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qkib | Protein quaking-B. (347 aa) | ||||
rfx4 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family. (735 aa) | ||||
kif7 | Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa) | ||||
serpine2 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (395 aa) | ||||
ttc21b | Tetratricopeptide repeat domain 21B. (1321 aa) | ||||
mosmob | Modulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. (167 aa) | ||||
fbxl17 | F-box and leucine-rich repeat protein 17. (348 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
gpr161 | G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa) | ||||
mgrn1b | Mahogunin, ring finger 1b. (549 aa) | ||||
prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) | ||||
mks1 | MKS transition zone complex subunit 1. (559 aa) | ||||
hhip | Hedgehog-interacting protein. (693 aa) | ||||
stk36 | Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa) | ||||
ttc23 | Tetratricopeptide repeat domain 23. (463 aa) | ||||
dlg5a | Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa) | ||||
dlg5b.1 | Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1888 aa) | ||||
intu | Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity); Belongs to the inturned family. (926 aa) | ||||
fam92a1 | Protein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Plays a role in ciliogenesis (By similarity). (295 aa) | ||||
glis2a | GLIS family zinc finger 2a. (446 aa) | ||||
fuz | Fuzzy planar cell polarity protein. (420 aa) | ||||
tctn1 | Tectonic family member 1. (534 aa) | ||||
dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) | ||||
armc9 | LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis. (544 aa) | ||||
prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) | ||||
rpgrip1l | RPGRIP1-like. (1256 aa) | ||||
mosmoa | Uncharacterized protein. (167 aa) | ||||
ift140 | Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa) | ||||
tubd1 | Tubulin, delta 1; Belongs to the tubulin family. (446 aa) | ||||
wdr11 | WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. (1239 aa) | ||||
E7FAM4_DANRE | Si:ch211-237c6.4; Belongs to the G-protein coupled receptor 1 family. (524 aa) | ||||
mgrn1a | Probable E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Acts also as a negative regulator of hedgehog signaling. (529 aa) | ||||
glis2b | GLIS family zinc finger 2b. (489 aa) | ||||
ulk3 | Unc-51-like kinase 3. (407 aa) | ||||
prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) | ||||
gas8 | Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper slow muscle development and positively regulates ciliary smoothened (SMO)-dependent Hedgehog ( [...] (475 aa) | ||||
scube1 | Signal peptide, CUB domain, EGF-like 1. (1067 aa) | ||||
rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) | ||||
qkia | Protein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa) | ||||
uchl5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) | ||||
gpc3 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By sim [...] (590 aa) | ||||
scube3 | Signal peptide, CUB domain, EGF-like 3. (1002 aa) | ||||
ENSDARP00000153433 | annotation not available (144 aa) | ||||
rb1 | Retinoblastoma 1. (903 aa) | ||||
ift81 | Intraflagellar transport 81 homolog. (675 aa) | ||||
smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) | ||||
txndc15 | Interferon regulatory factor 1b. (286 aa) | ||||
prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) |