STRINGSTRING
psmb9a psmb9a gata1a gata1a ldb1a ldb1a ccnh ccnh psma6a psma6a psma8 psma8 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 gata3 gata3 psmd11b psmd11b psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 mnat1 mnat1 UBB UBB psmc4 psmc4 psmb2 psmb2 psme2 psme2 cdk7 cdk7 psmc6 psmc6 psma2 psma2 psmc1b psmc1b psma4 psma4 tal1 tal1 psmd14 psmd14 psmb11b psmb11b yap1 yap1 psmb10 psmb10 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 psmd12 psmd12 psma3 psma3 tp73 tp73 runx1 runx1 lmo2 lmo2 psmb4 psmb4 psmd5 psmd5 abl1 abl1 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 rps27a rps27a itchb itchb psmf1 psmf1 psma1 psma1 lmo1 lmo1 tcf3b tcf3b psmd4a psmd4a ubc ubc ubb ubb cbfb cbfb psmd1 psmd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
gata1aGATA-binding protein 1a. (418 aa)
ldb1aLIM domain-binding protein 1-A; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (374 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
gata3Transcription factor GATA-3. (438 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
UBBSi:ch211-202a12.4. (459 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmb2Proteasome subunit beta. (199 aa)
psme2Proteasome activator subunit 2. (244 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (345 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
psmb10Proteasome subunit beta. (276 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
runx1Runt-related transcription factor. (451 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
abl1Tyrosine-protein kinase. (1081 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
rps27aRibosomal protein S27a. (156 aa)
itchbE3 ubiquitin-protein ligase. (842 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
lmo1Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. (175 aa)
tcf3bTranscription factor 3b. (652 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
cbfbCore-binding factor subunit beta. (201 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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