STRINGSTRING
prox1a prox1a adamts3 adamts3 pecam1 pecam1 cdh5 cdh5 ccbe1 ccbe1 nr2f2 nr2f2 sox18 sox18 vegfd vegfd flt4 flt4 mrc1a mrc1a ENSDARP00000137311 ENSDARP00000137311 ptpn6 ptpn6 lyve1b lyve1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prox1aProspero homeobox 1a. (739 aa)
adamts3ADAM metallopeptidase with thrombospondin type 1 motif, 3. (1164 aa)
pecam1Platelet/endothelial cell adhesion molecule 1. (738 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
ccbe1Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa)
nr2f2Drosophila seven-up homolog/mammalian ARP-1 homolog. (422 aa)
sox18SRY-box transcription factor 18. (431 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
mrc1aMannose receptor, C type 1a. (1440 aa)
ENSDARP00000137311Si:dkey-237i9.8. (686 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
lyve1bLymphatic vessel endothelial hyaluronic receptor 1b. (355 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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