STRINGSTRING
psmb9a psmb9a psma6a psma6a psma8 psma8 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 skp1 skp1 ppp2r5ea ppp2r5ea ppp2r1bb ppp2r1bb ppp2r5a ppp2r5a psmd11b psmd11b psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 gsk3ba gsk3ba UBB UBB psmc4 psmc4 psmb2 psmb2 ppp2ca ppp2ca psme2 psme2 psmc6 psmc6 rbx1 rbx1 gbp gbp psma2 psma2 psmc1b psmc1b psma4 psma4 ppp2r5b ppp2r5b psmd14 psmd14 zranb1b zranb1b psmb11b psmb11b tcf7l1a tcf7l1a psmb10 psmb10 ppp2r5eb ppp2r5eb psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 amer1 amer1 ppp2r5cb ppp2r5cb psmd12 psmd12 csnk1a1 csnk1a1 psma3 psma3 cul1a cul1a ppp2r5d ppp2r5d lef1 lef1 ppp2r1ba ppp2r1ba tle2a tle2a psmb4 psmb4 psmd5 psmd5 tle2b tle2b psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 tcf7 tcf7 rps27a rps27a CTBP1 CTBP1 psmf1 psmf1 psma1 psma1 axin1 axin1 psmd4a psmd4a ctnnb1 ctnnb1 apc apc ubc ubc ppp2cb ppp2cb ubb ubb tle3b tle3b psmd1 psmd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
ppp2r5eaSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (468 aa)
ppp2r1bbProtein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform. (589 aa)
ppp2r5aSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (477 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
UBBSi:ch211-202a12.4. (459 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmb2Proteasome subunit beta. (199 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
gbpGlycogen synthase kinase-binding protein. (149 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
ppp2r5bSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (503 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
zranb1bUbiquitin thioesterase zranb1-B; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). (716 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
tcf7l1aTranscription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa)
psmb10Proteasome subunit beta. (276 aa)
ppp2r5ebSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
amer1APC membrane recruitment protein 1; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context (By similarity); Belongs to the Amer family. (953 aa)
ppp2r5cbSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (578 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
csnk1a1Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa)
psma3Proteasome subunit alpha type. (255 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
ppp2r5dProtein phosphatase 2, regulatory subunit B', delta. (631 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
ppp2r1baProtein phosphatase 2, regulatory subunit A, beta a. (589 aa)
tle2aTLE family member 2, transcriptional corepressor a. (811 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
tle2bTLE family member 2, transcriptional corepressor b. (766 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
tcf7Transcription factor 7. (355 aa)
rps27aRibosomal protein S27a. (156 aa)
CTBP1Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
ubcUbiquitin C. (533 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ubbUbiquitin B. (610 aa)
tle3bTransducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family. (771 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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