STRINGSTRING
cers5 cers5 tlk2 tlk2 celf3b celf3b cers2a cers2a asah1a asah1a degs1 degs1 kdsr kdsr zgc:153896 zgc:153896 galcb galcb ormdl1 ormdl1 ormdl3 ormdl3 cers4b cers4b zgc:158263 zgc:158263 asah1b asah1b cers4a cers4a ugcg ugcg cers3b cers3b s1pr2 s1pr2 galca galca smpd2a smpd2a smpd2b smpd2b enpp7.1 enpp7.1 cers6 cers6 smpd5 smpd5 plpp3 plpp3 gba2 gba2 cers1 cers1 sptssa sptssa enpp7.2 enpp7.2 sgpl1 sgpl1 gba gba spns2 spns2 acer2 acer2 SGPP2 SGPP2 F1QK11_DANRE F1QK11_DANRE sptlc2b sptlc2b ugt8 ugt8 smpd4 smpd4 sptlc2a sptlc2a degs2 degs2 sgpp1 sgpp1 acer3 acer3 sgms1 sgms1 cerk cerk sgms2a sgms2a asah2 asah2 ormdl2 ormdl2 F1QKZ9_DANRE F1QKZ9_DANRE acer1 acer1 zgc:91976 zgc:91976 loxl5b loxl5b sptlc1 sptlc1 smpd1 smpd1 sptssb sptssb sphk2 sphk2 SPHK1 SPHK1 psmf1 psmf1 smpd3 smpd3 cers3a cers3a sptlc3 sptlc3 golga7bb golga7bb cers2b cers2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cers5Ceramide synthase 5. (387 aa)
tlk2Serine/threonine-protein kinase tousled-like 2; Negative regulator of amino acid starvation-induced autophagy; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (697 aa)
celf3bCugbp, Elav-like family member 3b. (442 aa)
cers2aLAG1 homolog, ceramide synthase 2 (S. cerevisiae). (383 aa)
asah1aN-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (390 aa)
degs1Delta(4)-desaturase, sphingolipid 1. (323 aa)
kdsr3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (359 aa)
zgc:153896Zgc:153896. (439 aa)
galcbGalactosylceramidase b. (664 aa)
ormdl1ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. (153 aa)
ormdl3ORM1-like protein 3; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. (153 aa)
cers4bCeramide synthase 4b. (380 aa)
zgc:158263Zgc:158263. (574 aa)
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. (395 aa)
cers4aCeramide synthase 4a. (407 aa)
ugcgUDP-glucose ceramide glucosyltransferase. (438 aa)
cers3bCeramide synthase 3b. (351 aa)
s1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)
galcaGalactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. (660 aa)
smpd2aSphingomyelin phosphodiesterase 2a. (421 aa)
smpd2bSphingomyelin phosphodiesterase 2b. (436 aa)
enpp7.1Ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1. (485 aa)
cers6Ceramide synthase 6. (391 aa)
smpd5Sphingomyelin phosphodiesterase 5; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. (545 aa)
plpp3Phospholipid phosphatase 3. (312 aa)
gba2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (851 aa)
cers1Ceramide synthase 1. (358 aa)
sptssaSerine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSA subfamily. (68 aa)
enpp7.2Ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 2. (484 aa)
sgpl1Sphingosine-1-phosphate lyase 1. (572 aa)
gbaGlucosylceramidase. (518 aa)
spns2Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (105 aa)
acer2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (277 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (415 aa)
F1QK11_DANRESi:ch211-212g7.6. (436 aa)
sptlc2bSerine palmitoyltransferase, long chain base subunit 2b. (558 aa)
ugt8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa)
smpd4Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. (791 aa)
sptlc2aSerine palmitoyltransferase, long chain base subunit 2a. (558 aa)
degs2Delta(4)-desaturase, sphingolipid 2. (322 aa)
sgpp1Sphingosine-1-phosphate phosphatase 1. (423 aa)
acer3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (265 aa)
sgms1Sphingomyelin synthase 1. (404 aa)
cerkCeramide kinase. (649 aa)
sgms2aSphingomyelin synthase 2a. (351 aa)
asah2Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...] (743 aa)
ormdl2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
F1QKZ9_DANRESi:dkey-235d18.5. (761 aa)
acer1Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. May also hydrolyze dihydroceramides to produce dihydrosphingosine. (287 aa)
zgc:91976Zgc:91976. (419 aa)
loxl5bLysyl oxidase-like 5b. (445 aa)
sptlc1Serine palmitoyltransferase, long chain base subunit 1. (484 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (675 aa)
sptssbSerine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSB subfamily. (80 aa)
sphk2Sphingosine kinase 2. (869 aa)
SPHK1Sphingosine kinase 1. (342 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
smpd3Sphingomyelin phosphodiesterase 3. (684 aa)
cers3aCeramide synthase 3a. (380 aa)
sptlc3Serine palmitoyltransferase, long chain base subunit 3. (553 aa)
golga7bbGolgin A7 family, member Bb. (166 aa)
cers2bCeramide synthase 2b. (383 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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