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| | psmb9a | Proteasome subunit beta. (218 aa) |
| | nsd2 | Nuclear receptor-binding SET domain protein 2. (1461 aa) |
| | cdc25b | Cell division cycle 25B. (563 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (807 aa) |
| | ube2na | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa) |
| | psma6a | Proteasome subunit alpha type. (246 aa) |
| | psma8 | Proteasome subunit alpha type. (251 aa) |
| | ywhah | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa) |
| | psma5 | Proteasome subunit alpha type. (241 aa) |
| | psmd10 | Proteasome 26S subunit, non-ATPase, 10. (226 aa) |
| | psmc2 | Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | psmb1 | Proteasome subunit beta. (237 aa) |
| | psme1 | Proteasome activator subunit 1. (248 aa) |
| | psmb3 | Proteasome subunit beta. (205 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3091 aa) |
| | rpa3 | Replication protein A3. (121 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (736 aa) |
| | psmd11b | 26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (830 aa) |
| | ywhaqb | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa) |
| | psmd8 | Proteasome 26S subunit, non-ATPase 8. (267 aa) |
| | psmb6 | Proteasome subunit beta. (232 aa) |
| | psmd9 | Proteasome 26S subunit, non-ATPase 9. (211 aa) |
| | psmd3 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa) |
| | rpa1 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa) |
| | UBB | Si:ch211-202a12.4. (459 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ywhae1 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa) |
| | orc5 | Origin recognition complex, subunit 5-like (Yeast). (444 aa) |
| | psmc4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | chek2 | Checkpoint kinase 2. (503 aa) |
| | psmb2 | Proteasome subunit beta. (199 aa) |
| | orc3 | Origin recognition complex, subunit 3. (706 aa) |
| | psme2 | Proteasome activator subunit 2. (244 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (334 aa) |
| | ccnb2 | Cyclin B2; Belongs to the cyclin family. (386 aa) |
| | psmc6 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa) |
| | rpa2 | Replication protein A2. (271 aa) |
| | hist2h2l | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | babam2 | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integri [...] (386 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (845 aa) |
| | psma2 | Proteasome subunit alpha type. (234 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity (By similarity). (818 aa) |
| | rad1 | RAD1 homolog (S. pombe). (279 aa) |
| | rmi1 | RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). (519 aa) |
| | ywhaqa | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (245 aa) |
| | ccnb1 | Cyclin B1; Belongs to the cyclin family. (397 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (391 aa) |
| | rbbp8 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. (651 aa) |
| | psmc1b | Proteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa) |
| | dbf4 | DBF4 zinc finger. (612 aa) |
| | mcm10 | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). (833 aa) |
| | ube2nb | Ubiquitin-conjugating enzyme E2N-like; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | psma4 | Proteasome subunit alpha type. (261 aa) |
| | zgc:194989 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | exo1 | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). (806 aa) |
| | atrip | ATR-interacting protein. (737 aa) |
| | psmd14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | psmb11b | Proteasome 20S subunit beta 11b. (362 aa) |
| | psmb10 | Proteasome subunit beta. (276 aa) |
| | h2ax1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | psmd6 | Proteasome 26S subunit, non-ATPase 6. (386 aa) |
| | psmd13 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa) |
| | psmb8a | Proteasome subunit beta. (271 aa) |
| | pias4a | E3 SUMO-protein ligase PIAS4-A; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif. Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15. May inhibit ticam1/trif-mediated activation of NF-kappa-B. (508 aa) |
| | ywhag2 | 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa) |
| | psmc5 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa) |
| | herc2 | HECT and RLD domain-containing E3 ubiquitin protein ligase 2. (4830 aa) |
| | zgc:173585 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | pkmyt1 | Protein kinase, membrane-associated tyrosine/threonine 1. (554 aa) |
| | ywhabb | 14-3-3 protein beta/alpha-B; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (242 aa) |
| | tp53bp1 | Tumor protein p53-binding protein, 1. (1709 aa) |
| | orc6 | Origin recognition complex, subunit 6 homolog-like (Yeast). (256 aa) |
| | zgc:173587 | Histone H2B 1/2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1378 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (384 aa) |
| | wee1 | Wee1-like protein kinase. (612 aa) |
| | mdc1 | Mediator of DNA damage checkpoint 1. (1914 aa) |
| | psmd12 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa) |
| | E7F2N1_DANRE | Si:ch73-352p4.5. (287 aa) |
| | uimc1 | Uncharacterized protein. (524 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] (370 aa) |
| | psma3 | Proteasome subunit alpha type. (255 aa) |
| | cdk1 | Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (666 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | psmb4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | zgc:92591 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | rad9b | Cell cycle checkpoint control protein; Belongs to the rad9 family. (402 aa) |
| | psmd5 | Proteasome 26S subunit, non-ATPase 5. (505 aa) |
| | kat5b | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (538 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | rnf8 | E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] (531 aa) |
| | R4GE02_DANRE | Si:ch211-113a14.11; Belongs to the histone H2A family. (248 aa) |
| | R4GE15_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | psme4b | Proteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa) |
| | si:rp71-45k5.4 | Proteasome subunit alpha type. (234 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (998 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa) |
| | X1WDH8_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | X1WH60_DANRE | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | X1WHF1_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (358 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa) |
| | orc2 | Origin recognition complex, subunit 2. (552 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (608 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (889 aa) |
| | wrn | WRN RecQ-like helicase. (1436 aa) |
| | psmf1 | Proteasome inhibitor subunit 1. (272 aa) |
| | chek1 | CHK1 checkpoint homolog (S. pombe); Belongs to the protein kinase superfamily. (410 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (261 aa) |
| | psma1 | Proteasome subunit alpha type. (262 aa) |
| | ENSDARP00000135395 | Si:ch73-340n8.4. (162 aa) |
| | h2af1al | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | psmd4a | Proteasome 26S subunit, non-ATPase 4a. (372 aa) |
| | mre11a | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (700 aa) |
| | ubc | Ubiquitin C. (533 aa) |
| | rmi2 | RecQ mediated genome instability 2. (149 aa) |
| | ubb | Ubiquitin B. (610 aa) |
| | ENSDARP00000142232 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | psmd1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa) |
| | blm | BLM RecQ-like helicase. (1439 aa) |
| | topbp1 | DNA topoisomerase II-binding protein 1. (1526 aa) |
| | rfc3 | Replication factor C (Activator 1) 3. (356 aa) |
| | rnf168 | E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (474 aa) |
