STRINGSTRING
psmb9a psmb9a psma6a psma6a psma8 psma8 psma5 psma5 psmd10 psmd10 psmc2 psmc2 psmb1 psmb1 ubxn7 ubxn7 vcp vcp psme1 psme1 psmb3 psmb3 skp1 skp1 psmd11b psmd11b akt2 akt2 psmd8 psmd8 psmb6 psmb6 psmd9 psmd9 psmd3 psmd3 gsk3ba gsk3ba UBB UBB psmc4 psmc4 ufd1l ufd1l psmb2 psmb2 psme2 psme2 psmc6 psmc6 rbx1 rbx1 psma2 psma2 nfe2l2a nfe2l2a psmc1b psmc1b psma4 psma4 prdx1 prdx1 mul1b mul1b psmd14 psmd14 psmb11b psmb11b psmb10 psmb10 skp2 skp2 sesn2 sesn2 psmd6 psmd6 psmd13 psmd13 psmb8a psmb8a psmc5 psmc5 srxn1 srxn1 psmd12 psmd12 psma3 psma3 cul1a cul1a akt3b akt3b sqstm1 sqstm1 psmb4 psmb4 psmd5 psmd5 keap1b keap1b psme4b psme4b si:rp71-45k5.4 si:rp71-45k5.4 rps27a rps27a ep300b ep300b map1lc3b map1lc3b cul3b cul3b nploc4 nploc4 psmf1 psmf1 psma1 psma1 bach1b bach1b crebbpa crebbpa psmd4a psmd4a ubc ubc ubb ubb mafk mafk psmd1 psmd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb9aProteasome subunit beta. (218 aa)
psma6aProteasome subunit alpha type. (246 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma5Proteasome subunit alpha type. (241 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
psmc2Proteasome (Prosome, macropain) 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
psmb1Proteasome subunit beta. (237 aa)
ubxn7UBX domain protein 7. (511 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
psme1Proteasome activator subunit 1. (248 aa)
psmb3Proteasome subunit beta. (205 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
psmd11b26S proteasome non-ATPase regulatory subunit 11B; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity). (422 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (267 aa)
psmb6Proteasome subunit beta. (232 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
UBBSi:ch211-202a12.4. (459 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ufd1lUbiquitin recognition factor in ER-associated degradation 1. (308 aa)
psmb2Proteasome subunit beta. (199 aa)
psme2Proteasome activator subunit 2. (244 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
psma2Proteasome subunit alpha type. (234 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
psmc1bProteasome (Prosome, macropain) 26S subunit, ATPase, 1b; Belongs to the AAA ATPase family. (440 aa)
psma4Proteasome subunit alpha type. (261 aa)
prdx1Peroxiredoxin 1. (199 aa)
mul1bMitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmb11bProteasome 20S subunit beta 11b. (362 aa)
psmb10Proteasome subunit beta. (276 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
sesn2Sestrin 2. (444 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
psmd13Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (378 aa)
psmb8aProteasome subunit beta. (271 aa)
psmc5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
srxn1Sulfiredoxin. (140 aa)
psmd12Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (456 aa)
psma3Proteasome subunit alpha type. (255 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
sqstm1Sequestosome 1. (452 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (256 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (505 aa)
keap1bKelch-like ECH-associated protein 1B; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (593 aa)
psme4bProteasome activator complex subunit 4B; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved [...] (1845 aa)
si:rp71-45k5.4Proteasome subunit alpha type. (234 aa)
rps27aRibosomal protein S27a. (156 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
map1lc3bMicrotubule-associated protein 1 light chain 3 beta. (122 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
nploc4Nuclear protein localization 4 homolog (S. cerevisiae). (624 aa)
psmf1Proteasome inhibitor subunit 1. (272 aa)
psma1Proteasome subunit alpha type. (262 aa)
bach1bBTB and CNC homology 1, basic leucine zipper transcription factor 1 b. (632 aa)
crebbpaCREB-binding protein a. (2349 aa)
psmd4aProteasome 26S subunit, non-ATPase 4a. (372 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
mafkV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K. (157 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (993 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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