STRINGSTRING
aph1b aph1b psen2 psen2 cass4 cass4 picalma picalma tnfrsf21 tnfrsf21 aplp2 aplp2 psenen psenen inpp5d inpp5d appb appb clu clu sorl1 sorl1 appa appa bace1 bace1 zgc:114200 zgc:114200 cntn4 cntn4 ide ide psen1 psen1 ENSDARP00000136668 ENSDARP00000136668 aplp1 aplp1 mmel1 mmel1 adam10a adam10a picalmb picalmb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aph1bGamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). (258 aa)
psen2Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (441 aa)
cass4Cas scaffold protein family member 4. (793 aa)
picalmaPhosphatidylinositol-binding clathrin assembly protein a. (589 aa)
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (637 aa)
aplp2Amyloid beta (A4) precursor-like protein 2. (764 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
inpp5dInositol polyphosphate-5-phosphatase D. (1082 aa)
appbAmyloid beta (A4) precursor protein b. (694 aa)
cluClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats-containing. (2213 aa)
appaAmyloid beta (A4) precursor protein a. (194 aa)
bace1Beta-secretase 1; Belongs to the peptidase A1 family. (221 aa)
zgc:114200Zgc:114200. (253 aa)
cntn4Contactin 4. (1028 aa)
ideNovel protein similar to H.sapiens IDE, insulin-degrading enzyme (IDE, zgc:162603); Belongs to the peptidase M16 family. (998 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
ENSDARP00000136668Ncstrn_small domain-containing protein. (599 aa)
aplp1Amyloid beta (A4) precursor-like protein 1. (723 aa)
mmel1Membrane metallo-endopeptidase-like 1. (765 aa)
adam10aADAM metallopeptidase domain 10a. (763 aa)
picalmbPhosphatidylinositol-binding clathrin assembly protein b. (646 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.