyve1bLymphatic vessel endothelial hyaluronic receptor 1b. (355 aa)
erbb4bReceptor protein-tyrosine kinase. (857 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (20%) [HD]