STRINGSTRING
cdk5r1a cdk5r1a Q1LWT0_DANRE Q1LWT0_DANRE barhl1a barhl1a sh3rf1 sh3rf1 celsr1a celsr1a crkl crkl vangl2 vangl2 mdga2a mdga2a lhx1a lhx1a foxg1b foxg1b gas6 gas6 barhl1b barhl1b tubgcp2 tubgcp2 Reln Reln ENSDARP00000146009 ENSDARP00000146009 cntn2 cntn2 fat3a fat3a ndnf ndnf rapgef2 rapgef2 ENSDARP00000155277 ENSDARP00000155277 adgrl3.1 adgrl3.1 rapgef6 rapgef6 cdh2 cdh2 pex13 pex13 dnaaf4 dnaaf4 phox2bb phox2bb ENSDARP00000129086 ENSDARP00000129086 disc1 disc1 gpm6ab gpm6ab gata2b gata2b vegfab vegfab celsr2-2 celsr2-2 F1QYL7_DANRE F1QYL7_DANRE celsr3 celsr3 dclk1a dclk1a pomgnt2 pomgnt2 ccka ccka phox2ba phox2ba foxg1c foxg1c F1RD55_DANRE F1RD55_DANRE LOC568600 LOC568600 ENSDARP00000141230 ENSDARP00000141230 lrrc1 lrrc1 dab1a dab1a neo1a neo1a barhl2 barhl2 ENSDARP00000137251 ENSDARP00000137251 dcc dcc rest rest pcm1 pcm1 srfb srfb cckb cckb dclk1b dclk1b cdkl5 cdkl5 ADGRL3 ADGRL3 auts2a auts2a celsr1b celsr1b bbs4 bbs4 cdk5r2a cdk5r2a bbs1 bbs1 adgra3 adgra3 foxg1d foxg1d LOC100332721 LOC100332721 NAV1 NAV1 cdk5r2b cdk5r2b nav1b nav1b mdga1 mdga1 itga3b itga3b alkbh1 alkbh1 foxg1a foxg1a celsr2 celsr2 gata2a gata2a cdk5 cdk5 crk crk astn1 astn1 srfa srfa scrib scrib cdk5r1b cdk5r1b supt5h supt5h pex7 pex7 cep85l cep85l gpm6aa gpm6aa nrp2b nrp2b itga3a itga3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdk5r1aCyclin-dependent kinase 5 activator. (306 aa)
Q1LWT0_DANRECyclin-dependent kinase 5 activator. (317 aa)
barhl1aBarH-class homeodomain transcription factor 3. (299 aa)
sh3rf1E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway; Belongs to the SH3RF family. (880 aa)
celsr1aCadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family. (3044 aa)
crklV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
mdga2aMAM domain-containing glycosylphosphatidylinositol anchor 2a. (957 aa)
lhx1aLIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa)
foxg1bForkhead box G1b. (341 aa)
gas6Growth arrest-specific 6. (648 aa)
barhl1bBarH-like homeobox 1b. (323 aa)
tubgcp2Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (882 aa)
RelnReelin domain-containing protein. (259 aa)
ENSDARP00000146009CUB domain-containing protein. (101 aa)
cntn2Contactin 2. (1040 aa)
fat3aFAT atypical cadherin 3a. (4601 aa)
ndnfNeuron-derived neurotrophic factor. (585 aa)
rapgef2Rap guanine nucleotide exchange factor (GEF) 2. (1619 aa)
ENSDARP00000155277Uncharacterized protein. (241 aa)
adgrl3.1Adhesion G protein-coupled receptor L3.1; Belongs to the G-protein coupled receptor 2 family. (1540 aa)
rapgef6Rap guanine nucleotide exchange factor (GEF) 6. (1261 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
pex13Peroxisomal biogenesis factor 13. (416 aa)
dnaaf4Dynein axonemal assembly factor 4. (420 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
ENSDARP00000129086Neogenin 1b. (132 aa)
disc1DISC1 scaffold protein. (994 aa)
gpm6abGlycoprotein M6Ab. (292 aa)
gata2bGATA-binding protein 2b. (428 aa)
vegfabVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa)
celsr2-2Cadherin, EGF LAG seven-pass G-type receptor 2. (85 aa)
F1QYL7_DANRESi:ch211-193k19.1. (967 aa)
celsr3Cadherin, EGF LAG seven-pass G-type receptor 3. (2065 aa)
dclk1aDoublecortin-like kinase 1a. (770 aa)
pomgnt2Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] (585 aa)
cckaCholecystokinin a. (123 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
foxg1cForkhead box G1c. (379 aa)
F1RD55_DANRESi:ch211-213b8.4. (814 aa)
LOC568600FAT atypical cadherin 3b. (4362 aa)
ENSDARP00000141230MAM domain-containing protein. (104 aa)
lrrc1Leucine-rich repeat-containing 1. (438 aa)
dab1aDAB adaptor protein 1a. (586 aa)
neo1aNeogenin 1a. (1428 aa)
barhl2BarH-class homeodomain transcription factor. (364 aa)
ENSDARP00000137251Si:ch73-215d9.1. (1037 aa)
dccDCC netrin 1 receptor. (1200 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
pcm1Pericentriolar material 1. (2018 aa)
srfbSerum response factor b. (260 aa)
cckbCholecystokinin b. (117 aa)
dclk1bDoublecortin-like kinase 1b. (746 aa)
cdkl5Cyclin dependent kinase like 5 long. (1080 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1401 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
celsr1bCadherin EGF LAG seven-pass G-type receptor 1b; Belongs to the G-protein coupled receptor 2 family. (3006 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
cdk5r2aCyclin-dependent kinase 5 activator. (308 aa)
bbs1Bardet-Biedl syndrome 1. (588 aa)
adgra3Adhesion G protein-coupled receptor A3; Orphan receptor that acts as a critical modulator of planar cell polarity during gastrulation. Controls the localization of dishevelled. (727 aa)
foxg1dForkhead box G1d. (316 aa)
LOC100332721Neogenin 1b. (1413 aa)
NAV1Neuron navigator 1. (1485 aa)
cdk5r2bCyclin-dependent kinase 5 activator. (302 aa)
nav1bNeuron navigator 1b. (1790 aa)
mdga1MAM domain-containing glycosylphosphatidylinositol anchor 1. (808 aa)
itga3bIntegrin, alpha 3b; Belongs to the integrin alpha chain family. (1041 aa)
alkbh1AlkB homolog 1, histone H2A dioxygenase. (331 aa)
foxg1aForkhead box G1a. (420 aa)
celsr2Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2940 aa)
gata2aGATA-binding protein 2a. (456 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
crkV-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa)
astn1Astrotactin 1. (1305 aa)
srfaSerum response factor a. (539 aa)
scribProtein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa)
cdk5r1bCyclin-dependent kinase 5 activator. (304 aa)
supt5hTranscription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa)
pex7Peroxisomal biogenesis factor 7. (314 aa)
cep85lCentrosomal protein 85,-like. (781 aa)
gpm6aaGlycoprotein M6Aa. (278 aa)
nrp2bNeuropilin; Belongs to the neuropilin family. (920 aa)
itga3aIntegrin, alpha 3a; Belongs to the integrin alpha chain family. (1053 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.