STRINGSTRING
psmb9a psmb9a fzr1a fzr1a psma6a psma6a psma8 psma8 cdc6 cdc6 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 psmd11b psmd11b ccna1 ccna1 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 UBB UBB cdk2 cdk2 ube2d1b ube2d1b psmc4 psmc4 psmb2 psmb2 ube2s ube2s psme2 psme2 ube2e2 ube2e2 psmc6 psmc6 anapc4 anapc4 psma2 psma2 psmc1b psmc1b cdc23 cdc23 psma4 psma4 cdc16 cdc16 anapc7 anapc7 psmd14 psmd14 psmb11b psmb11b psmb10 psmb10 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 cdc26 cdc26 psmd12 psmd12 anapc16 anapc16 psma3 psma3 cdc27 cdc27 psmb4 psmb4 psmd5 psmd5 anapc10 anapc10 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 rps27a rps27a anapc11 anapc11 anapc5 anapc5 psmf1 psmf1 psma1 psma1 psmd4a psmd4a anapc2 anapc2 ubc ubc ubb ubb ccne2 ccne2 ccne1 ccne1 ccna2 ccna2 psmd1 psmd1 anapc1 anapc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
fzr1aFizzy/cell division cycle 20 related 1 (Drosophila). (495 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
UBBSi:ch211-202a12.4. (459 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ube2d1bUbiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmb2Proteasome subunit beta. (199 aa)
ube2sUbiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (221 aa)
psme2Proteasome activator subunit 2. (244 aa)
ube2e2Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (797 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
cdc23CDC23 (Cell division cycle 23, yeast, homolog). (579 aa)
psma4Proteasome subunit alpha type. (261 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (616 aa)
anapc7Anaphase-promoting complex subunit 7. (566 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
psmb10Proteasome subunit beta. (276 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
cdc26Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex; Belongs to the CDC26 [...] (88 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
anapc16Anaphase-promoting complex subunit 16. (108 aa)
psma3Proteasome subunit alpha type. (255 aa)
cdc27Cell division cycle 27. (833 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
rps27aRibosomal protein S27a. (156 aa)
anapc11APC11 anaphase-promoting complex subunit 11 homolog (yeast). (88 aa)
anapc5Anaphase-promoting complex subunit 5. (718 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (802 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (392 aa)
ccne1G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (410 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (454 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
anapc1Anaphase-promoting complex subunit 1. (1932 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.