STRINGSTRING
agtr1a agtr1a fgfr1a fgfr1a ccn1 ccn1 plaa plaa fgfr1b fgfr1b phb phb s1pr4 s1pr4 htr2aa htr2aa LOC569566 LOC569566 pth1a pth1a agtr1b agtr1b htr2ab htr2ab vegfaa vegfaa lpar1 lpar1 htr2b htr2b arl1 arl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
agtr1aAngiotensin II receptor, type 1a; Belongs to the G-protein coupled receptor 1 family. (358 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
ccn1Cellular communication network factor 1. (369 aa)
plaaPhospholipase A2-activating protein. (798 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
phbProhibitin. (271 aa)
s1pr4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (389 aa)
htr2aa5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (402 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
pth1aParathyroid hormone 1a. (102 aa)
agtr1bAngiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
htr2ab5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b. (458 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)
arl1ADP-ribosylation factor-like 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]