STRINGSTRING
psmb9a psmb9a psma6a psma6a psma8 psma8 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 psmd11b psmd11b dvl2 dvl2 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 UBB UBB psmc4 psmc4 psmb2 psmb2 psme2 psme2 psmc6 psmc6 rbx1 rbx1 psma2 psma2 psmc1b psmc1b psma4 psma4 psmd14 psmd14 psmb11b psmb11b psmb10 psmb10 dvl1b dvl1b psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 psmd12 psmd12 psma3 psma3 hecw1b hecw1b psmb4 psmb4 psmd5 psmd5 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 rps27a rps27a klhl12 klhl12 cul3b cul3b dact1 dact1 psmf1 psmf1 psma1 psma1 psmd4a psmd4a ubc ubc ubb ubb dvl3 dvl3 KLHL12 KLHL12 psmd1 psmd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
UBBSi:ch211-202a12.4. (459 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmb2Proteasome subunit beta. (199 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
psmb10Proteasome subunit beta. (276 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
hecw1bHECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1b. (1552 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
rps27aRibosomal protein S27a. (156 aa)
klhl12Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3. Regulates convergent-extension movements during early [...] (314 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
dact1Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to activate the canonical Wnt signaling pathway. (616 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
dvl3Dishevelled segment polarity protein 3b. (706 aa)
KLHL12Kelch like family member 12. (255 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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