STRINGSTRING
ankrd31 ankrd31 sirt7 sirt7 bag6l bag6l MAJIN MAJIN ENSDARP00000142615 ENSDARP00000142615 ccne2 ccne2 ENSDARP00000139474 ENSDARP00000139474 CCNB1IP1 CCNB1IP1 syce2 syce2 tex15 tex15 spata22 spata22 msh5 msh5 ccdc36 ccdc36 msh4 msh4 rnf212b rnf212b mlh3 mlh3 terb1 terb1 LOC108192159 LOC108192159 mei4 mei4 mlh1 mlh1 zgc:194246 zgc:194246 rnf212 rnf212 moto moto tex11 tex11 B3DFT5_DANRE B3DFT5_DANRE rec8b rec8b meiob meiob dmc1 dmc1 fancd2 fancd2 hormad1 hormad1 terb2 terb2 psmc3ip psmc3ip trip13 trip13 prdm9 prdm9 spo11 spo11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ankrd31Ankyrin repeat domain 31. (261 aa)
sirt7Sirtuin 7. (405 aa)
bag6lLarge proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1216 aa)
MAJINSi:dkey-23i12.11. (196 aa)
ENSDARP00000142615Si:dkey-40g16.5. (123 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (392 aa)
ENSDARP00000139474Si:ch211-241j8.2. (453 aa)
CCNB1IP1Si:ch211-212k18.11. (251 aa)
syce2Synaptonemal complex central element protein 2. (187 aa)
tex15Testis-expressed 15. (259 aa)
spata22Spermatogenesis-associated 22. (322 aa)
msh5MutS homolog 5. (789 aa)
ccdc36Coiled-coil domain-containing 36. (382 aa)
msh4MutS homolog 4. (931 aa)
rnf212bSi:ch211-10e2.1. (236 aa)
mlh3MutL homolog 3 (E. coli). (1171 aa)
terb1Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] (814 aa)
LOC108192159REC8 meiotic recombination protein a. (460 aa)
mei4Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Belongs to the MEI4L family. (363 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (725 aa)
zgc:194246Zgc:194246. (97 aa)
rnf212Ring finger protein 212. (285 aa)
motoMinamoto. (851 aa)
tex11Testis-expressed 11. (913 aa)
B3DFT5_DANRESi:ch211-199g17.1. (206 aa)
rec8bREC8 meiotic recombination protein b. (564 aa)
meiobMethionine sulfoxide reductase B1b. (466 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
fancd2FA complementation group D2. (1445 aa)
hormad1HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. (356 aa)
terb2Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] (212 aa)
psmc3ipPSMC3-interacting protein. (213 aa)
trip13Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (424 aa)
prdm9Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] (853 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (383 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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