STRINGSTRING
stat1a stat1a jak1 jak1 ptpn2b ptpn2b il10rb il10rb socs1a socs1a sumo1 sumo1 ifng1r ifng1r crfb4 crfb4 socs3b socs3b jak2b jak2b pias1b pias1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stat1aSignal transducer and activator of transcription. (749 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
ptpn2bTyrosine-protein phosphatase non-receptor type. (393 aa)
il10rbInterleukin 10 receptor, beta. (367 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
sumo1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as [...] (100 aa)
ifng1rInterferon gamma-related. (170 aa)
crfb4Cytokine receptor family member b4. (313 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
jak2bTyrosine-protein kinase. (1126 aa)
pias1bProtein inhibitor of-activated STAT, 1b. (659 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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