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ENSDARP00000155118 | Uncharacterized protein. (350 aa) | ||||
ptchd1 | Patched domain-containing protein 1. (887 aa) | ||||
tmem17 | Transmembrane protein 17B; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (191 aa) | ||||
wdr19 | WD repeat domain 19. (1372 aa) | ||||
ENSDARP00000148508 | ecTbetaR2 domain-containing protein. (382 aa) | ||||
cfap410 | Cilia and flagella-associated protein 410. (364 aa) | ||||
nsdhl | NAD(P)-dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa) | ||||
rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) | ||||
iqub | IQ motif and ubiquitin domain-containing. (750 aa) | ||||
ssna1 | Sjogren syndrome nuclear autoantigen 1. (115 aa) | ||||
sufu | Suppressor of fused homolog. (485 aa) | ||||
talpid3 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa) | ||||
ift27 | Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa) | ||||
ulk3 | Unc-51-like kinase 3. (407 aa) | ||||
gli1 | GLI family zinc finger 1. (1404 aa) | ||||
wdpcp | WD repeat-containing planar cell polarity effector. (707 aa) | ||||
shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
hhat | Hedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (508 aa) | ||||
ift80 | Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa) | ||||
ptchd4 | Patched domain-containing protein 1. (897 aa) | ||||
sept2 | Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (401 aa) | ||||
ro60 | Ro60, Y RNA-binding protein. (534 aa) | ||||
boc | BOC cell adhesion-associated, oncogene-regulated. (1032 aa) | ||||
arl13b | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa) | ||||
zgc:158640 | Zgc:158640. (134 aa) | ||||
cdon | Cell adhesion molecule-related/down-regulated by oncogenes. (1125 aa) | ||||
stk36 | Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa) | ||||
bbs7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa) | ||||
mks1 | MKS transition zone complex subunit 1. (559 aa) | ||||
tgfbr2a | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa) | ||||
ihhb | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa) | ||||
ihha | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa) | ||||
F1QAH4_DANRE | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
ift52 | Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa) | ||||
disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) | ||||
disp2 | Protein dispatched homolog 2; Belongs to the dispatched family. (1476 aa) | ||||
zgc:77752 | Zgc:77752. (626 aa) | ||||
tmem231 | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (309 aa) | ||||
gli3 | GLI family zinc finger 3. (1553 aa) | ||||
shhb | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa) | ||||
her15.1 | Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa) | ||||
her15.2 | Zgc:136520 protein. (149 aa) | ||||
scube2 | Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa) | ||||
dhh | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa) | ||||
ttc21b | Tetratricopeptide repeat domain 21B. (1321 aa) | ||||
tgfbr2b | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa) | ||||
stil | SCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). (1263 aa) | ||||
ttc26 | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. (557 aa) | ||||
zgc:63587 | Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (276 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
rb1 | Retinoblastoma 1. (903 aa) | ||||
gli2b | GLI family zinc finger 2b. (1225 aa) | ||||
b9d1 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (201 aa) | ||||
smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) | ||||
zgc:112294 | Transmembrane protein 17A; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (222 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
fkbp16 | Peptidylprolyl isomerase. (430 aa) | ||||
fkbp8 | Peptidylprolyl isomerase. (406 aa) |