STRINGSTRING
cgas cgas traf3 traf3 ikbke ikbke irf3 irf3 tbkbp1 tbkbp1 tbk1 tbk1 tank tank irf5 irf5 sting1 sting1 tlr9 tlr9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cgasCyclic GMP-AMP synthase. (592 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
irf3Interferon regulatory factor 3. (426 aa)
tbkbp1TBK1-binding protein 1. (632 aa)
tbk1TANK-binding kinase 1. (727 aa)
tankTRAF family member-associated NFKB activator. (348 aa)
irf5Interferon regulatory factor 5. (516 aa)
sting1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). [...] (398 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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