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chpt1 chpt1 rarres3l rarres3l lta4h lta4h pla2g1b pla2g1b isoc2 isoc2 fads2 fads2 pla2g7 pla2g7 pla2g3 pla2g3 pcyt1aa pcyt1aa ptdss1a ptdss1a cept1b cept1b pafah1b1b pafah1b1b gdpd3b gdpd3b pafah1b1a pafah1b1a enpp2 enpp2 cyp2u1 cyp2u1 gdpd1 gdpd1 zgc:101699 zgc:101699 lpcat4 lpcat4 ephx2 ephx2 enpp6 enpp6 LOC100148581 LOC100148581 tmem189 tmem189 cyp2p7 cyp2p7 cyp2p8 cyp2p8 pcyt2 pcyt2 cyp4f3 cyp4f3 lpcat2 lpcat2 pld1b pld1b alox5a alox5a cept1a cept1a selenoi selenoi pla2g4aa pla2g4aa alox12 alox12 pla2g12a pla2g12a gdpd3a gdpd3a lpcat1 lpcat1 lpcat3 lpcat3 cyp2j20 cyp2j20 pafah1b2 pafah1b2 E7EXS7_DANRE E7EXS7_DANRE F1RE58_DANRE F1RE58_DANRE tmem86b tmem86b Q1L946_DANRE Q1L946_DANRE pld1a pld1a pld3 pld3 pld2 pld2 pla2g6 pla2g6 K7DYE2_DANRE K7DYE2_DANRE alox5b.2 alox5b.2 pla2g4f.1 pla2g4f.1 alox5b.1 alox5b.1 pla2g4f.2 pla2g4f.2 pla2g4ab pla2g4ab pla2g15 pla2g15 lcat lcat zgc:92162 zgc:92162 cyp3a65 cyp3a65 g6fl g6fl ptdss2 ptdss2 mboat1 mboat1 rarres3 rarres3 ENSDARP00000142921 ENSDARP00000142921 F1QAH0_DANRE F1QAH0_DANRE ptdss1b ptdss1b ENSDARP00000150791 ENSDARP00000150791 pafah1b3 pafah1b3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
chpt1Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity). (382 aa)
rarres3lRetinoic acid receptor responder 3-like. (170 aa)
lta4hLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
pla2g1bPhospholipase A(2). (151 aa)
isoc2Isochorismatase domain-containing protein 2; Belongs to the isochorismatase family. (197 aa)
fads2Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). (444 aa)
pla2g7Platelet-activating factor acetylhydrolase. (444 aa)
pla2g3Phospholipase A2 group III. (528 aa)
pcyt1aaPhosphate cytidylyltransferase 1, choline, alpha a. (374 aa)
ptdss1aPhosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). (465 aa)
cept1bCholine/ethanolamine phosphotransferase 1b; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (415 aa)
pafah1b1bLissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa)
gdpd3bGlycerophosphodiester phosphodiesterase domain-containing 3b. (320 aa)
pafah1b1aLissencephaly-1 homolog A; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
enpp2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa)
cyp2u1Cytochrome P450, family 2, subfamily U, polypeptide 1; Belongs to the cytochrome P450 family. (533 aa)
gdpd1Glycerophosphodiester phosphodiesterase domain-containing 1. (318 aa)
zgc:101699Zgc:101699. (554 aa)
lpcat4Lysophosphatidylcholine acyltransferase 4. (508 aa)
ephx2Epoxide hydrolase 2, cytoplasmic. (557 aa)
enpp6Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. (459 aa)
LOC100148581Si:ch73-55i23.1. (591 aa)
tmem189Transmembrane protein 189. (274 aa)
cyp2p7Cytochrome P450, family 2, subfamily J, polypeptide 24; Belongs to the cytochrome P450 family. (496 aa)
cyp2p8Cytochrome P450, family 2, subfamily J, polypeptide 23; Belongs to the cytochrome P450 family. (496 aa)
pcyt2Phosphate cytidylyltransferase 2, ethanolamine. (397 aa)
cyp4f3Cytochrome P450, family 4, subfamily F, polypeptide 3; Belongs to the cytochrome P450 family. (313 aa)
lpcat2Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. May catalyze the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3- phosphocholine. May also cataylze the conversion of as well 1-O-alkyl- sn-glycero-3-phosphocholine to 1-O-alkyl-2-acetyl-sn-glycero-3- phosphocholine and 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (By similarity). (529 aa)
pld1bPhospholipase. (1042 aa)
alox5aArachidonate 5-lipoxygenase a. (674 aa)
cept1aCholine/ethanolamine phosphotransferase 1a; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (426 aa)
selenoiSelenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (386 aa)
pla2g4aaCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa)
alox12Arachidonate 12-lipoxygenase. (670 aa)
pla2g12aPhospholipase A2, group XIIA. (198 aa)
gdpd3aGlycerophosphodiester phosphodiesterase domain-containing 3a. (315 aa)
lpcat1Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). (517 aa)
lpcat3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
cyp2j20Cytochrome P450, family 2, subfamily J, polypeptide 20; Belongs to the cytochrome P450 family. (499 aa)
pafah1b2Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2. (228 aa)
E7EXS7_DANRESi:dkey-177p2.18. (433 aa)
F1RE58_DANRESi:ch211-168k14.2. (452 aa)
tmem86bTransmembrane protein 86B. (249 aa)
Q1L946_DANRESi:ch211-212o1.2. (283 aa)
pld1aPhospholipase. (1022 aa)
pld3Phospholipase D family, member 3. (482 aa)
pld2Phospholipase. (927 aa)
pla2g6Phospholipase A2, group VI (cytosolic, calcium-independent). (824 aa)
K7DYE2_DANRESi:ch211-214p16.3. (1069 aa)
alox5b.2Arachidonate 5-lipoxygenase b, tandem duplicate 2. (676 aa)
pla2g4f.1Phospholipase A2. (837 aa)
alox5b.1Arachidonate 5-lipoxygenase b, tandem duplicate 1. (697 aa)
pla2g4f.2Phospholipase A2. (809 aa)
pla2g4abPhospholipase A2. (720 aa)
pla2g15Phospholipase A2, group XV. (469 aa)
lcatLecithin-cholesterol acyltransferase. (425 aa)
zgc:92162Phospholipase A(2). (153 aa)
cyp3a65Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. (517 aa)
g6flG6f-like. (537 aa)
ptdss2Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity); Belongs to the phosphatidyl serine synthase family. (452 aa)
mboat1Membrane-bound O-acyltransferase domain-containing 1; Belongs to the membrane-bound acyltransferase family. (496 aa)
rarres3Retinoic acid receptor responder 3. (165 aa)
ENSDARP00000142921Si:dkey-148a17.5; Belongs to the G-protein coupled receptor 1 family. (339 aa)
F1QAH0_DANRESi:dkey-148a17.6; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ptdss1bPhosphatidylserine synthase 1b. (446 aa)
ENSDARP00000150791Uncharacterized protein. (223 aa)
pafah1b3Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit. (268 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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