STRINGSTRING
ENSDARP00000155118 ENSDARP00000155118 ptchd1 ptchd1 tmem17 tmem17 wdr19 wdr19 ENSDARP00000148508 ENSDARP00000148508 cfap410 cfap410 nsdhl nsdhl rest rest iqub iqub ssna1 ssna1 sufu sufu talpid3 talpid3 ift27 ift27 ulk3 ulk3 gli1 gli1 wdpcp wdpcp shha shha ENSDARP00000125042 ENSDARP00000125042 hhat hhat ift80 ift80 ptchd4 ptchd4 sept2 sept2 ro60 ro60 boc boc arl13b arl13b zgc:158640 zgc:158640 cdon cdon stk36 stk36 bbs7 bbs7 mks1 mks1 tgfbr2a tgfbr2a ihhb ihhb ihha ihha F1QAH4_DANRE F1QAH4_DANRE ptch2 ptch2 ift52 ift52 disp1 disp1 disp2 disp2 zgc:77752 zgc:77752 tmem231 tmem231 gli3 gli3 shhb shhb her15.1 her15.1 her15.2 her15.2 scube2 scube2 dhh dhh ttc21b ttc21b tgfbr2b tgfbr2b stil stil ttc26 ttc26 zgc:63587 zgc:63587 ptch1 ptch1 rb1 rb1 gli2b gli2b b9d1 b9d1 smo smo zgc:112294 zgc:112294 gli2a gli2a fkbp16 fkbp16 fkbp8 fkbp8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSDARP00000155118Uncharacterized protein. (350 aa)
ptchd1Patched domain-containing protein 1. (887 aa)
tmem17Transmembrane protein 17B; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (191 aa)
wdr19WD repeat domain 19. (1372 aa)
ENSDARP00000148508ecTbetaR2 domain-containing protein. (382 aa)
cfap410Cilia and flagella-associated protein 410. (364 aa)
nsdhlNAD(P)-dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
iqubIQ motif and ubiquitin domain-containing. (750 aa)
ssna1Sjogren syndrome nuclear autoantigen 1. (115 aa)
sufuSuppressor of fused homolog. (485 aa)
talpid3Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa)
ift27Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa)
ulk3Unc-51-like kinase 3. (407 aa)
gli1GLI family zinc finger 1. (1404 aa)
wdpcpWD repeat-containing planar cell polarity effector. (707 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
hhatHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (508 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
ptchd4Patched domain-containing protein 1. (897 aa)
sept2Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (401 aa)
ro60Ro60, Y RNA-binding protein. (534 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
zgc:158640Zgc:158640. (134 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
stk36Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa)
bbs7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
mks1MKS transition zone complex subunit 1. (559 aa)
tgfbr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
F1QAH4_DANRETGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ift52Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
disp2Protein dispatched homolog 2; Belongs to the dispatched family. (1476 aa)
zgc:77752Zgc:77752. (626 aa)
tmem231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (309 aa)
gli3GLI family zinc finger 3. (1553 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
her15.1Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa)
her15.2Zgc:136520 protein. (149 aa)
scube2Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. (1010 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
ttc21bTetratricopeptide repeat domain 21B. (1321 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
stilSCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). (1263 aa)
ttc26Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. (557 aa)
zgc:63587Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (276 aa)
ptch1Protein patched homolog 1. (1475 aa)
rb1Retinoblastoma 1. (903 aa)
gli2bGLI family zinc finger 2b. (1225 aa)
b9d1B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (201 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
zgc:112294Transmembrane protein 17A; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (222 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
fkbp16Peptidylprolyl isomerase. (430 aa)
fkbp8Peptidylprolyl isomerase. (406 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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