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klhl41b klhl41b gdf5 gdf5 myl1 myl1 myod1 myod1 myog myog gpcpd1 gpcpd1 klf5a klf5a klhl40b klhl40b smo smo rbfox1l rbfox1l ankrd33ab ankrd33ab rb1 rb1 chrna1 chrna1 mylpfb mylpfb unc45b unc45b lamc1 lamc1 atf3 atf3 six1b six1b myo9ab myo9ab myo9aa myo9aa myf6 myf6 myoz2a myoz2a FOXN2 FOXN2 tcf21 tcf21 klhl40a klhl40a six1a six1a meox2a meox2a myoz1a myoz1a vgll2a vgll2a disp1 disp1 foxn2b foxn2b spg11 spg11 mylpfa mylpfa gdf6a gdf6a smyd2a smyd2a cdk5 cdk5 ankrd33ba ankrd33ba bves bves popdc3 popdc3 mtmr12 mtmr12 myo9b myo9b ripor2 ripor2 meox2b meox2b lmod3 lmod3 klhl41a klhl41a mstnb mstnb popdc2 popdc2 ankrd1a ankrd1a myf5 myf5 svilb svilb phox2ba phox2ba mef2d mef2d hlx1 hlx1 lamc3 lamc3 ankrd33aa ankrd33aa asb2a.1 asb2a.1 ripor3 ripor3 selenon selenon nf1b nf1b taz taz ankrd33bb ankrd33bb klf5b klf5b myoz2b myoz2b elnb elnb kel kel shha shha klf5l klf5l arpp21 arpp21 asb2a.2 asb2a.2 rbm24b rbm24b nf1a nf1a ep300b ep300b phox2bb phox2bb smyd1b smyd1b LOC108190739 LOC108190739 dner dner stac3 stac3 rbm24a rbm24a bin3 bin3 adss1 adss1 r3hdm2 r3hdm2 homer1b homer1b r3hdm1 r3hdm1 ep300a ep300a qkia qkia hoxc10a hoxc10a qkib qkib svila svila bcl9 bcl9 ENSDARP00000153449 ENSDARP00000153449 nphs1 nphs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
klhl41bKelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa)
gdf5Growth differentiation factor 5. (474 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
gpcpd1Glycerophosphocholine phosphodiesterase 1. (666 aa)
klf5aProgesterone immunomodulatory-binding factor 1. (429 aa)
klhl40bKelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (618 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
rbfox1lRNA binding protein fox-1 homolog 1-like; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. (382 aa)
ankrd33abAnkyrin repeat domain 33Ab. (462 aa)
rb1Retinoblastoma 1. (903 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
mylpfbMyosin light chain, phosphorylatable, fast skeletal muscle b. (170 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
atf3Activating transcription factor 3. (202 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
myo9abUnconventional myosin-IXAb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance. (2286 aa)
myo9aaUnconventional myosin-IXAa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance. (2522 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
myoz2aMyozenin 2a. (264 aa)
FOXN2Forkhead box N2. (300 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
klhl40aKelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (612 aa)
six1aHomeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. (283 aa)
meox2aMesenchyme homeobox 2a. (302 aa)
myoz1aZgc:77785 protein. (319 aa)
vgll2aVestigial-like family member 2a. (296 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
foxn2bForkhead box N2b. (388 aa)
spg11SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
smyd2aN-lysine methyltransferase SMYD2-A; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (435 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ankrd33baAnkyrin repeat domain 33ba. (510 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
popdc3Popeye domain-containing 3. (294 aa)
mtmr12Myotubularin-related protein 12; Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location. By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis. In skeletal muscle cells, does not regulate mtm1 subcellular localization. (736 aa)
myo9bMyosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
meox2bMesenchyme homeobox 2b. (289 aa)
lmod3Leiomodin-3; Essential for the organization of sarcomeric thin filaments in skeletal muscle; Belongs to the tropomodulin family. (670 aa)
klhl41aKelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)
ankrd1aAnkyrin repeat domain 1a (cardiac muscle). (317 aa)
myf5Myogenic factor. (237 aa)
svilbSupervillin b. (179 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
hlx1H2.0-like homeo box 1 (Drosophila). (356 aa)
lamc3Laminin, gamma 3. (1643 aa)
ankrd33aaAnkyrin repeat domain 33Aa. (428 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
ripor3RIPOR family member 3; Belongs to the RIPOR family. (997 aa)
selenonSelenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa)
nf1bNeurofibromin 1b. (2759 aa)
tazTafazzin family protein; Belongs to the taffazin family. (262 aa)
ankrd33bbAnkyrin repeat domain 33Bb. (448 aa)
klf5bKruppel-like factor 5b. (344 aa)
myoz2bMyozenin 2b. (226 aa)
elnbElastin b. (2041 aa)
kelKell metallo-endopeptidase (Kell blood group). (759 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
klf5lKruppel-like factor 5 like. (401 aa)
arpp21cAMP-regulated phosphoprotein, 21. (688 aa)
asb2a.2Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa)
rbm24bRNA-binding motif protein 24b. (245 aa)
nf1aNeurofibromin 1a. (2759 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
smyd1bSET and MYND domain-containing 1b. (486 aa)
LOC108190739Myozenin-2-like. (122 aa)
dnerDelta/notch-like EGF repeat-containing. (744 aa)
stac3SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...] (334 aa)
rbm24aRNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa)
bin3Bridging integrator 3. (253 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa)
r3hdm2R3H domain-containing 2. (923 aa)
homer1bHomer scaffold protein 1b. (398 aa)
r3hdm1R3H domain-containing 1. (815 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
qkiaProtein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa)
hoxc10aHomeobox C10a. (337 aa)
qkibProtein quaking-B. (347 aa)
svilaSupervillin a. (1763 aa)
bcl9BCL9 transcription coactivator. (1573 aa)
ENSDARP00000153449HP domain-containing protein. (82 aa)
nphs1NPHS1 adhesion molecule, nephrin. (1287 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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