STRINGSTRING
cdc6 cdc6 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 skp1 skp1 mcm5 mcm5 psmd11b psmd11b ccna1 ccna1 mcm6 mcm6 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 UBB UBB cdk2 cdk2 orc5 orc5 psmc4 psmc4 psmb2 psmb2 orc3 orc3 psme2 psme2 psmc6 psmc6 rbx1 rbx1 mcm4 mcm4 psma2 psma2 psmc1b psmc1b psma4 psma4 psmd14 psmd14 mcm3 mcm3 psmb11b psmb11b cdt1 cdt1 psmb10 psmb10 skp2 skp2 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 orc6 orc6 psma6a psma6a psmd12 psmd12 psma3 psma3 psmb9a psmb9a cul1a cul1a psmb4 psmb4 psmd5 psmd5 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 mcm8 mcm8 rps27a rps27a orc4 orc4 orc2 orc2 mcm7 mcm7 mcm2 mcm2 psmf1 psmf1 psma1 psma1 psmd4a psmd4a ubc ubc ubb ubb ccna2 ccna2 psmd1 psmd1 psma8 psma8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
mcm5DNA helicase; Belongs to the MCM family. (736 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
mcm6DNA helicase; Belongs to the MCM family. (830 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
UBBSi:ch211-202a12.4. (459 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
orc5Origin recognition complex, subunit 5-like (Yeast). (444 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmb2Proteasome subunit beta. (199 aa)
orc3Origin recognition complex, subunit 3. (706 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
mcm4DNA helicase; Belongs to the MCM family. (845 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
cdt1Chromatin licensing and DNA replication factor 1. (678 aa)
psmb10Proteasome subunit beta. (276 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
orc6Origin recognition complex, subunit 6 homolog-like (Yeast). (256 aa)
psma6aProteasome subunit alpha type. (246 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmb9aProteasome subunit beta. (218 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
rps27aRibosomal protein S27a. (156 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
orc2Origin recognition complex, subunit 2. (552 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (608 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (454 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
psma8Proteasome subunit alpha type. (251 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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