STRINGSTRING
psmb9a psmb9a hif1ab hif1ab wsb1 wsb1 psma6a psma6a psma8 psma8 psma5 psma5 fbxw2 fbxw2 psmd10 psmd10 cand1 cand1 psmc2 psmc2 psmb1 psmb1 ubxn7 ubxn7 vcp vcp klhl41b klhl41b asb8 asb8 cops2 cops2 psme1 psme1 psmb3 psmb3 commd2 commd2 skp1 skp1 wdr5 wdr5 asb6 asb6 psmd11b psmd11b nedd8 nedd8 cops3 cops3 senp8 senp8 asb7 asb7 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 nae1 nae1 lmo7a lmo7a dcaf11 dcaf11 dcaf13 dcaf13 cops7a cops7a asb1 asb1 UBB UBB ube2d1b ube2d1b dtl dtl kctd6b kctd6b psmc4 psmc4 ufd1l ufd1l cops8 cops8 pafah1b1b pafah1b1b btbd6b btbd6b psmb2 psmb2 pafah1b1a pafah1b1a fbxw4 fbxw4 zgc:161973 zgc:161973 hif1aa hif1aa wdr32 wdr32 psme2 psme2 ankrd9 ankrd9 commd7 commd7 psmc6 psmc6 fbxl3l fbxl3l asb12b asb12b rbx1 rbx1 klhl20 klhl20 dcaf7 dcaf7 psma2 psma2 fbxo32 fbxo32 spsb4b spsb4b zgc:114174 zgc:114174 rbbp5 rbbp5 nfe2l2a nfe2l2a ube2d2 ube2d2 psmc1b psmc1b cops4 cops4 klhl11 klhl11 eloca eloca commd3 commd3 fbxl14b fbxl14b psma4 psma4 asb5b asb5b fbxo22 fbxo22 fbxl8 fbxl8 rnf7 rnf7 spsb1 spsb1 cops5 cops5 uba3 uba3 fbxo30a fbxo30a socs6 socs6 F1QVS9_DANRE F1QVS9_DANRE mul1b mul1b dcaf5 dcaf5 klhl2 klhl2 klhl5 klhl5 fbxo31 fbxo31 fbxl7 fbxl7 fem1b fem1b socs5b socs5b psmd14 psmd14 commd9 commd9 psmb11b psmb11b ccdc22 ccdc22 psmb10 psmb10 ddb2 ddb2 ercc8 ercc8 commd1 commd1 skp2 skp2 fbxo9 fbxo9 ube2f ube2f vhl vhl psmd6 psmd6 kbtbd8 kbtbd8 uchl3 uchl3 psmd13 psmd13 zgc:173570 zgc:173570 zgc:153722 zgc:153722 psmb8a psmb8a nub1 nub1 socs3b socs3b psmc5 psmc5 wdtc1 wdtc1 fbxl20 fbxl20 cul5a cul5a cop1 cop1 dcaf6 dcaf6 fbxo21 fbxo21 asb13b asb13b fbxl5 fbxl5 psmd12 psmd12 klhl22 klhl22 psma3 psma3 hif1al2 hif1al2 cul1a cul1a commd4 commd4 fbxl15 fbxl15 bcl3 bcl3 fbxw10 fbxw10 dda1 dda1 spsb4a spsb4a commd5 commd5 dcaf8 dcaf8 dcun1d3 dcun1d3 dcun1d4 dcun1d4 socs2 socs2 klhl21 klhl21 F1R5J5_DANRE F1R5J5_DANRE kctd7 kctd7 commd6 commd6 spsb3a spsb3a rbb4l rbb4l asb2a.1 asb2a.1 psmb4 psmb4 tulp4a tulp4a zgc:114081 zgc:114081 zgc:100832 zgc:100832 wsb2 wsb2 fbxo10 fbxo10 dcaf17 dcaf17 fbxl4 fbxl4 si:rp71-1k13.6 si:rp71-1k13.6 psmd5 psmd5 fbxo41 fbxo41 A3QJV7_DANRE A3QJV7_DANRE lrrk2 lrrk2 keap1b keap1b cul4b cul4b fbxl16 fbxl16 psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 rps27a rps27a zbtb16b zbtb16b kbtbd7 kbtbd7 klhl25 klhl25 ddb1 ddb1 GAN GAN dcun1d1 dcun1d1 cul4a cul4a fbxo7 fbxo7 cul3b cul3b hif1al hif1al nploc4 nploc4 psmf1 psmf1 psma1 psma1 gps1 gps1 zgc:175088 zgc:175088 zgc:158376 zgc:158376 fbxl3a fbxl3a UBE2M UBE2M psmd4a psmd4a ubc ubc fem1c fem1c ubb ubb ankrd50l ankrd50l ccnf ccnf kbtbd13 kbtbd13 klhl3 klhl3 E9QHV0_DANRE E9QHV0_DANRE LOC555499 LOC555499 psmd1 psmd1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
wsb1WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (423 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
fbxw2F-box and WD repeat domain-containing 2. (455 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
cand1Cullin-associated and neddylation-dissociated 1. (1230 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
ubxn7UBX domain protein 7. (511 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
klhl41bKelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa)
asb8Ankyrin repeat and SOCS box-containing 8. (289 aa)
cops2COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. (443 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
commd2COMM domain-containing 2. (199 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
wdr5WD repeat domain 5. (334 aa)
asb6Ankyrin repeat and SOCS box-containing 6. (435 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
nedd8NEDD8 ubiquitin-like modifier. (89 aa)
cops3COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (424 aa)
senp8SUMO peptidase family member, NEDD8-specific. (212 aa)
asb7Ankyrin repeat and SOCS box-containing 7. (348 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
nae1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
lmo7aLIM domain 7a. (1826 aa)
dcaf11DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family. (541 aa)
dcaf13DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (445 aa)
cops7aCOP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
asb1Ankyrin repeat and SOCS box-containing 1. (335 aa)
UBBSi:ch211-202a12.4. (459 aa)
ube2d1bUbiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
dtlDenticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (647 aa)
kctd6bBTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. (237 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ufd1lUbiquitin recognition factor in ER-associated degradation 1. (308 aa)
cops8COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (191 aa)
pafah1b1bLissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa)
btbd6bBTB/POZ domain-containing protein 6-B; Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis (By similarity). (482 aa)
psmb2Proteasome subunit beta. (199 aa)
pafah1b1aLissencephaly-1 homolog A; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
fbxw4F-box and WD repeat domain-containing 4. (392 aa)
zgc:161973Zgc:161973 protein. (487 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
wdr32DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF10 family. (508 aa)
psme2Proteasome activator subunit 2. (244 aa)
ankrd9Ankyrin repeat domain 9. (287 aa)
commd7COMM domain-containing 7. (200 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
fbxl3lF-box and leucine-rich repeat protein 3,-like. (448 aa)
asb12bAnkyrin repeat and SOCS box-containing 12b. (308 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
klhl20Kelch-like family member 20. (591 aa)
dcaf7Ddb1 and cul4-associated factor 7. (342 aa)
psma2Proteasome subunit alpha type. (234 aa)
fbxo32F-box protein 32. (356 aa)
spsb4bSplA/ryanodine receptor domain and SOCS box-containing 4b. (281 aa)
zgc:114174Zgc:114174. (282 aa)
rbbp5Retinoblastoma-binding protein 5. (512 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
ube2d2Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
cops4COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (406 aa)
klhl11Kelch-like family member 11. (706 aa)
elocaElongin C paralog a; Belongs to the SKP1 family. (113 aa)
commd3COMM domain-containing 3. (192 aa)
fbxl14bF-box and leucine-rich repeat protein 14b. (400 aa)
psma4Proteasome subunit alpha type. (261 aa)
asb5bAnkyrin repeat and SOCS box-containing 5b. (328 aa)
fbxo22Novel protein with F-box domain. (385 aa)
fbxl8F-box and leucine-rich repeat protein 8. (367 aa)
rnf7Ring finger protein 7. (113 aa)
spsb1SplA/ryanodine receptor domain and SOCS box-containing 1. (273 aa)
cops5COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] (334 aa)
uba3NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). (462 aa)
fbxo30aF-box protein 30a. (740 aa)
socs6Suppressor of cytokine-signaling 6a. (519 aa)
F1QVS9_DANRESi:ch73-142c19.1. (471 aa)
mul1bMitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
dcaf5Ddb1 and cul4-associated factor 5. (789 aa)
klhl2Kelch-like family member 2. (590 aa)
klhl5Kelch-like family member 5. (769 aa)
fbxo31F-box protein 31. (542 aa)
fbxl7F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the FBXL7 family. (489 aa)
fem1bFem-1 homolog b. (638 aa)
socs5bSuppressor of cytokine signaling 5-like. (557 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
commd9Si:ch211-154e15.3 protein. (197 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
ccdc22Coiled-coil domain-containing protein 22; May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity). (639 aa)
psmb10Proteasome subunit beta. (276 aa)
ddb2DNA damage-binding protein 2; Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV- induced DNA damage. The ubiquitination of histones may facilitate their removal from th [...] (497 aa)
ercc8Excision repair cross-complementation group 8. (400 aa)
commd1Copper metabolism (Murr1) domain-containing 1. (189 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
fbxo9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. (421 aa)
ube2fNEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (185 aa)
vhlVon Hippel-Lindau tumor suppressor. (175 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
kbtbd8Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity). (601 aa)
uchl3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
zgc:173570Zgc:173570. (282 aa)
zgc:153722Zgc:153722. (281 aa)
psmb8aProteasome subunit beta. (271 aa)
nub1Negative regulator of ubiquitin-like proteins 1. (580 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
wdtc1WD and tetratricopeptide repeats 1. (674 aa)
fbxl20F-box and leucine-rich repeat protein 20. (436 aa)
cul5aCullin 5a; Belongs to the cullin family. (780 aa)
cop1Novel protein similar to vertebrate ring finger and WD repeat domain 2 (RFWD2, zgc:163067). (694 aa)
dcaf6Ddb1 and cul4-associated factor 6. (907 aa)
fbxo21F-box protein 21. (611 aa)
asb13bAnkyrin repeat and SOCS box-containing 13b. (294 aa)
fbxl5F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity). (679 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
klhl22Kelch-like family member 22. (625 aa)
psma3Proteasome subunit alpha type. (255 aa)
hif1al2Hypoxia-inducible factor 1 subunit alpha,-like 2. (663 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
commd4COMM domain-containing 4. (199 aa)
fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation. (310 aa)
bcl3BCL3 transcription coactivator. (619 aa)
fbxw10F-box and WD repeat domain-containing 10. (731 aa)
dda1DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins (By similarity); Belongs to the DDA1 family. (104 aa)
spsb4aSplA/ryanodine receptor domain and SOCS box-containing 4a. (277 aa)
commd5COMM domain-containing 5. (212 aa)
dcaf8DDB1 and CUL4-associated factor 8. (607 aa)
dcun1d3DCN1-like protein. (297 aa)
dcun1d4DCN1-like protein 4. (305 aa)
socs2Suppressor of cytokine signaling 2. (197 aa)
klhl21Kelch-like protein 21; Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity). (613 aa)
F1R5J5_DANRESi:dkey-147f3.8. (405 aa)
kctd7BTB/POZ domain-containing protein KCTD7. (339 aa)
commd6COMM domain-containing 6. (199 aa)
spsb3aSplA/ryanodine receptor domain and SOCS box-containing 3a. (358 aa)
rbb4lHistone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (426 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
tulp4aTUB-like protein 4a; Belongs to the TUB family. (1736 aa)
zgc:114081Zgc:114081. (211 aa)
zgc:100832Zgc:100832. (247 aa)
wsb2WD repeat and SOCS box-containing 2. (406 aa)
fbxo10F-box protein 10. (1015 aa)
dcaf17DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (526 aa)
fbxl4F-box and leucine-rich repeat protein 4. (616 aa)
si:rp71-1k13.6Si:rp71-1k13.6. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
fbxo41F-box protein 41. (805 aa)
A3QJV7_DANRESi:dkey-147f3.4. (182 aa)
lrrk2Leucine-rich repeat kinase 2. (2532 aa)
keap1bKelch-like ECH-associated protein 1B; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (593 aa)
cul4bCullin 4B; Belongs to the cullin family. (864 aa)
fbxl16F-box and leucine-rich repeat protein 16. (493 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
rps27aRibosomal protein S27a. (156 aa)
zbtb16bZinc finger and BTB domain-containing 16b. (659 aa)
kbtbd7Kelch repeat and BTB (POZ) domain-containing 7. (621 aa)
klhl25Ectodermal-neural cortex 2. (589 aa)
ddb1Damage-specific DNA-binding protein 1. (1142 aa)
GANGigaxonin. (525 aa)
dcun1d1DCN1-like protein. (282 aa)
cul4aCullin 4A; Belongs to the cullin family. (635 aa)
fbxo7F-box protein 7. (485 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
nploc4Nuclear protein localization 4 homolog (S. cerevisiae). (624 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
gps1G protein pathway suppressor 1. (508 aa)
zgc:175088Zgc:175088 protein. (177 aa)
zgc:158376Zgc:158376. (765 aa)
fbxl3aNovel protein similar to human and mouse F-box and leucine-rich repeat protein 3A (FBXL3A). (431 aa)
UBE2MSi:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ubcUbiquitin C. (533 aa)
fem1cProtein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. (438 aa)
ubbUbiquitin B. (610 aa)
ankrd50lAnkyrin repeat domain 50-like. (1441 aa)
ccnfCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily. (764 aa)
kbtbd13Kelch repeat and BTB (POZ) domain-containing 13. (473 aa)
klhl3Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. (637 aa)
E9QHV0_DANRESi:rp71-68n21.9. (686 aa)
LOC555499BTB (POZ) domain-containing 2b. (589 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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