STRINGSTRING
psmb9a psmb9a fzr1a fzr1a mcm3 mcm3 psma6a psma6a cdc6 cdc6 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 mcm5 mcm5 psmd11b psmd11b mcm6 mcm6 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 UBB UBB orc5 orc5 ube2d1b ube2d1b psmc4 psmc4 h2ax h2ax psmb2 psmb2 ube2s ube2s orc3 orc3 psme2 psme2 ube2e2 ube2e2 gmnn gmnn psmc6 psmc6 hist2h2l hist2h2l anapc4 anapc4 mcm4 mcm4 psma2 psma2 psmc1b psmc1b cdc23 cdc23 kpna6 kpna6 psma4 psma4 hist1h2a1 hist1h2a1 hist1h2a4 hist1h2a4 zgc:173552 zgc:173552 zgc:194989 zgc:194989 cdc16 cdc16 zgc:113983 zgc:113983 anapc7 anapc7 psmd14 psmd14 cdt1 cdt1 h3f3a-2 h3f3a-2 h2az2a h2az2a hist1h2a10 hist1h2a10 psmb10 psmb10 h2ax1 h2ax1 hist1h2a3 hist1h2a3 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 zgc:173585 zgc:173585 cdc26 cdc26 orc6 orc6 zgc:173587 zgc:173587 hist1h2a5 hist1h2a5 LOC100148591 LOC100148591 psmd12 psmd12 anapc16 anapc16 psma3 psma3 cdc27 cdc27 psmb4 psmb4 zgc:92591 zgc:92591 kpna1 kpna1 psmd5 psmd5 anapc10 anapc10 R4GE02_DANRE R4GE02_DANRE R4GE15_DANRE R4GE15_DANRE si:rp71-45k5.4 si:rp71-45k5.4 mcm8 mcm8 X1WDH8_DANRE X1WDH8_DANRE rps27a rps27a X1WH60_DANRE X1WH60_DANRE X1WHF1_DANRE X1WHF1_DANRE anapc11 anapc11 orc4 orc4 orc2 orc2 anapc5 anapc5 mcm7 mcm7 mcm2 mcm2 psmf1 psmf1 psma1 psma1 ENSDARP00000135395 ENSDARP00000135395 kpnb1 kpnb1 h2af1al h2af1al psmd4a psmd4a anapc2 anapc2 ubc ubc ubb ubb hist1h2a6 hist1h2a6 ENSDARP00000142232 ENSDARP00000142232 ENSDARP00000142451 ENSDARP00000142451 psmd1 psmd1 anapc1 anapc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
fzr1aFizzy/cell division cycle 20 related 1 (Drosophila). (495 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
psma6aProteasome subunit alpha type. (246 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
mcm5DNA helicase; Belongs to the MCM family. (736 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
mcm6DNA helicase; Belongs to the MCM family. (830 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
UBBSi:ch211-202a12.4. (459 aa)
orc5Origin recognition complex, subunit 5-like (Yeast). (444 aa)
ube2d1bUbiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
h2axHistone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] (142 aa)
psmb2Proteasome subunit beta. (199 aa)
ube2sUbiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (221 aa)
orc3Origin recognition complex, subunit 3. (706 aa)
psme2Proteasome activator subunit 2. (244 aa)
ube2e2Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
gmnnGeminin DNA replication inhibitor. (241 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (797 aa)
mcm4DNA helicase; Belongs to the MCM family. (845 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
cdc23CDC23 (Cell division cycle 23, yeast, homolog). (579 aa)
kpna6Importin subunit alpha; Belongs to the importin alpha family. (537 aa)
psma4Proteasome subunit alpha type. (261 aa)
hist1h2a1Histone H2A; Belongs to the histone H2A family. (128 aa)
hist1h2a4Histone H2A; Belongs to the histone H2A family. (128 aa)
zgc:173552Histone H3; Belongs to the histone H3 family. (136 aa)
zgc:194989Histone H2B; Belongs to the histone H2B family. (124 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (616 aa)
zgc:113983Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
anapc7Anaphase-promoting complex subunit 7. (566 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
cdt1Chromatin licensing and DNA replication factor 1. (678 aa)
h3f3a-2Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
h2az2aHistone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (128 aa)
hist1h2a10Histone H2A; Belongs to the histone H2A family. (128 aa)
psmb10Proteasome subunit beta. (276 aa)
h2ax1Histone H2A; Belongs to the histone H2A family. (128 aa)
hist1h2a3Histone H2A; Belongs to the histone H2A family. (128 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
zgc:173585Histone H2B; Belongs to the histone H2B family. (124 aa)
cdc26Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex; Belongs to the CDC26 [...] (88 aa)
orc6Origin recognition complex, subunit 6 homolog-like (Yeast). (256 aa)
zgc:173587Histone H2B 1/2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
hist1h2a5Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC100148591Histone H2A; Belongs to the histone H2A family. (128 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
anapc16Anaphase-promoting complex subunit 16. (108 aa)
psma3Proteasome subunit alpha type. (255 aa)
cdc27Cell division cycle 27. (833 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
zgc:92591Histone H2B; Belongs to the histone H2B family. (118 aa)
kpna1Karyopherin alpha 1 (importin alpha 5). (589 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
R4GE02_DANRESi:ch211-113a14.11; Belongs to the histone H2A family. (248 aa)
R4GE15_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
X1WDH8_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
rps27aRibosomal protein S27a. (156 aa)
X1WH60_DANREHistone H2B; Belongs to the histone H2B family. (125 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
anapc11APC11 anaphase-promoting complex subunit 11 homolog (yeast). (88 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
orc2Origin recognition complex, subunit 2. (552 aa)
anapc5Anaphase-promoting complex subunit 5. (718 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (608 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
ENSDARP00000135395Si:ch73-340n8.4. (162 aa)
kpnb1Karyopherin (importin) beta 1. (876 aa)
h2af1alHistone H2A; Belongs to the histone H2A family. (140 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (802 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
hist1h2a6Histone H2A; Belongs to the histone H2A family. (127 aa)
ENSDARP00000142232Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSDARP00000142451Histone H2A; Belongs to the histone H2A family. (127 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
anapc1Anaphase-promoting complex subunit 1. (1932 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (42%) [HD]