STRINGSTRING
tmie tmie p2rx2 p2rx2 cldn7b cldn7b eya2 eya2 marveld2a marveld2a myo3b myo3b optc optc uts1 uts1 adgrv1 adgrv1 mkks mkks slc26a5 slc26a5 lhfpl3 lhfpl3 hpn hpn tmc2b tmc2b hexb hexb hexa hexa grapa grapa fer1l6 fer1l6 myo6b myo6b cx30.3 cx30.3 zgc:158291 zgc:158291 tectb tectb tmc2a tmc2a lhfpl5b lhfpl5b cfap57 cfap57 tecta tecta kcnq1.1 kcnq1.1 ddit3 ddit3 ush2a ush2a ripor2 ripor2 wfs1a wfs1a TMC1 TMC1 lrig1 lrig1 tspeara tspeara get1 get1 spns2 spns2 whrna whrna ush1c ush1c epyc epyc tspearb tspearb tmem132e tmem132e tmtc4 tmtc4 scarb2c scarb2c myo6a myo6a myo3a myo3a ptprq ptprq eya1 eya1 otofa otofa ripor3 ripor3 whrnb whrnb loxhd1b loxhd1b espnlb espnlb grapb grapb marveld2b marveld2b loxhd1a loxhd1a pgap1 pgap1 espn espn grxcr1b grxcr1b otofb otofb pjvk pjvk pou4f3 pou4f3 wfs1b wfs1b crym crym fbxo11b fbxo11b espnla espnla eya4 eya4 clrn3 clrn3 tprn tprn fbxo11a fbxo11a fzd4 fzd4 scarb2a scarb2a pdzd7a pdzd7a clrn1 clrn1 kcnq1.2 kcnq1.2 ENSDARP00000142279 ENSDARP00000142279 otos otos grxcr1a grxcr1a tomt tomt cdkn2d cdkn2d strc1 strc1 lhfpl4a lhfpl4a lhfpl5a lhfpl5a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tmieTransmembrane inner ear. (231 aa)
p2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
cldn7bClaudin-7-B; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. (215 aa)
eya2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (475 aa)
marveld2aMARVEL domain-containing 2a. (545 aa)
myo3bMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
optcOpticin. (322 aa)
uts1Urotensin 1. (138 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
mkksMcKusick-Kaufman syndrome. (563 aa)
slc26a5Solute carrier family 26, member 5. (739 aa)
lhfpl3LHFPL tetraspan subfamily member 3 protein. (216 aa)
hpnNovel protein similar to H.sapiens HPN, hepsin (Transmembrane protease, serine 1) (HPN); Belongs to the peptidase S1 family. (425 aa)
tmc2bTransmembrane channel-like protein 2-B; Belongs to the TMC family. (892 aa)
hexbBeta-hexosaminidase. (541 aa)
hexaBeta-hexosaminidase. (532 aa)
grapaGRB2-related adaptor protein a. (214 aa)
fer1l6Fer-1-like family member 6. (1790 aa)
myo6bMyosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa)
cx30.3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (267 aa)
zgc:158291POU domain protein. (343 aa)
tectbZgc:101843 protein. (336 aa)
tmc2aTransmembrane channel-like protein 2-A; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells. (916 aa)
lhfpl5bLHFPL tetraspan subfamily member 5b. (221 aa)
cfap57Cilia and flagella-associated protein 57. (1024 aa)
tectaTectorin alpha. (2201 aa)
kcnq1.1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
ddit3DNA-damage-inducible transcript 3. (242 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
wfs1aWolfram syndrome 1a (wolframin). (814 aa)
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
lrig1Leucine-rich repeats and immunoglobulin-like domains 1. (1022 aa)
tspearaThrombospondin-type laminin G domain and EAR repeats a. (676 aa)
get1Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa)
spns2Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (105 aa)
whrnaWhirlin a. (939 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
epycEpiphycan. (712 aa)
tspearbThrombospondin-type laminin G domain and EAR repeats b. (666 aa)
tmem132eTransmembrane protein 132E; Required for normal inner ear hair cell function and hearing. (1073 aa)
tmtc4Transmembrane O-mannosyltransferase targeting cadherins 4. (739 aa)
scarb2cScavenger receptor class B, member 2c; Belongs to the CD36 family. (274 aa)
myo6aMyosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
ptprqProtein tyrosine phosphatase receptor type Q. (2301 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
otofaOtoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. (1992 aa)
ripor3RIPOR family member 3; Belongs to the RIPOR family. (997 aa)
whrnbWhirlin b. (946 aa)
loxhd1bLipoxygenase homology domains 1b. (2215 aa)
espnlbEspin-like b. (1004 aa)
grapbGRB2-related adaptor protein b. (214 aa)
marveld2bMARVEL domain-containing 2b. (572 aa)
loxhd1aLipoxygenase homology domains 1a. (2122 aa)
pgap1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (952 aa)
espnEspin. (873 aa)
grxcr1bGlutaredoxin and cysteine-rich domain-containing 1 b. (148 aa)
otofbOtoferlin b. (1773 aa)
pjvkPejvakin. (361 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
wfs1bWolfram syndrome 1b (wolframin). (895 aa)
crymCrystallin, mu. (283 aa)
fbxo11bF-box protein 11a. (879 aa)
espnlaEspin-like a. (925 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (638 aa)
clrn3Clarin 3. (230 aa)
tprnTaperin. (758 aa)
fbxo11aF-box protein 11a. (844 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
scarb2aScavenger receptor class B, member 2a; Belongs to the CD36 family. (531 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
clrn1Clrn1 protein. (232 aa)
kcnq1.2Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (531 aa)
ENSDARP00000142279Transmembrane channel-like protein. (536 aa)
otosOtospiralin. (90 aa)
grxcr1aGlutaredoxin and cysteine-rich domain-containing 1 a. (295 aa)
tomtTransmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. (259 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (168 aa)
strc1Stereocilin 1. (2032 aa)
lhfpl4aLHFPL tetraspan subfamily member 4a. (215 aa)
lhfpl5aLHFPL tetraspan subfamily member 5a. (226 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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