STRINGSTRING
gpc3 gpc3 scube3 scube3 qkib qkib ENSDARP00000153433 ENSDARP00000153433 ulk3 ulk3 prkacab prkacab txndc15 txndc15 smo smo ift81 ift81 rb1 rb1 prkacba prkacba rfx4 rfx4 kif7 kif7 serpine2 serpine2 ttc21b ttc21b mosmob mosmob fbxl17 fbxl17 ptch2 ptch2 gpr161 gpr161 mgrn1b mgrn1b prkacbb prkacbb mks1 mks1 hhip hhip stk36 stk36 ttc23 ttc23 dlg5a dlg5a dlg5b.1 dlg5b.1 intu intu fam92a1 fam92a1 glis2a glis2a fuz fuz tctn1 tctn1 dzip1 dzip1 armc9 armc9 rpgrip1l rpgrip1l mosmoa mosmoa ift140 ift140 tubd1 tubd1 wdr11 wdr11 E7FAM4_DANRE E7FAM4_DANRE glis2b glis2b mgrn1a mgrn1a prkacaa prkacaa gas8 gas8 scube1 scube1 rest rest qkia qkia uchl5 uchl5
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpc3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By sim [...] (590 aa)
scube3Signal peptide, CUB domain, EGF-like 3. (1002 aa)
qkibProtein quaking-B. (347 aa)
ENSDARP00000153433annotation not available (144 aa)
ulk3Unc-51-like kinase 3. (407 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
txndc15Interferon regulatory factor 1b. (286 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
ift81Intraflagellar transport 81 homolog. (675 aa)
rb1Retinoblastoma 1. (903 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
rfx4Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family. (735 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
serpine2Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (395 aa)
ttc21bTetratricopeptide repeat domain 21B. (1321 aa)
mosmobModulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. (167 aa)
fbxl17F-box and leucine-rich repeat protein 17. (348 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa)
mgrn1bMahogunin, ring finger 1b. (549 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
mks1MKS transition zone complex subunit 1. (559 aa)
hhipHedgehog-interacting protein. (693 aa)
stk36Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa)
ttc23Tetratricopeptide repeat domain 23. (463 aa)
dlg5aDiscs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa)
dlg5b.1Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1888 aa)
intuProtein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity); Belongs to the inturned family. (926 aa)
fam92a1Protein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Plays a role in ciliogenesis (By similarity). (295 aa)
glis2aGLIS family zinc finger 2a. (446 aa)
fuzFuzzy planar cell polarity protein. (420 aa)
tctn1Tectonic family member 1. (534 aa)
dzip1Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa)
armc9LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis. (544 aa)
rpgrip1lRPGRIP1-like. (1256 aa)
mosmoaUncharacterized protein. (167 aa)
ift140Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa)
tubd1Tubulin, delta 1; Belongs to the tubulin family. (446 aa)
wdr11WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. (1239 aa)
E7FAM4_DANRESi:ch211-237c6.4; Belongs to the G-protein coupled receptor 1 family. (524 aa)
glis2bGLIS family zinc finger 2b. (489 aa)
mgrn1aProbable E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Acts also as a negative regulator of hedgehog signaling. (529 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
gas8Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper slow muscle development and positively regulates ciliary smoothened (SMO)-dependent Hedgehog ( [...] (475 aa)
scube1Signal peptide, CUB domain, EGF-like 1. (1067 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
qkiaProtein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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