STRINGSTRING
syt9a syt9a arpc1a arpc1a amph amph cops2 cops2 slc18a3a slc18a3a necap1 necap1 stam2 stam2 m6pr m6pr nedd8 nedd8 dvl2 dvl2 cops3 cops3 arpc5b arpc5b cbl cbl cops7a cops7a UBB UBB ap2s1 ap2s1 rab5aa rab5aa vamp8 vamp8 rab5c rab5c tor1l3 tor1l3 cops8 cops8 hspa8b hspa8b agfg1a agfg1a ldlra ldlra dnm3a dnm3a fcho2 fcho2 tacr1a tacr1a actb1 actb1 pacsin1b pacsin1b ldlrap1b ldlrap1b cftr cftr pip5k1ca pip5k1ca igf2r igf2r itsn2a itsn2a apoba apoba oxt oxt cops4 cops4 clta clta necap2 necap2 actr2a actr2a tgfa tgfa tor1l1 tor1l1 vamp2 vamp2 ston2 ston2 cops5 cops5 arpc3 arpc3 syt11a syt11a LOC563561 LOC563561 sh3gl2a sh3gl2a ston1 ston1 snx18a snx18a eps15 eps15 arpc2 arpc2 hspa8 hspa8 actr2b actr2b wasla wasla hbegfa hbegfa trip10a trip10a arrb1 arrb1 cltcl1 cltcl1 tor1l2 tor1l2 gak gak vamp3 vamp3 arpc4 arpc4 itsn1 itsn1 sybl1 sybl1 reps1 reps1 cltcb cltcb il7r il7r sh3kbp1 sh3kbp1 si:ch73-7i4.3 si:ch73-7i4.3 pik3c2a pik3c2a stam stam hgs hgs syt2a syt2a actb2 actb2 grb2b grb2b avp avp dnm1a dnm1a agtr1b agtr1b ap2m1b ap2m1b ap2a1 ap2a1 rps27a rps27a epn2 epn2 adrb2a adrb2a lrp2a lrp2a ap2b1 ap2b1 slc2a8 slc2a8 snap91a snap91a gps1 gps1 chrm2a chrm2a dnm2a dnm2a hip1rb hip1rb btc btc wnt5a wnt5a ENSDARP00000137251 ENSDARP00000137251 tfr1a tfr1a epn1 epn1 ubc ubc scarb2a scarb2a ubb ubb sh3gl3a sh3gl3a syt1a syt1a cltb cltb LOC562049 LOC562049 epgn epgn ENSDARP00000146183 ENSDARP00000146183 scarb2b scarb2b avpr2ab avpr2ab dnajc6 dnajc6 grk3 grk3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
syt9aSynaptotagmin IXa. (547 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
amphAmphiphysin. (784 aa)
cops2COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. (443 aa)
slc18a3aProbable vesicular acetylcholine transporter-A; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (513 aa)
necap1NECAP endocytosis-associated 1. (261 aa)
stam2Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (509 aa)
m6prMannose-6-phosphate receptor (cation-dependent). (265 aa)
nedd8NEDD8 ubiquitin-like modifier. (89 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
cops3COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (424 aa)
arpc5bActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (913 aa)
cops7aCOP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
UBBSi:ch211-202a12.4. (459 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
rab5aaRAB5A, member RAS oncogene family, a. (216 aa)
vamp8Vesicle-associated membrane protein 8 (Endobrevin). (124 aa)
rab5cRAB5C, member RAS oncogene family. (221 aa)
tor1l3Torsin. (328 aa)
cops8COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (191 aa)
hspa8bSi:dkey-4p15.3; Belongs to the heat shock protein 70 family. (647 aa)
agfg1aArfGAP with FG repeats 1a. (556 aa)
ldlraLow density lipoprotein receptor a. (911 aa)
dnm3aDynamin 3a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (825 aa)
fcho2F-BAR domain only protein 2; May function in an early step of clathrin-mediated endocytosis. (848 aa)
tacr1aNeurokinin 1a receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
actb1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
pacsin1bProtein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neur [...] (445 aa)
ldlrap1bLow density lipoprotein receptor adaptor protein 1b. (304 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1485 aa)
pip5k1caPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (682 aa)
igf2rCation-independent mannose 6-phosphate receptor. (2459 aa)
itsn2aIntersectin 2a. (1665 aa)
apobaApolipoprotein Ba. (4418 aa)
oxtOxytocin; Belongs to the vasopressin/oxytocin family. (154 aa)
cops4COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (406 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (235 aa)
necap2NECAP endocytosis-associated 2. (260 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
tgfaTransforming growth factor, alpha. (191 aa)
tor1l1Torsin. (323 aa)
vamp2Vesicle-associated membrane protein 2. (110 aa)
ston2Stonin 2; Belongs to the Stoned B family. (854 aa)
cops5COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] (334 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
syt11aSynaptotagmin XIa. (451 aa)
LOC563561Bridging integrator 1a. (509 aa)
sh3gl2aSH3 domain-containing GRB2-like 2a, endophilin A1. (347 aa)
ston1General transcription factor IIA, 1-like; Belongs to the adaptor complexes medium subunit family. (634 aa)
snx18aSorting nexin. (567 aa)
eps15Epidermal growth factor receptor pathway substrate 15. (1039 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
hspa8Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
waslaWASP-like actin nucleation-promoting factor a. (502 aa)
hbegfaHeparin-binding EGF-like growth factor a. (230 aa)
trip10aCdc42-interacting protein 4 homolog; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Belongs to the FNBP1 family. (537 aa)
arrb1Arrestin, beta 1. (418 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1638 aa)
tor1l2Torsin. (355 aa)
gakCyclin G-associated kinase. (1325 aa)
vamp3Vesicle-associated membrane protein 3 (Cellubrevin). (102 aa)
arpc4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (193 aa)
itsn1Intersectin 1 (SH3 domain protein). (1722 aa)
sybl1Synaptobrevin-like 1; Belongs to the synaptobrevin family. (220 aa)
reps1RALBP1-associated Eps domain-containing 1. (790 aa)
cltcbClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
il7rInterleukin 7 receptor. (372 aa)
sh3kbp1SH3-domain kinase-binding protein 1. (669 aa)
si:ch73-7i4.3Si:ch73-7i4.3. (200 aa)
pik3c2aPhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1725 aa)
stamSignal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (516 aa)
hgsHepatocyte growth factor-regulated tyrosine kinase substrate. (757 aa)
syt2aSynaptotagmin IIa. (430 aa)
actb2Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
avpArginine vasopressin; Belongs to the vasopressin/oxytocin family. (151 aa)
dnm1aDynamin 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (852 aa)
agtr1bAngiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ap2m1bAP-2 complex subunit mu-B; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide- containing lipids (By similarity). (436 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
rps27aRibosomal protein S27a. (156 aa)
epn2Epsin 2. (590 aa)
adrb2aAdrenoceptor beta 2, surface a. (405 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
ap2b1AP complex subunit beta. (951 aa)
slc2a8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (498 aa)
snap91aSynaptosome-associated protein 91a. (913 aa)
gps1G protein pathway suppressor 1. (508 aa)
chrm2aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (495 aa)
dnm2aDynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa)
hip1rbHuntingtin-interacting protein 1-related b. (1065 aa)
btcBetacellulin, epidermal growth factor family member. (178 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
ENSDARP00000137251Si:ch73-215d9.1. (1037 aa)
tfr1aTransferrin receptor 1a. (770 aa)
epn1Epsin 1. (646 aa)
ubcUbiquitin C. (533 aa)
scarb2aScavenger receptor class B, member 2a; Belongs to the CD36 family. (531 aa)
ubbUbiquitin B. (610 aa)
sh3gl3aSH3-domain GRB2-like 3a. (358 aa)
syt1aSynaptotagmin Ia. (419 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
LOC562049Formin-binding protein 1b. (635 aa)
epgnEpithelial mitogen homolog (mouse). (148 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
scarb2bUncharacterized protein; Belongs to the CD36 family. (523 aa)
avpr2abArginine vasopressin receptor 2a, duplicate b. (441 aa)
dnajc6DnaJ (Hsp40) homolog, subfamily C, member 6. (913 aa)
grk3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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