STRINGSTRING
psmb9a psmb9a psma6a psma6a psma8 psma8 sel1l sel1l psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 vcp vcp psme1 psme1 psmb3 psmb3 abcc9 abcc9 erlin1 erlin1 psmd11b psmd11b pex3 pex3 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 eif2s3 eif2s3 UBB UBB psmc4 psmc4 derl1 derl1 psmb2 psmb2 pex19 pex19 rnf185 rnf185 abcb11a abcb11a abcf1 abcf1 psme2 psme2 psmc6 psmc6 psma2 psma2 cftr cftr derl2 derl2 psmc1b psmc1b abcc6a abcc6a psma4 psma4 kcnj11 kcnj11 eif2s1b eif2s1b eif2s2 eif2s2 abcb9 abcb9 abcb8 abcb8 abcc5 abcc5 abcb7 abcb7 abcg5 abcg5 psmd14 psmd14 abcb6a abcb6a abcg1 abcg1 psmb11b psmb11b psmb10 psmb10 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 RNF5 RNF5 abcd1 abcd1 abcc10 abcc10 erlec1 erlec1 psmd12 psmd12 psma3 psma3 abcg4a abcg4a psmb4 psmb4 os9 os9 abca12 abca12 erlin2 erlin2 psmd5 psmd5 abca4a abca4a abcc12 abcc12 abcb4 abcb4 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 abca5 abca5 rps27a rps27a abcc1 abcc1 psmf1 psmf1 psma1 psma1 psmd4a psmd4a abcd3a abcd3a ubc ubc abcc3 abcc3 ubb ubb psmd1 psmd1 abca3b abca3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
sel1lSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (776 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 9. (1558 aa)
erlin1Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. (342 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
pex3Peroxisomal biogenesis factor 3. (364 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
eif2s3Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] (472 aa)
UBBSi:ch211-202a12.4. (459 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
derl1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (261 aa)
psmb2Proteasome subunit beta. (199 aa)
pex19Peroxisomal biogenesis factor 19. (288 aa)
rnf185E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] (194 aa)
abcb11aATP-binding cassette, sub-family B (MDR/TAP), member 11a. (1320 aa)
abcf1ATP-binding cassette, sub-family F (GCN20), member 1. (877 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
psma2Proteasome subunit alpha type. (234 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
derl2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
abcc6aATP-binding cassette, sub-family C (CFTR/MRP), member 6a. (1507 aa)
psma4Proteasome subunit alpha type. (261 aa)
kcnj11Potassium inwardly-rectifying channel, subfamily J, member 11. (381 aa)
eif2s1bEukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
eif2s2Eukaryotic translation initiation factor 2, subunit 2 beta. (327 aa)
abcb9ATP-binding cassette, sub-family B (MDR/TAP), member 9. (789 aa)
abcb8Mitochondrial potassium channel ATP-binding subunit; ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (B [...] (714 aa)
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 5. (1426 aa)
abcb7ATP-binding cassette, sub-family B (MDR/TAP), member 7. (743 aa)
abcg5ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
abcb6aATP-binding cassette, sub-family B (MDR/TAP), member 6a. (851 aa)
abcg1ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
psmb10Proteasome subunit beta. (276 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
RNF5Ring finger protein 5. (192 aa)
abcd1ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa)
abcc10ATP-binding cassette, sub-family C (CFTR/MRP), member 10. (1548 aa)
erlec1Endoplasmic reticulum lectin 1. (425 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
abcg4aATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
os9OS9 endoplasmic reticulum lectin. (703 aa)
abca12ATP-binding cassette, sub-family A (ABC1), member 12. (1809 aa)
erlin2Erlin-2; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity); Belongs to the band 7/mec-2 family. (331 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
abca4aATP-binding cassette, sub-family A (ABC1), member 4a. (2277 aa)
abcc12ATP-binding cassette, sub-family C (CFTR/MRP), member 12. (1368 aa)
abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 4. (1275 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
abca5ATP-binding cassette, sub-family A (ABC1), member 5. (1673 aa)
rps27aRibosomal protein S27a. (156 aa)
abcc1ATP-binding cassette, sub-family C (CFTR/MRP), member 1. (1518 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
abcd3aATP-binding cassette, sub-family D (ALD), member 3a. (656 aa)
ubcUbiquitin C. (533 aa)
abcc3ATP-binding cassette, sub-family C (CFTR/MRP), member 3. (1538 aa)
ubbUbiquitin B. (610 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
abca3bATP-binding cassette, sub-family A (ABC1), member 3b. (1754 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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