STRINGSTRING
mef2d mef2d pth4 pth4 cbfb cbfb bmpr1ab bmpr1ab bglapl bglapl bmpr1ba bmpr1ba lgr4 lgr4 igfbp3 igfbp3 junbb junbb bmpr1bb bmpr1bb nf1a nf1a men1 men1 nf1b nf1b cthrc1b cthrc1b gdf10a gdf10a ift80 ift80 adar adar cthrc1a cthrc1a lef1 lef1 nog2 nog2 junba junba bmpr2b bmpr2b wnt3 wnt3 ccn4b ccn4b gdf10b gdf10b pthlhb pthlhb wnt3a wnt3a tmem119b tmem119b jund jund bmp3 bmp3 nog1 nog1 ptch2 ptch2 tnn tnn ccn4a ccn4a nog3 nog3 bmp4 bmp4 snai2 snai2 pthlha pthlha ccn1 ccn1 bmpr1aa bmpr1aa smo smo igfbp5a igfbp5a bmpr2a bmpr2a sirt7 sirt7 tp53inp2-2 tp53inp2-2 bmp16 bmp16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mef2dMyocyte enhancer factor 2d. (529 aa)
pth4Parathyroid hormone 4; Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development. (121 aa)
cbfbCore-binding factor subunit beta. (201 aa)
bmpr1abReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
bglaplOsteocalcin; Binds strongly to apatite and calcium. (182 aa)
bmpr1baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
lgr4Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (971 aa)
igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
junbbJunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa)
bmpr1bbSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
nf1aNeurofibromin 1a. (2759 aa)
men1Multiple endocrine neoplasia I. (617 aa)
nf1bNeurofibromin 1b. (2759 aa)
cthrc1bCollagen triple helix repeat-containing 1b. (233 aa)
gdf10aGrowth differentiation factor 10a. (441 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
adarAdenosine deaminase RNA-specific. (1381 aa)
cthrc1aCollagen triple helix repeat-containing 1a. (232 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
junbaJunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ccn4bCellular communication network factor 4b. (356 aa)
gdf10bGrowth differentiation factor 10b. (422 aa)
pthlhbParathyroid hormone-related peptide 2. (162 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
tmem119bTransmembrane protein 119b. (294 aa)
jundJunD proto-oncogene, AP-1 transcription factor subunit. (283 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (452 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
tnnTenascin N. (932 aa)
ccn4aCellular communication network factor 4a. (360 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
pthlhaParathyroid hormone-like hormone a. (198 aa)
ccn1Cellular communication network factor 1. (369 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
igfbp5aInsulin-like growth factor-binding protein 5a. (268 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
sirt7Sirtuin 7. (405 aa)
tp53inp2-2Uncharacterized protein. (173 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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