STRINGSTRING
tgfbr2b tgfbr2b nes nes smad6a smad6a cxcl11.6 cxcl11.6 ccl38.1 ccl38.1 prl2 prl2 vegfbb vegfbb ccl19b ccl19b socs2 socs2 cxcl11.7 cxcl11.7 trim37 trim37 nars1 nars1 vegfd vegfd sh2b3 sh2b3 tgfb1b tgfb1b ifng1 ifng1 tgfb2 tgfb2 tyk2 tyk2 tlr5a tlr5a tlr5b tlr5b adam17b adam17b pgfb pgfb grem2a grem2a itcha itcha itchb itchb lifra lifra jak2a jak2a ccl35.1 ccl35.1 tgfbr3 tgfbr3 il6st il6st vegfaa vegfaa ecm1b ecm1b PDCL3 PDCL3 cxcl11.1 cxcl11.1 irak4 irak4 ngfa ngfa faslg faslg LOC100334604 LOC100334604 ecm1a ecm1a cxcl8a cxcl8a ccl20a.3 ccl20a.3 ccl39.7 ccl39.7 fadd fadd il1b il1b traf2b traf2b tnfsf13b tnfsf13b ENSDARP00000148508 ENSDARP00000148508 ENSDARP00000151894 ENSDARP00000151894 LOC101884175 LOC101884175 ccl25a ccl25a siva1 siva1 ccl38.6 ccl38.6 tgfb1a tgfb1a ifnphi2 ifnphi2 gh1 gh1 il11a il11a cxcl12a cxcl12a jak3 jak3 traf2a traf2a grem1a grem1a si:dkey-90m5.4 si:dkey-90m5.4 cnih4 cnih4 traf3 traf3 jak1 jak1 traf6 traf6 tnfa tnfa tgfb3 tgfb3 smad7 smad7 unm_sa808 unm_sa808 pibf1 pibf1 amh amh traf4a traf4a tnfb tnfb lft1 lft1 nradd nradd csf1b csf1b ccl19a.1 ccl19a.1 smad6b smad6b tnfsf12 tnfsf12 traf1 traf1 vegfc vegfc eda eda tgfb5 tgfb5 cd40lg cd40lg epoa epoa il12ba il12ba kitlga kitlga csf1a csf1a cdh5 cdh5 jak2b jak2b LOC100332300 LOC100332300 il34 il34 tnfsf13 tnfsf13 tnfsf11 tnfsf11 fem1b fem1b edaradd edaradd tgfbrap1 tgfbrap1 tgfbr2a tgfbr2a ntf3 ntf3 il11b il11b F1QAH4_DANRE F1QAH4_DANRE cxcl12b cxcl12b ebi3 ebi3 ngfb ngfb lft2 lft2 il17a/f1 il17a/f1 adam17a adam17a vegfba vegfba cxcl14 cxcl14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
nesNestin; Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development. (1265 aa)
smad6aMothers against decapentaplegic homolog. (456 aa)
cxcl11.6C-X-C motif chemokine 11-6; Ligand for cxcr3.2. Chemotactic for macrophages. (121 aa)
ccl38.1C-C motif chemokine. (103 aa)
prl2Prolactin 2. (237 aa)
vegfbbVascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (91 aa)
ccl19bChemokine (C-C motif) ligand 19b. (128 aa)
socs2Suppressor of cytokine signaling 2. (197 aa)
cxcl11.7C-X-C motif chemokine. (121 aa)
trim37Tripartite motif-containing 37. (957 aa)
nars1Asparaginyl-tRNA synthetase. (556 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
sh2b3SH2B adaptor protein 3. (596 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
ifng1Interferon gamma 1. (179 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
tyk2Tyrosine-protein kinase. (1165 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
adam17bADAM metallopeptidase domain 17b. (843 aa)
pgfbPlacental growth factor b; Belongs to the PDGF/VEGF growth factor family. (164 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
itchaE3 ubiquitin-protein ligase. (851 aa)
itchbE3 ubiquitin-protein ligase. (842 aa)
lifraProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (939 aa)
jak2aTyrosine-protein kinase. (1095 aa)
ccl35.1Chemokine (C-C motif) ligand 35, duplicate 1. (98 aa)
tgfbr3Transforming growth factor, beta receptor III. (848 aa)
il6stInterleukin 6 signal transducer. (866 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
ecm1bExtracellular matrix protein 1b. (499 aa)
PDCL3Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). (233 aa)
cxcl11.1C-X-C motif chemokine 11-1; Ligand for cxcr3.2. Chemotactic for macrophages. (94 aa)
irak4Interleukin-1 receptor-associated kinase 4. (447 aa)
ngfaNeurotrophin-7; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF; Belongs to the NGF-beta family. (233 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
LOC100334604SCY domain-containing protein. (121 aa)
ecm1aExtracellular matrix protein 1a. (173 aa)
cxcl8aInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
ccl20a.3C-C motif chemokine. (99 aa)
ccl39.7Chemokine (C-C motif) ligand 39, duplicate 7. (114 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
il1bInterleukin-1. (284 aa)
traf2bTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
tnfsf13bTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (268 aa)
ENSDARP00000148508ecTbetaR2 domain-containing protein. (382 aa)
ENSDARP00000151894Uncharacterized protein. (501 aa)
LOC101884175SCY domain-containing protein. (120 aa)
ccl25aChemokine (C-C motif) ligand 25a. (102 aa)
siva1SIVA1, apoptosis-inducing factor. (172 aa)
ccl38.6C-C motif chemokine. (166 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
ifnphi2Type I interferon 2. (181 aa)
gh1Growth hormone 1. (210 aa)
il11aInterleukin 11a. (219 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
jak3Tyrosine-protein kinase. (1103 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
grem1aGremlin. (177 aa)
si:dkey-90m5.4Si:dkey-90m5.4. (327 aa)
cnih4Cornichon family AMPA receptor auxiliary protein 4. (103 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
unm_sa808Un-named sa808. (281 aa)
pibf1Progesterone immunomodulatory-binding factor 1. (752 aa)
amhAnti-Mullerian hormone. (549 aa)
traf4aTNF receptor-associated factor. (470 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
nraddNeurotrophin receptor-associated death domain. (413 aa)
csf1bColony-stimulating factor 1b (macrophage). (284 aa)
ccl19a.1C-C motif chemokine. (119 aa)
smad6bMothers against decapentaplegic homolog. (486 aa)
tnfsf12Tumor necrosis factor superfamily member 12; Belongs to the tumor necrosis factor family. (236 aa)
traf1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
cd40lgCD40 ligand; Belongs to the tumor necrosis factor family. (260 aa)
epoaErythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (183 aa)
il12baInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (350 aa)
kitlgaKit ligand a. (272 aa)
csf1aColony-stimulating factor 1a (macrophage). (526 aa)
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
jak2bTyrosine-protein kinase. (1126 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
il34Si:ch211-239j19.3 protein. (213 aa)
tnfsf13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (199 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
fem1bFem-1 homolog b. (638 aa)
edaraddEDAR-associated death domain. (219 aa)
tgfbrap1Transforming growth factor-beta receptor-associated protein 1 homolog; Plays a role in the TGF-beta signaling pathway. Belongs to the TRAP1 family. (863 aa)
tgfbr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (243 aa)
il11bInterleukin 11b. (192 aa)
F1QAH4_DANRETGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa)
cxcl12bChemokine (C-X-C motif) ligand 12B (Stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (97 aa)
ebi3Epstein-Barr virus-induced 3. (302 aa)
ngfbNerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity). (194 aa)
lft2Left-right determination factor. (362 aa)
il17a/f1Interleukin 17a/f1. (153 aa)
adam17aADAM metallopeptidase domain 17a. (842 aa)
vegfbaVascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (246 aa)
cxcl14Chemokine (C-X-C motif) ligand 14. (100 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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