STRINGSTRING
gfra2a gfra2a ret ret gfra2b gfra2b gfra4a gfra4a LOC101883396 LOC101883396 gdnfa gdnfa artna artna gfra1a gfra1a gfra1b gfra1b nrtn nrtn LOC103910147 LOC103910147 ENSDARP00000155002 ENSDARP00000155002
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gfra2aGDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (495 aa)
retProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa)
gfra2bGDNF family receptor alpha 2b. (315 aa)
gfra4aGDNF family receptor alpha 4a. (437 aa)
LOC101883396Artemin b. (189 aa)
gdnfaGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa)
artnaArtemin a. (104 aa)
gfra1aGdnf family receptor alpha 1a. (97 aa)
gfra1bGDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (481 aa)
nrtnNeurturin. (211 aa)
LOC103910147TGF_BETA_2 domain-containing protein. (231 aa)
ENSDARP00000155002TGF_BETA_2 domain-containing protein. (159 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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