STRINGSTRING
casp3a casp3a apaf1 apaf1 parp1 parp1 tnfb tnfb tnfrsf1a tnfrsf1a hdr hdr ripk1l ripk1l xiap xiap baxa baxa parp3 parp3 bcl2l1 bcl2l1 bnip4 bnip4 cycsb cycsb zgc:73226 zgc:73226 bnip3lb bnip3lb cradd cradd traf2a traf2a casp9 casp9 tradd tradd bik bik badb badb casp3b casp3b casp21 casp21 cflara cflara gzm3.2 gzm3.2 gzm3 gzm3 fas fas traf1 traf1 casp8 casp8 bcl2l11 bcl2l11 mcl1a mcl1a birc2 birc2 B0S6V5_DANRE B0S6V5_DANRE tnfrsf1b tnfrsf1b pmaip1 pmaip1 tnfrsfa tnfrsfa LOC798445 LOC798445 casp2 casp2 bcl2l10 bcl2l10 bada bada ripk3 ripk3 gzm3.4 gzm3.4 parp4 parp4 huwe1 huwe1 gzm3.3 gzm3.3 bcl2a bcl2a pidd1 pidd1 cflarb cflarb bokb bokb tnfaip3 tnfaip3 boka boka mcl1b mcl1b bcl2b bcl2b LOC100004321 LOC100004321 casp20 casp20 casp22 casp22 faslg faslg zgc:153993 zgc:153993 fadd fadd tnip1 tnip1 bnip3 bnip3 diabloa diabloa LOC110437957 LOC110437957 casp10 casp10 bida bida
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
hdrHematopoietic death receptor. (418 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
xiapX-linked inhibitor of apoptosis. (405 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
parp3Poly [ADP-ribose] polymerase. (531 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
bnip4BCL2-interacting protein 4. (177 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
zgc:73226Zgc:73226. (187 aa)
bnip3lbBCL2-interacting protein 3-like b. (213 aa)
craddCASP2 and RIPK1 domain-containing adaptor with death domain. (200 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
bikBCL2-interacting killer (Apoptosis-inducing). (154 aa)
badbBCL2-associated agonist of cell death b. (147 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
casp21Caspase 21, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (266 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
gzm3.2Granzyme 3, tandem duplicate 2. (249 aa)
gzm3Granzyme 3, tandem duplicate 1; Belongs to the peptidase S1 family. (253 aa)
fasFas cell surface death receptor. (293 aa)
traf1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
bcl2l11BCL2-like 11. (176 aa)
mcl1aMCL1 apoptosis regulator, BCL2 family member a. (255 aa)
birc2Baculoviral IAP repeat-containing 2. (647 aa)
B0S6V5_DANRESi:dkey-10c21.1. (254 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
pmaip1Phorbol-12-myristate-13-acetate-induced protein 1. (45 aa)
tnfrsfaTumor necrosis factor receptor superfamily, member a. (436 aa)
LOC798445Uncharacterized protein; Belongs to the peptidase C14A family. (184 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (399 aa)
bcl2l10BCL2-like 10 (Apoptosis facilitator). (176 aa)
badaBCL2-associated agonist of cell death a. (145 aa)
ripk3Receptor-interacting serine-threonine kinase 3. (361 aa)
gzm3.4Granzyme 3, tandem duplicate 4. (251 aa)
parp4Poly [ADP-ribose] polymerase. (1842 aa)
huwe1HECT, UBA and WWE domain-containing E3 ubiquitin protein ligase 1. (4474 aa)
gzm3.3Granzyme 3, tandem duplicate 3; Belongs to the peptidase S1 family. (257 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
pidd1P53-induced death domain protein 1. (942 aa)
cflarbCASP8 and FADD-like apoptosis regulator b. (178 aa)
bokbBcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. (214 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (756 aa)
bokaBcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. (224 aa)
mcl1bMCL1 apoptosis regulator, BCL2 family member b. (228 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
LOC100004321BCL2-associated X, apoptosis regulator a. (197 aa)
casp20Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (347 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
zgc:153993Zgc:153993 protein. (204 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
tnip1TNFAIP3-interacting protein 1. (653 aa)
bnip3BCL2-interacting protein 3. (183 aa)
diabloaDiablo, IAP-binding mitochondrial protein a. (265 aa)
LOC110437957CARD domain-containing protein. (201 aa)
casp10Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (548 aa)
bidaBH3-interacting domain death agonist. (187 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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