Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| caspa | caspbl | ENSDARP00000034228 | ENSDARP00000113551 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Caspase b,-like; Belongs to the peptidase C14A family. | 0.908 |
| caspa | il1b | ENSDARP00000034228 | ENSDARP00000140751 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Interleukin-1. | 0.992 |
| caspa | nlrp1 | ENSDARP00000034228 | ENSDARP00000126513 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | 0.982 |
| caspa | pycard | ENSDARP00000034228 | ENSDARP00000055920 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | 0.997 |
| caspbl | caspa | ENSDARP00000113551 | ENSDARP00000034228 | Caspase b,-like; Belongs to the peptidase C14A family. | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.908 |
| caspbl | il1b | ENSDARP00000113551 | ENSDARP00000140751 | Caspase b,-like; Belongs to the peptidase C14A family. | Interleukin-1. | 0.990 |
| caspbl | nlrp1 | ENSDARP00000113551 | ENSDARP00000126513 | Caspase b,-like; Belongs to the peptidase C14A family. | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | 0.924 |
| caspbl | pycard | ENSDARP00000113551 | ENSDARP00000055920 | Caspase b,-like; Belongs to the peptidase C14A family. | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | 0.993 |
| il1b | caspa | ENSDARP00000140751 | ENSDARP00000034228 | Interleukin-1. | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.992 |
| il1b | caspbl | ENSDARP00000140751 | ENSDARP00000113551 | Interleukin-1. | Caspase b,-like; Belongs to the peptidase C14A family. | 0.990 |
| il1b | nlrp1 | ENSDARP00000140751 | ENSDARP00000126513 | Interleukin-1. | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | 0.426 |
| il1b | pycard | ENSDARP00000140751 | ENSDARP00000055920 | Interleukin-1. | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | 0.902 |
| nlrp1 | caspa | ENSDARP00000126513 | ENSDARP00000034228 | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.982 |
| nlrp1 | caspbl | ENSDARP00000126513 | ENSDARP00000113551 | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | Caspase b,-like; Belongs to the peptidase C14A family. | 0.924 |
| nlrp1 | il1b | ENSDARP00000126513 | ENSDARP00000140751 | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | Interleukin-1. | 0.426 |
| nlrp1 | pycard | ENSDARP00000126513 | ENSDARP00000055920 | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | 0.937 |
| pycard | caspa | ENSDARP00000055920 | ENSDARP00000034228 | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.997 |
| pycard | caspbl | ENSDARP00000055920 | ENSDARP00000113551 | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | Caspase b,-like; Belongs to the peptidase C14A family. | 0.993 |
| pycard | il1b | ENSDARP00000055920 | ENSDARP00000140751 | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | Interleukin-1. | 0.902 |
| pycard | nlrp1 | ENSDARP00000055920 | ENSDARP00000126513 | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] | NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] | 0.937 |