STRINGSTRING
psmb9a psmb9a psma6a psma6a psma8 psma8 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 psme1 psme1 psmb3 psmb3 xiap xiap psmd11b psmd11b akt2 akt2 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 UBB UBB frk frk psmc4 psmc4 otud3 otud3 trim35-20 trim35-20 trim35-34 trim35-34 psmb2 psmb2 trim35-28 trim35-28 csnk2a2b csnk2a2b psme2 psme2 psmc6 psmc6 psma2 psma2 mkrn1 mkrn1 trim35-40 trim35-40 trim35-30 trim35-30 psmc1b psmc1b usp13 usp13 psma4 psma4 trim35-1 trim35-1 trim35-3 trim35-3 trim35-29 trim35-29 F1QS63_DANRE F1QS63_DANRE trim35-7-2 trim35-7-2 trim35-39 trim35-39 trim35-14 trim35-14 wwp2 wwp2 psmd14 psmd14 psmb11b psmb11b psmb10 psmb10 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a prex2 prex2 psmc5 psmc5 csnk2b csnk2b B0S6Z7_DANRE B0S6Z7_DANRE ptena ptena psmd12 psmd12 psma3 psma3 akt3b akt3b zgc:194990 zgc:194990 F1R4U6_DANRE F1R4U6_DANRE F1R390_DANRE F1R390_DANRE zmp:0000001316 zmp:0000001316 psmb4 psmb4 trim35-9 trim35-9 stub1 stub1 rnf146 rnf146 psmd5 psmd5 trim35-22 trim35-22 F8W3P8_DANRE F8W3P8_DANRE U3JAQ6_DANRE U3JAQ6_DANRE psme4b psme4b U3JAZ2_DANRE U3JAZ2_DANRE si:rp71-45k5.4 si:rp71-45k5.4 trim35-4 trim35-4 trim35-13 trim35-13 rps27a rps27a ENSDARP00000130141 ENSDARP00000130141 trim35-19 trim35-19 csnk2a4 csnk2a4 nedd4a nedd4a psmf1 psmf1 trim35-24 trim35-24 ENSDARP00000133562 ENSDARP00000133562 trim35-23 trim35-23 psma1 psma1 ENSDARP00000134934 ENSDARP00000134934 zgc:136767 zgc:136767 trim35-21 trim35-21 trim35-12 trim35-12 LOC100536643 LOC100536643 psmd4a psmd4a ENSDARP00000139173 ENSDARP00000139173 ubc ubc trim35-27 trim35-27 ubb ubb psmd1 psmd1 trim35-33 trim35-33
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
xiapX-linked inhibitor of apoptosis. (405 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
UBBSi:ch211-202a12.4. (459 aa)
frkTyrosine-protein kinase. (512 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
otud3OTU deubiquitinase 3. (357 aa)
trim35-20Tripartite motif-containing 35-20. (453 aa)
trim35-34Tripartite motif-containing 35-34. (452 aa)
psmb2Proteasome subunit beta. (199 aa)
trim35-28Tripartite motif-containing 35-28. (477 aa)
csnk2a2bCasein kinase 2, alpha prime polypeptide b; Belongs to the protein kinase superfamily. (350 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
psma2Proteasome subunit alpha type. (234 aa)
mkrn1Probable E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (439 aa)
trim35-40Tripartite motif-containing 35-40. (468 aa)
trim35-30Tripartite motif-containing 35-30. (470 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
usp13Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (860 aa)
psma4Proteasome subunit alpha type. (261 aa)
trim35-1Tripartite motif-containing 35-1. (507 aa)
trim35-3Tripartite motif-containing 35-3. (454 aa)
trim35-29Tripartite motif-containing 35-29. (381 aa)
F1QS63_DANREUncharacterized protein. (463 aa)
trim35-7-2Tripartite motif-containing 35-7. (495 aa)
trim35-39Tripartite motif-containing 35-39. (447 aa)
trim35-14Tripartite motif-containing 35-14. (505 aa)
wwp2E3 ubiquitin-protein ligase. (867 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
psmb10Proteasome subunit beta. (276 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
prex2Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1600 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
csnk2bCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (215 aa)
B0S6Z7_DANRESi:dkey-18p12.4. (435 aa)
ptenaPhosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
zgc:194990Zgc:194990. (410 aa)
F1R4U6_DANRESi:ch211-14a17.10. (1303 aa)
F1R390_DANRESi:ch211-114c12.5. (458 aa)
zmp:0000001316Zmp:0000001316. (456 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
trim35-9Tripartite motif-containing 35-9. (385 aa)
stub1STIP1 homology and U-Box-containing protein 1. (287 aa)
rnf146E3 ubiquitin-protein ligase rnf146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair. (364 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
trim35-22Tripartite motif-containing 35-22. (451 aa)
F8W3P8_DANREUncharacterized protein. (452 aa)
U3JAQ6_DANRESi:ch211-120g10.1. (399 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
U3JAZ2_DANRESi:dkey-219e21.2. (443 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
trim35-4Tripartite motif-containing 35-4. (378 aa)
trim35-13Tripartite motif-containing 35-13. (469 aa)
rps27aRibosomal protein S27a. (156 aa)
ENSDARP00000130141Si:ch211-12p12.2. (453 aa)
trim35-19Tripartite motif-containing 35-19. (458 aa)
csnk2a4Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (389 aa)
nedd4aE3 ubiquitin-protein ligase. (787 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
trim35-24Tripartite motif-containing 35-24. (460 aa)
ENSDARP00000133562Si:ch73-364h19.2. (399 aa)
trim35-23Tripartite motif-containing 35-23. (451 aa)
psma1Proteasome subunit alpha type. (262 aa)
ENSDARP00000134934Si:dkey-219e21.4. (410 aa)
zgc:136767Zgc:136767. (481 aa)
trim35-21Tripartite motif-containing 35-21. (451 aa)
trim35-12Tripartite motif-containing 35-12. (510 aa)
LOC100536643Uncharacterized protein. (466 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ENSDARP00000139173Si:ch73-144l3.1. (384 aa)
ubcUbiquitin C. (533 aa)
trim35-27Tripartite motif-containing 35-27. (592 aa)
ubbUbiquitin B. (610 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
trim35-33Tripartite motif-containing 35-33. (459 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.