(58 nodes) Mostly uncharacterized, incl. Melatonin metabolic process, and CECR6/TMEM121 family network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	aanat2	Arylalkylamine N-acetyltransferase 2. (209 aa)
	nsd2	Nuclear receptor-binding SET domain protein 2. (1461 aa)
	asmtl	Acetylserotonin O-methyltransferase-like. (632 aa)
	larp1b	La ribonucleoprotein 1B. (1076 aa)
	igfbp2b	Insulin-like growth factor-binding protein 2-B; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (265 aa)
	fgf12a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (241 aa)
	aanat1	Arylalkylamine N-acetyltransferase 1. (204 aa)
	nenf	Neudesin neurotrophic factor; Belongs to the cytochrome b5 family. (188 aa)
	foxp1b	Forkhead box protein P1-B; Transcriptional repressor. (659 aa)
	phpt1	Phosphohistidine phosphatase 1. (121 aa)
	zgc:113054	Zgc:113054. (551 aa)
	htr1fb	5-hydroxytryptamine (serotonin) receptor 1Fb. (372 aa)
	mtnr1ba	Melatonin receptor type 1B-A; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (355 aa)
	letm1	Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). (757 aa)
	frmd4bb	FERM domain-containing 4Bb. (999 aa)
	asmt2	Acetylserotonin O-methyltransferase 2. (348 aa)
	mxra8b	Matrix-remodelling-associated 8b. (434 aa)
	mxra8a	Matrix-remodelling-associated 8a. (447 aa)
	tmem264	Transmembrane protein 264. (328 aa)
	mrpl30	Mitochondrial ribosomal protein L30. (154 aa)
	evi5a	Ecotropic viral integration site 5a. (607 aa)
	E7FE04_DANRE	Si:ch211-267e7.3. (963 aa)
	C7H4orf48	Si:dkeyp-75h12.5. (85 aa)
	foxp1a	Forkhead box P1a. (637 aa)
	tmem121ab	Transmembrane protein 121Ab. (317 aa)
	skor2	SKI family transcriptional corepressor 2. (255 aa)
	crlf2	Fibronectin type-III domain-containing protein. (259 aa)
	cdc37l1	Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. (344 aa)
	mitd1	MIT, microtubule-interacting and transport, domain-containing 1. (246 aa)
	sertad4	SERTA domain-containing 4. (337 aa)
	eevs	2-epi-5-epi-valiolone synthase. (470 aa)
	igflr1	IGF-like family receptor 1. (338 aa)
	nubp2	Cytosolic Fe-S cluster assembly factor nubp2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (269 aa)
	irgf1	Immunity-related GTPase family, f1. (398 aa)
	MDFIC	Si:ch211-262n1.4. (257 aa)
	il7r	Interleukin 7 receptor. (372 aa)
	zgc:101040	Zgc:101040; Belongs to the arylamine N-acetyltransferase family. (290 aa)
	cdc42se2	CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly; Belongs to the CDC42SE/SPEC family. (85 aa)
	cxcl11.8	Chemokine (C-X-C motif) ligand 11, duplicate 8. (102 aa)
	mtnr1al	Melatonin receptor type 1A-like; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	E7FAM7_DANRE	Si:dkey-78a14.4; Belongs to the arylamine N-acetyltransferase family. (288 aa)
	tmem265	Transmembrane protein 265. (345 aa)
	cdca4	Cell division cycle-associated 4. (286 aa)
	frmd4ba	FERM domain-containing 4Ba. (962 aa)
	MDFIC2	Si:dkey-58f6.2. (168 aa)
	fgfbp3	Fibroblast growth factor-binding protein 3. (239 aa)
	gtpbp6	GTP-binding protein 6 (putative). (543 aa)
	tmem121aa	Transmembrane protein 121Aa. (316 aa)
	ahsa1b	AHA1, activator of heat shock protein ATPase homolog 1b. (338 aa)
	SH3RF3	Si:ch211-124n19.2. (602 aa)
	akap17a	A kinase (PRKA) anchor protein 17A. (531 aa)
	lygl2	Lysozyme g. (191 aa)
	asmt	Acetylserotonin O-methyltransferase. (344 aa)
	ENSDARP00000146531	Si:ch211-239f4.1. (839 aa)
	dhrsx	Dehydrogenase/reductase (SDR family) X-linked. (324 aa)
	ENSDARP00000152115	Uncharacterized protein. (109 aa)
	ENSDARP00000152954	Uncharacterized protein. (85 aa)
	zgc:66433	Zgc:66433. (998 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E7FAM7_DANRE	aanat2	ENSDARP00000124562	ENSDARP00000002650	Si:dkey-78a14.4; Belongs to the arylamine N-acetyltransferase family.	Arylalkylamine N-acetyltransferase 2.	0.462
E7FAM7_DANRE	zgc:101040	ENSDARP00000124562	ENSDARP00000121132	Si:dkey-78a14.4; Belongs to the arylamine N-acetyltransferase family.	Zgc:101040; Belongs to the arylamine N-acetyltransferase family.	0.901
ENSDARP00000146531	akap17a	ENSDARP00000146531	ENSDARP00000133964	Si:ch211-239f4.1.	A kinase (PRKA) anchor protein 17A.	0.468
ENSDARP00000146531	mrpl30	ENSDARP00000146531	ENSDARP00000092761	Si:ch211-239f4.1.	Mitochondrial ribosomal protein L30.	0.473
MDFIC	aanat1	ENSDARP00000118467	ENSDARP00000053125	Si:ch211-262n1.4.	Arylalkylamine N-acetyltransferase 1.	0.480
MDFIC	aanat2	ENSDARP00000118467	ENSDARP00000002650	Si:ch211-262n1.4.	Arylalkylamine N-acetyltransferase 2.	0.491
MDFIC	eevs	ENSDARP00000118467	ENSDARP00000111904	Si:ch211-262n1.4.	2-epi-5-epi-valiolone synthase.	0.745
MDFIC	fgfbp3	ENSDARP00000118467	ENSDARP00000128356	Si:ch211-262n1.4.	Fibroblast growth factor-binding protein 3.	0.453
MDFIC	foxp1b	ENSDARP00000118467	ENSDARP00000064937	Si:ch211-262n1.4.	Forkhead box protein P1-B; Transcriptional repressor.	0.574
MDFIC	frmd4ba	ENSDARP00000118467	ENSDARP00000127557	Si:ch211-262n1.4.	FERM domain-containing 4Ba.	0.416
MDFIC	frmd4bb	ENSDARP00000118467	ENSDARP00000078808	Si:ch211-262n1.4.	FERM domain-containing 4Bb.	0.416
MDFIC	igfbp2b	ENSDARP00000118467	ENSDARP00000019643	Si:ch211-262n1.4.	Insulin-like growth factor-binding protein 2-B; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	0.570
MDFIC	igflr1	ENSDARP00000118467	ENSDARP00000111941	Si:ch211-262n1.4.	IGF-like family receptor 1.	0.544
MDFIC	zgc:113054	ENSDARP00000118467	ENSDARP00000070003	Si:ch211-262n1.4.	Zgc:113054.	0.909
MDFIC2	aanat2	ENSDARP00000128012	ENSDARP00000002650	Si:dkey-58f6.2.	Arylalkylamine N-acetyltransferase 2.	0.456
MDFIC2	eevs	ENSDARP00000128012	ENSDARP00000111904	Si:dkey-58f6.2.	2-epi-5-epi-valiolone synthase.	0.733
MDFIC2	fgf12a	ENSDARP00000128012	ENSDARP00000036436	Si:dkey-58f6.2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.480
MDFIC2	fgfbp3	ENSDARP00000128012	ENSDARP00000128356	Si:dkey-58f6.2.	Fibroblast growth factor-binding protein 3.	0.645
MDFIC2	foxp1a	ENSDARP00000128012	ENSDARP00000107924	Si:dkey-58f6.2.	Forkhead box P1a.	0.713
MDFIC2	igfbp2b	ENSDARP00000128012	ENSDARP00000019643	Si:dkey-58f6.2.	Insulin-like growth factor-binding protein 2-B; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	0.744

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