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epha2a epha2a efna1b efna1b robo2 robo2 efna3a efna3a sema3b sema3b plxnb3 plxnb3 sgsm3 sgsm3 plxna4 plxna4 epha3 epha3 efnb1 efnb1 slit2 slit2 epha4b epha4b sema3ga sema3ga ntn1b ntn1b ephb3a ephb3a efna2a efna2a abl2 abl2 plxnb2b plxnb2b plxna3 plxna3 epha2b epha2b rnd1a rnd1a sema3fa sema3fa efna1a efna1a sema3aa sema3aa sema3e sema3e nrp2b nrp2b sema3ab sema3ab efnb3b efnb3b sema3h sema3h epha5 epha5 efnb2b efnb2b E7EXX6_DANRE E7EXX6_DANRE raph1b raph1b abi3b abi3b robo1 robo1 ephb4b ephb4b sema4d sema4d dscamb dscamb nrp1b nrp1b sema3d sema3d epha7 epha7 dlg5a dlg5a ek1 ek1 Q5RHX7_DANRE Q5RHX7_DANRE LOC100332721 LOC100332721 sema4e sema4e sdk1a sdk1a efna2b efna2b sema3gb sema3gb slit1a slit1a sema7a sema7a map1sb map1sb sema3c sema3c ephb1 ephb1 plxnd1 plxnd1 slit3 slit3 robo4 robo4 ephb2a ephb2a Q5RH90_DANRE Q5RH90_DANRE ephb6 ephb6 plxnc1 plxnc1 efna5a efna5a zgc:77784 zgc:77784 sema6d sema6d epha4a epha4a fes fes abl1 abl1 nrp2a nrp2a ntn2 ntn2 farp2 farp2 plxnb2a plxnb2a plxnb1b plxnb1b draxin draxin ntn4 ntn4 evlb evlb unc5b unc5b sema6a sema6a efna3b efna3b ntn1a ntn1a gipc1 gipc1 dscaml1 dscaml1 ENSDARP00000134495 ENSDARP00000134495 efna5b efna5b dcc dcc neo1a neo1a sema5a sema5a plxnb1a plxnb1a mapre2 mapre2 unc5a unc5a ENSDARP00000140419 ENSDARP00000140419 nrp1a nrp1a plxna1a plxna1a ntn5 ntn5 lrrc4cb lrrc4cb LOC559501 LOC559501 efnb3a efnb3a ENSDARP00000145392 ENSDARP00000145392 robo2-2 robo2-2 dhrs13b.1-2 dhrs13b.1-2 slit1b slit1b ENSDARP00000151788 ENSDARP00000151788 lrrc4ca lrrc4ca plxna2 plxna2 ENSDARP00000152912 ENSDARP00000152912 ENSDARP00000153487 ENSDARP00000153487 dscama dscama ntng1a ntng1a si:dkey-1c11.1 si:dkey-1c11.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
epha2aEph receptor A2 a. (984 aa)
efna1bEphrin A-L1; Belongs to the ephrin family. (229 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
efna3aEphrin-A3a; Belongs to the ephrin family. (220 aa)
sema3bSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (775 aa)
plxnb3Plexin B3. (1886 aa)
sgsm3Small G protein signaling modulator 3; Belongs to the small G protein signaling modulator family. (755 aa)
plxna4Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. (1903 aa)
epha3Ephrin type-A receptor 3. (963 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (341 aa)
slit2Slit homolog 2 (Drosophila). (1512 aa)
epha4bEph receptor A4b. (976 aa)
sema3gaSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga; Belongs to the semaphorin family. (749 aa)
ntn1bNetrin 1b. (602 aa)
ephb3aEphrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important re [...] (925 aa)
efna2aEphrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...] (195 aa)
abl2Tyrosine-protein kinase. (1135 aa)
plxnb2bPlexin b2b. (1846 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
epha2bEph receptor A2 b. (979 aa)
rnd1aRas-like protein Rnd1b. (232 aa)
sema3faSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (801 aa)
efna1aEphrin-A1a; Belongs to the ephrin family. (222 aa)
sema3aaSemaphorin-3aa; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion. (860 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
nrp2bNeuropilin; Belongs to the neuropilin family. (920 aa)
sema3abSemaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa)
efnb3bEfnb3 protein; Belongs to the ephrin family. (342 aa)
sema3hSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H; Belongs to the semaphorin family. (749 aa)
epha5Uncharacterized protein. (983 aa)
efnb2bEphrin-B2b; Belongs to the ephrin family. (334 aa)
E7EXX6_DANRESi:dkey-202e22.2. (642 aa)
raph1bRas association (RalGDS/AF-6) and pleckstrin homology domains 1b. (1511 aa)
abi3bABI family, member 3b. (415 aa)
robo1Roundabout, axon guidance receptor, homolog 1 (Drosophila). (1687 aa)
ephb4bEphrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (976 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
dscambDown syndrome cell adhesion molecule b. (2020 aa)
nrp1bNeuropilin 1b. (540 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
epha7Eph receptor A7. (1016 aa)
dlg5aDiscs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa)
ek1Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (981 aa)
Q5RHX7_DANRESi:ch211-127b11.1 protein. (477 aa)
LOC100332721Neogenin 1b. (1413 aa)
sema4eSemaphorin-4E. (766 aa)
sdk1aSidekick cell adhesion molecule 1a. (2159 aa)
efna2bEphrin-A2b; Belongs to the ephrin family. (159 aa)
sema3gbSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb; Belongs to the semaphorin family. (745 aa)
slit1aSlit homolog 1a (Drosophila). (1524 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
map1sbMicrotubule-associated protein 1Sb. (1318 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
ephb1EPH receptor B1. (694 aa)
plxnd1Plexin D1. (398 aa)
slit3Slit homolog 3 (Drosophila). (1516 aa)
robo4Roundabout, axon guidance receptor, homolog 4 (Drosophila). (1134 aa)
ephb2aEph receptor B2a. (1015 aa)
Q5RH90_DANRESi:dkey-183c2.4. (568 aa)
ephb6Receptor protein-tyrosine kinase. (1009 aa)
plxnc1Plexin C1. (1056 aa)
efna5aEphrin-A5a; Belongs to the ephrin family. (237 aa)
zgc:77784Zgc:77784. (171 aa)
sema6dSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (898 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
fesTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (826 aa)
abl1Tyrosine-protein kinase. (1081 aa)
nrp2aNeuropilin; Belongs to the neuropilin family. (927 aa)
ntn2Netrin 2. (609 aa)
farp2FERM, RhoGEF and pleckstrin domain protein 2. (1044 aa)
plxnb2aPlexin b2a. (1864 aa)
plxnb1bPlexin b1b. (2220 aa)
draxinDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family. (360 aa)
ntn4Netrin 4. (639 aa)
evlbEnah/Vasp-like b. (359 aa)
unc5bUnc-5 netrin receptor B. (940 aa)
sema6aSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A. (604 aa)
efna3bEphrin-A3b; Belongs to the ephrin family. (219 aa)
ntn1aNetrin-1a. (603 aa)
gipc1Regulator of G-protein signaling 19-interacting protein 1. (335 aa)
dscaml1Down syndrome cell adhesion molecule-like 1. (1579 aa)
ENSDARP00000134495Uncharacterized protein; Belongs to the semaphorin family. (482 aa)
efna5bEphrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...] (91 aa)
dccDCC netrin 1 receptor. (1200 aa)
neo1aNeogenin 1a. (1428 aa)
sema5aSemaphorin-5A. (1048 aa)
plxnb1aPlexin b1a. (1945 aa)
mapre2Microtubule-associated protein, RP/EB family, member 2. (386 aa)
unc5aUnc-5 netrin receptor A. (860 aa)
ENSDARP00000140419Uncharacterized protein. (501 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
plxna1aPlexin A1a. (1891 aa)
ntn5Netrin 5. (839 aa)
lrrc4cbLeucine-rich repeat-containing 4C, genome duplicate b. (631 aa)
LOC559501Vav 3 guanine nucleotide exchange factor b. (471 aa)
efnb3aEphrin-B3a; Belongs to the ephrin family. (337 aa)
ENSDARP00000145392Sema domain-containing protein. (1885 aa)
robo2-2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (136 aa)
dhrs13b.1-2Dehydrogenase/reductase (SDR family) member 13b.1. (430 aa)
slit1bSlit homolog 1b (Drosophila). (1532 aa)
ENSDARP00000151788Sema domain-containing protein; Belongs to the semaphorin family. (305 aa)
lrrc4caLeucine-rich repeat-containing 4C, genome duplicate a. (647 aa)
plxna2Plexin A2. (1902 aa)
ENSDARP00000152912Si:dkey-246i14.3; Belongs to the ephrin family. (176 aa)
ENSDARP00000153487Eph LBD domain-containing protein. (256 aa)
dscamaDown syndrome cell adhesion molecule a. (2036 aa)
ntng1aNetrin g1a. (546 aa)
si:dkey-1c11.1Si:dkey-1c11.1. (349 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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