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| | nckipsd | NCK-interacting protein with SH3 domain. (759 aa) |
| | R4GE02_DANRE | Si:ch211-113a14.11; Belongs to the histone H2A family. (248 aa) |
| | R4GE15_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | bub3 | BUB3 mitotic checkpoint protein. (338 aa) |
| | mrtfab | Myocardin-related transcription factor Ab. (1200 aa) |
| | X1WDH8_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ahctf1 | AT hook-containing transcription factor 1. (2527 aa) |
| | X1WGM0_DANRE | Si:dkey-148h10.5. (152 aa) |
| | cenpo | Centromere protein O. (322 aa) |
| | X1WH60_DANRE | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | X1WHF1_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ppp1cbl | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (231 aa) |
| | nup85 | Nuclear pore complex protein Nup85; Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity). (412 aa) |
| | iqgap3 | IQ motif-containing GTPase-activating protein 3. (1639 aa) |
| | spdl1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (590 aa) |
| | pak1 | Non-specific serine/threonine protein kinase. (587 aa) |
| | ENSDARP00000132715 | WD_REPEATS_REGION domain-containing protein. (504 aa) |
| | limk1a | LIM domain kinase 1a. (648 aa) |
| | ctnna1 | Catenin (cadherin-associated protein), alpha 1. (907 aa) |
| | nde1 | NudE neurodevelopment protein 1. (336 aa) |
| | kntc1 | Kinetochore-associated 1. (2290 aa) |
| | pin1 | Peptidyl-prolyl cis-trans isomerase. (141 aa) |
| | ENSDARP00000135395 | Si:ch73-340n8.4. (162 aa) |
| | nudc | NudC nuclear distribution protein. (333 aa) |
| | sgo1 | Shugoshin 1. (616 aa) |
| | pak2a | Non-specific serine/threonine protein kinase. (518 aa) |
| | myl12.1 | Myosin, light chain 12, genome duplicate 1. (172 aa) |
| | h2af1al | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | taok1b | TAO kinase 1b. (1001 aa) |
| | incenp | Uncharacterized protein. (815 aa) |
| | dync1li1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (501 aa) |
| | kif5aa | Kinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1033 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | ndel1b | Nuclear distribution protein nudE-like 1-B; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity). (344 aa) |
| | ENSDARP00000140159 | Si:dkey-225f5.4. (378 aa) |
| | ppp2cb | Serine/threonine-protein phosphatase. (309 aa) |
| | cdc20 | Cell division cycle 20 homolog. (496 aa) |
| | rock1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa) |
| | dvl3 | Dishevelled segment polarity protein 3b. (706 aa) |
| | ppp1cc | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa) |
| | hist1h2a6 | Histone H2A; Belongs to the histone H2A family. (127 aa) |
| | ENSDARP00000142232 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSDARP00000142451 | Histone H2A; Belongs to the histone H2A family. (127 aa) |
| | cdca8 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). (276 aa) |
| | scai | Suppressor of cancer cell invasion. (608 aa) |
| | nup160 | Nucleoporin 160. (1171 aa) |
| | PKN2 | Serine/threonine-protein kinase N2; Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). (984 aa) |
| | wasf1 | WASP family member 1. (498 aa) |
| | xpo1b | Exportin 1 (CRM1 homolog, yeast) b. (1081 aa) |
| | nup37 | Nucleoporin 37. (326 aa) |
| | pkn2 | Serine/threonine-protein kinase N2. (1005 aa) |
| | rhoac | Rho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | RANBP2 | Si:ch1073-55a19.2. (2953 aa) |
| | cenpa | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] (145 aa) |
| | ska2 | Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] (226 aa) |
| | prkcaa | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
| | nckap1 | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). (1134 aa) |
| | rhocb | Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | seh1l | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (364 aa) |
| | cdc25b | Cell division cycle 25B. (563 aa) |
| | mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa) |
| | rcc2 | Protein RCC2 homolog; Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton [...] (495 aa) |
| | arpc1a | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa) |
| | b9d2 | B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. (175 aa) |
| | ywhah | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa) |
| | dync1i2a | Dynein, cytoplasmic 1, intermediate chain 2a; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Plays a role in the development of anterior brain and cartilaginous structures. Belongs to the dynein intermediate chain family. (626 aa) |
| | mapre1b | Microtubule-associated protein, RP/EB family, member 1b. (258 aa) |
| | klc1a | Kinesin light chain 1a. (605 aa) |
| | ndc80 | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (632 aa) |
| | ercc6l | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). (1451 aa) |
| | cyba | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (185 aa) |
| | dynll2b | Dynein light chain. (89 aa) |
| | ppp2r5ea | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (468 aa) |
| | ppp2r1bb | Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform. (589 aa) |
| | pdpk1b | 3-phosphoinositide-dependent protein kinase 1b. (537 aa) |
| | ppp2r5a | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (477 aa) |
| | zw10 | Zw10 kinetochore protein. (771 aa) |
| | ppp1r14aa | Protein phosphatase 1, regulatory (inhibitor) subunit 14Aa. (152 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | ywhaqb | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa) |
| | kif18a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (895 aa) |
| | nup133 | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport (By similarity). Involved in nephrogenesis. (1136 aa) |
| | rhpn2 | Rhophilin-2; Binds specifically to GTP-Rho. (683 aa) |
| | arpc5b | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa) |
| | daam1b | Dishevelled-associated activator of morphogenesis 1b. (1079 aa) |
| | rhogb | Ras homolog gene family, member Gb. (191 aa) |
| | nsl1 | NSL1 component of MIS12 kinetochore complex. (238 aa) |
| | dync1li2 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (500 aa) |
| | rhoq | Ras homolog gene family, member Q. (205 aa) |
| | mis12 | MIS12 kinetochore complex component. (215 aa) |
| | ywhae1 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa) |
| | prkcda | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa) |
| | mapk11 | Mitogen-activated protein kinase. (361 aa) |
| | mapk14b | Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | pane1 | Centromere protein M; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (186 aa) |
| | arpc1b | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa) |
| | mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa) |
| | prkcbb | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa) |
| | pafah1b1b | Lissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa) |
| | nup107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (919 aa) |
| | h2ax | Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] (142 aa) |
| | mapk14a | Mitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | rhoaa | Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | nuf2 | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (454 aa) |
| | myh11a | Myosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa) |
| | pafah1b1a | Lissencephaly-1 homolog A; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa) |
| | ppp2ca | Serine/threonine-protein phosphatase. (309 aa) |
| | srgap2 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. May play a role in different aspects of neuronal morphogenesis and migration. This includes the biogenesis of neurites, where it could be required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. May also stimulate the branching of the leading process and negatively regulates neuron migration. In non-neuronal cells, it may also play a role in cell migration by reg [...] (1100 aa) |
| | mylka | Myosin, light chain kinase a. (899 aa) |
| | ncf1 | Neutrophil cytosolic factor 1. (410 aa) |
| | pfn2l | Profilin; Belongs to the profilin family. (139 aa) |
| | aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (320 aa) |
| | actb1 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | hist2h2l | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | s100z | Protein S100; Belongs to the S-100 family. (99 aa) |
| | cenpl | Centromere protein L; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-L/IML3 family. (351 aa) |
| | ska1 | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] (258 aa) |
| | spc24 | Kinetochore protein Spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (202 aa) |
| | ncf4 | Neutrophil cytosolic factor 4. (355 aa) |
| | cftr | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa) |
| | gopc | Golgi-associated PDZ and coiled-coil motif-containing. (455 aa) |
| | brk1 | Probable protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity); Belongs to the BRK1 family. (83 aa) |
| | ywhaqa | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (245 aa) |
| | prkcz | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa) |
| | cenpn | Centromere protein N. (345 aa) |
| | nup43 | Nucleoporin 43. (372 aa) |
| | cenpp | Centromere protein P; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-P/CTF19 family. (282 aa) |
| | cyfip1 | Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family. (1253 aa) |
| | hist1h2a1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | hist1h2a4 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | zgc:173552 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | zgc:194989 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | actr2a | Actin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa) |
| | cenpi | Centromere protein I. (732 aa) |
| | RTKN | Si:dkey-40c11.1. (630 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | rhof | Ras homolog gene family, member F. (209 aa) |
| | ppp2r5b | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (503 aa) |
| | rps27.2 | 40S ribosomal protein S27. (84 aa) |
| | klc3 | Kinesin light chain 3. (512 aa) |
| | noxa1 | NADPH oxidase activator 1. (269 aa) |
| | noxo1b | NADPH oxidase organizer 1b. (477 aa) |
| | zwilch | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). (583 aa) |
| | arpc3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | dynll1 | Dynein light chain. (89 aa) |
| | plk1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | F1R963_DANRE | Si:dkey-30c15.12; Cadherins are calcium-dependent cell adhesion proteins. (737 aa) |
| | tax1bp3 | Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (125 aa) |
| | pik3r4 | Phosphoinositide-3-kinase, regulatory subunit 4. (1347 aa) |
| | KIF2A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (719 aa) |
| | nox1 | NADPH oxidase 1. (564 aa) |
| | NCKAP1L | Zgc:172352. (1123 aa) |
| | kdm4c | Lysine (K)-specific demethylase 4C. (1482 aa) |
| | rangap1a | RAN GTPase-activating protein 1a. (570 aa) |
| | kif14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1506 aa) |
| | zgc:113983 | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | myh9b | Myosin, heavy chain 9b, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1749 aa) |
| | ar | Androgen receptor. (868 aa) |
| | h3f3a-2 | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | ncf2 | Neutrophil cytosolic factor 2. (500 aa) |
| | h2az2a | Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (128 aa) |
| | arpc2 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa) |
| | hist1h2a10 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | h2ax1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | ppp2r5eb | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa) |
| | pik3c3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa) |
| | clasp1a | Cytoplasmic linker-associated protein 1a. (1535 aa) |
| | actr2b | Actin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa) |
| | src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa) |
| | hist1h2a3 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | cenps | Similar to apoptosis-inducing, TAF9-like domain 1. (127 aa) |
| | wasla | WASP-like actin nucleation-promoting factor a. (502 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | dvl1b | Dishevelled segment polarity protein 1b. (716 aa) |
| | ywhag2 | 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa) |
| | rac1a | Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa) |
| | iqgap1 | IQ motif-containing GTPase-activating protein 1. (1655 aa) |
| | clip1a | CAP-GLY domain-containing linker protein 1a. (1569 aa) |
| | cenpe | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2690 aa) |
| | zgc:173585 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | fmnl3 | Formin-like protein 3; Required for developmental angiogenesis, but not for vasculogenesis; Belongs to the formin homology family. (1047 aa) |
| | ywhabb | 14-3-3 protein beta/alpha-B; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (242 aa) |
| | zgc:173587 | Histone H2B 1/2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | bub1ba | BUB1 mitotic checkpoint serine/threonine kinase Ba. (722 aa) |
| | kif2c | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (700 aa) |
| | si:dkey-6i22.5 | Si:dkey-6i22.5. (219 aa) |
| | pkn3 | Protein kinase N3. (940 aa) |
| | ppp2r5cb | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (578 aa) |
| | kif5ba | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (968 aa) |
| | wasf2 | WASP family member 2. (486 aa) |
| | myl9b | Myosin, light polypeptide 9, regulatory. (173 aa) |
| | hist1h2a5 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | spc25 | SPC25 component of NDC80 kinetochore complex. (234 aa) |
| | LOC100148591 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | dsn1 | DSN1 component of MIS12 kinetochore complex. (330 aa) |
| | E7FCV0_DANRE | Si:dkey-185e18.7. (397 aa) |
| | rac2 | Rac family small GTPase 2. (219 aa) |
| | ktn1 | Kinectin 1. (1262 aa) |
| | ncoa2 | Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity). (1505 aa) |
| | cita | Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2344 aa) |
| | pfn1 | Profilin; Belongs to the profilin family. (141 aa) |
| | E7FAC3_DANRE | Si:ch211-161h7.4. (1130 aa) |
| | nup98 | Nucleoporin 98. (1814 aa) |
| | lin7b | Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (220 aa) |
| | ppp2r5d | Protein phosphatase 2, regulatory subunit B', delta. (631 aa) |
| | flna | Filamin A, alpha (actin-binding protein 280). (2553 aa) |
| | myh14 | Myosin, heavy chain 14, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2020 aa) |
| | prc1b | Protein regulator of cytokinesis 1b. (606 aa) |
| | cenpf | Centromere protein F. (2708 aa) |
| | arpc4 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (193 aa) |
| | ppp2r1ba | Protein phosphatase 2, regulatory subunit A, beta a. (589 aa) |
| | clasp2 | CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar [...] (1476 aa) |
| | bub1 | BUB1 mitotic checkpoint serine/threonine kinase. (1202 aa) |
| | B0UYN0_DANRE | Si:dkey-57a22.11. (847 aa) |
| | myl12.2 | Myosin, light chain 12, genome duplicate 2. (172 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | zgc:92591 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | knl1 | Kinetochore scaffold 1. (1794 aa) |
| | nf2a | Similar to neurofibromin 2. (593 aa) |
| | cenpt | Si:ch211-225g23.1. (914 aa) |
| | nck1b | Cytoplasmic protein. (381 aa) |
| | rhpn1 | Rhophilin, Rho GTPase-binding protein 1. (658 aa) |
| | iqgap2 | IQ motif-containing GTPase-activating protein 2. (1680 aa) |
| | actb2 | Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | grb2b | Growth factor receptor-bound protein 2b. (217 aa) |
| | diaph3 | Diaphanous-related formin 3. (1078 aa) |
| | mad1l1 | Mitotic arrest deficient-like protein 1. (717 aa) |
| | pkn1a | Protein kinase N1a. (930 aa) |
| | cenph | Centromere protein H. (233 aa) |
| | cdc42l2 | Cell division cycle 42-like 2. (209 aa) |
| | cenpk | Centromere protein K. (275 aa) |
| | abl1 | Tyrosine-protein kinase. (1081 aa) |
| | men1 | Multiple endocrine neoplasia I. (617 aa) |
| | wipf1b | WAS/WASL-interacting protein family, member 1b. (485 aa) |
| | myh10 | Myosin, heavy chain 10, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1992 aa) |
| | fmnl1a | Formin-like 1a. (1085 aa) |
